ABSTRACT
Some indices of nonspecific reactivity: the number of cyclic immunological complexes, titer of antibodies, activity of alkaline and acid phosphatases, alanine aminotranspherase, mitochondrial liver H(+)-ATPase, content of glutathione ceruloplasmin transferrin are stated to change in the model of food anaphylaxis in 37 guinea pigs, 26 rats and 12 rabbits orally sensitized with hen egg protein and they are estimated prior to and after the allergy development.
Subject(s)
Egg Proteins/immunology , Food Hypersensitivity/immunology , Immunization/methods , Administration, Oral , Anaphylaxis/blood , Anaphylaxis/etiology , Anaphylaxis/immunology , Animals , Antibodies/blood , Antigen-Antibody Complex/blood , Chickens , Dose-Response Relationship, Immunologic , Egg Proteins/administration & dosage , Food Hypersensitivity/blood , Food Hypersensitivity/etiology , Guinea Pigs , Immunity, Innate/immunology , Rabbits , Rats , Time FactorsABSTRACT
Circulating immune complexes (CIC) in the serum and anterior eye chamber were simultaneously measured by 4% polyethylene glycol in 23 ophthalmologic patients. The patients with noncomplicated cataracts were found to have elevated serum levels of CIC (175 +/- 8.1 opt. units, p less than 0.001), whereas the patients with glaucoma, diabetic angioretinopathy, and complicated myopia had even higher CIC levels in the serum (247 +/- 7.1 opt. units, p less than 0.001) together with the increased CIC levels in the anterior eye chamber fluid (29.43 +/- 0.88 opt. units, p less than 0.001), which fact is indicative of the augmentation of the autoimmune component it the progress of the dystrophic changes in the eye tissues.