Carcinoma ex pleomorphic adenoma of the submandibular gland with distant metastases.

A case of metastatic carcinoma ex pleomorphic adenoma (PA) of the submandibular gland is reported. While reports of local recurrence of this cancer are numerous, few cases of distant metastases have been reported. We report a case of a 52-year-old male patient with a history of PA diagnosed ten years previous. The patient presented reporting that the mass had increased size and pain during the previous six months. Needle biopsy results of this mass were compatible with a poorly differentiated carcinoma of the salivary ducts. Radical surgery with wide right neck dissection was performed with curative intent. Three years post-surgery liver and bony metastases were detected. In conclusion, the potential for malignant transformation of PA demands close follow-up of younger patients.

[Hypertrophic osteoarthropathy: a rare manifestation of an amygdalar tumour]. / Osteoartropatía hipertrófica: una rara manifestación de un tumor amigdalar.

A case of hypertrophic osteoarthropathy in association with malignant tonsil tumour is reported. It involved a patient in whom the bone disorder was detected 10 months prior to the clinical manifestation of the tumour. Hypertrophic pneumic osteoarthropathy is a clinical and radiological syndrome characterized by proliferation of periosteum in long bones with digital clubbing. In over 90 % of the cases, it has been associated with an intra-thoracic tumour and more rarely secondary to a malignant haemopathy or ENT cancer, particularly of the rhinopharynx. As far as we know, the association with carcinoma of the tonsils has not previously been described.

Osteoartropatía hipertrófica: una rara manifestación de un tumor amigdalar / Hypertrophic osteoarthropathy: a rare manifestation of an amygdalar tumour

Presentamos un caso de osteoartropatía hipertrófica como manifestación acompañante de un tumor maligno amigdalar, en un paciente al que se detectó la anomalía ósea 10 meses antes de la presentación clínica del tumor. La osteoartropatía hipertrófica pneúmica es un síndrome clínico-radiológico caracterizado por proliferación del periostio de huesos tubulares con hipocratismo digital. En más del 90 % de los casos se ha relacionado con un tumor intratorácico, más raramente secundario a hemopatía maligna o cáncer otorrinolaríngeo, sobre todo de rinofaringe. La asociación con tumor amigdalar, en nuestro conocimiento, no se ha descrito

A case of hypertrophic osteoarthropathy in association with malignant tonsil tumour is reported. It involved a patient in whom the bone disorder was detected 10 months prior to the clinical manifestation of the tumour. Hypertrophic pneumic osteoarthropathy is a clinical and radiological syndrome characterized by proliferation of periosteum in long bones with digital clubbing. In over 90 % of the cases, it has been associated with an intra-thoracic tumour and more rarely secondary to a malignant haemopathy or ENT cancer, particularly of the rhinopharynx. As far as we know, the association with carcinoma of the tonsils has not previously been described

A correlation between age and Actinomyces in the adenotonsillar tissue of children.

The purpose of this study was to investigate the presence of actinomyces in adenotonsillar disease, recurrent infections, or tonsillar hypertrophy in children. The study included 64 patients, ranging in age from 2 to 16 years, who had elective adenotonsillar surgery to treat either adenotonsillar hypertrophy (36 children) or recurrent adenotonsillitis (28 children). Adenotonsillar Actinomyces was present in 30 children (48%). No statistical significance was found between Actinomyces and recurrent adenotonsillitis or adenotonsillar hypertrophy. However, there was a statistically significant relationship identified between the presence of actinomycosis and age, with a greater occurrence of actinomycosis in children between 5 and 16 years old.

Submucosal glands and goblet cells in maxillary sinus surgery: an experimental study in rabbits.

HYPOTHESIS: After sinus surgery poor ciliary activity and disorders in mucus production can lead to an increase in postoperative complications. PURPOSE OF THIS STUDY: To evaluate the changes in the ultrastructure of submucosal glands (SG) and goblet cells (GC) after partial or wide surgical removal of maxillary sinus mucosa (MSM). METHODS: Twenty New Zealand White rabbits were divided in two groups of 10 animals. In group A, the mucosa of the right maxillary sinus (MS) was removed. In contrast, in group B only a strip the mucosa around the ostium was removed. After three months the sinus were opened and the mucosa studied by light-, and scanning- and transmision electron microscopy. RESULTS: After three months in group A all right MS were infected with purulent secretions, and the density of SG with a mean value of 10.4 per mm, standard deviation (SD) 3.36 and GC 81.81 per mm (SD: 3.82). However, in group B the SG were 52.3 per mm (SD: 4.5) and GC 4.45 per mm (SD: 1.23). These results were statistically significant (p < 0.001). Histopathological findings showed in group A, after three months, SG with a fewer number of microvilli in the glandular lumen.

[Ciliary changes with abscence of dynein arms in Kartagener's syndrome]. / Alteración ciliar con ausencia de los brazos de dineina en el síndrome de Kartagener.

A 33 years-old female with a diagnosis of Kartagener's syndrome was studied. She had a clinical history of chronic sinusitis with nasal obstruction and rhinorrea, and a chronic cough with mucopurulent sputum. A paranasal sinus CT showed hypertrophyc mucosa. A thoracic CT showed a situs inversus and chronic bronchitis with bronchiectasis. The saccharin test lasted 55 minutes. The electron microscopy study showed in a a cross-sectional axoneme a total absence of the outer and inner arm of the 9th outer doublet in over a 100 cilias studied. No others ultrastructure anormalities were observed.

Alteración ciliar con ausencia de los brazos de dineina en el síndrome de Kartagener / Ciliary changes with abscence of dynein arms in Kartagener's syndrome

Presentamos el caso de una mujer de 33 años diagnosticada de síndrome de Kartagener. La paciente refiere una historia de rinorrea y obstrucción nasal de larga evolución sugestiva de sinusitis crónica y de tos acompañada de expectoración mucopurulenta. En TC de senos paranasales se aprecia una mucosa sinusal hipertrófica. En TC de tórax de observa un situs inversus y bronquiectasias. El tiempo del test de la sacarina fue de 55 minutos. El estudio ciliar con microscopío electrónico mostró una ausencia completa de los dos brazos del doblete número nueve en más de 100 cilios estudiados. No se observaron otras alteraciones ultraestructurales (AU)

A 33 years-old female with a diagnosis of Kartagener's syndrome was studied. She had a clinical history of chronic sinusitis with nasal obstruction and rhinorrea, and a chronic cough with mucopurulent sputum. A paranasal sinus CT showed hypertrophyc mucosa. A thoracic CT showed a situs inversus and chronic bronchitis with bronchiectasis. The saccharin test lasted 55 minutes. The electron microscopy study showed in a a cross-sectional axoneme a total absence of the outer and inner arm of the 9th outer doublet in over a 100 cilias studied. No others ultrastructure anormalities were observed (AU)

[A histochemical study of the glandular system of the human epiglottis. The clinical implications]. / Estudio histoquímico del sistema glandular de la epiglotis humana. Implicaciones clínicas.

The paper deals about classical histologic and histochemical study for mucinoid substances through 7 laryngeal pieces coming from clinic autopsies. The gland units occurring in the two lower thirds of the epiglottis were formed by a great number of serous acini and mucinous tubuli, which secretion is acid and neutral mucous substances, as sialomucins, serving as lubricant and protective means. This glandular system convey through the epiglottic perforans holes, without break, the pre-epiglottic and epiglottic spaces, with the clinical repercussion that suggest the chance of encroachment for incipient epiglottic cancer to pre-epiglottic room.

[Histochemical study with lectins submucous glands of the hamster's tongue]. / Estudio histoquímico mediante lectinas de las glándulas submucosas linguales. Estudio en el hámster.

A histochemical study, with lectins, in oropharyngeal cavity of 5 Syrian golden Hamsters (Mesocricetus auratus) was performed in order to know the tongue submucous glands characteristics. Results showed a strong reactivity to HPA lectin for secretions of submucous glands of the Hamster's tongue and a slight reactivity to N-WGA and to WGA lectins.

[Study by S-100 polyclonal antibodies of Langerhans cells in vocal cord polyps]. / Estudio mediante anticuerpos policlonales S-100 de las células de Langerhans en los pólipos de cuerda vocal.

In 10 patients (5 smokers) with benign laryngeal polyp of a single vocal cord, a biopsy was performed. Five normal control specimens were obtained from the larynx of recently deceased patients who underwent postmortem study. Langerhans cells were counted in specimens of histologically normal and pathological vocal cord mucosa after identification with S-100 polyclonal antibody. Langerhans cells were 11.5-fold more common in the epithelium of vocal cord polyps than in the mucosa of normal vocal cords.

[Differences between epiglottis and cricoid cartilages. Histochemical study with lectins in hamsters]. / Diferencias entre el cartílago de epiglotis y el de cricoides. Estudio histoquímico con lectinas en el hámster.

An histochemistry study with lectins was performed in the epiglottis and cricoid cartilages of 4 Syrian golden hamsters (Mesocricetus auratus). The results show that there are differences in glycoconjugates between both cartilages. In the epiglottic matrix there was no reactivity to HPA, PNA and DBA lectins. However the cricoid cartilage showed no reactivity to SBA. Neither of cartilage matrixes were reactive to LTA or Con-A.

[The rat's vomeronasal organ. Histochemical study with lectins]. / El órgano vomeronasal de la rata. Estudio histoquímico mediante lectinas.

A histochemistry study by means of lectins of vomeronasal organ or Jacobson's organ was performed in 5 Wistar rats. Vomeronasal organ is localized at the antero-inferior level of the septum and present two kinds of epithelium, an olfactory one and other respiratory, on the medial and on the lateral part, respectively. Olfactory epithelium shows a great reactivity to WGA lectin, moderate to PNA and weck to Con-A and SBA. In the respiratory epithelium the reactivity is moderate to DBA, PNa, SBA and WGA lectins for goblet cells, instead the periciliary sheat of mucus is reactive to all lectins but DBA and LTA.

[Olfactory epithelium of the rat. Lectin-mediated histochemical studies]. / El epitelio olfatorio de la rata. Estudio histoquímico mediante lectinas.

A histochemical study with lectins of the olfactory epithelium of 5 Wistar rats was performed. This neuro-epithelium cover the postero-superior part of the nasal cavity and the medial part of the vomeronasal organon. There are numerous Bowman's glands in the olfactory epithelium, besides the sensory cells. These glandulae dye as well with PAS.AB, the same as the mucosal layer over the epithelium, which show its composition on sialo-sulfomucines. The mucous layer over the olfactory epithelium shows a great reactivity to WGA, moderate to PNA and Con-A and weak to SBA. On the other hand Bowman's glands show an intense reactivity to PNA and moderate to WGA, VEA-I and to Con-A.

[Histochemical differences between submucous glands and Goblet cells of the supraglottis. A study on hamsters]. / Diferencias histoquímicas entre las glándulas submucosas y las células caliciformes de la supraglotis. Estudio en el hámster.

In order to know the differences between the submucosal glands and the goblet cells of the supraglottic mucosa, a lectin histochemistry study was performed in 4 larynx of hamster (Mesocricetus auratus). The results show a strong reactivity to HPA and N-WGA lectins in the submucosal glands. Also reactivity to N-PNA and UEA-1 was present in the submucous glands but not in the goblet cells.

[Subepithelial glands in the hamster's larynx]. / Estudio de las glándulas subepiteliales en la laringe del hamster.

We have performed, with light microscope, a study about the distribution and morphology of the subepithelial glands of the hamster's larynx. The results are: at the base of the tongue the great deal of the glands are mucous, at the epiglottic base seromucous and at the subglottic space (at the level of cricoid cartilage) serous.

[Histological study of the rat's nasal sinus cavity. Its use in investigation]. / Estudio histológico de la cavidad nasosinusal de la rata. Su utilización en investigación.

An histologic study was performed by light microscopy of the rat nasal cavity. A neuroepithelial lining is found in the backside of the cavity and the medial portion of vomeronasal organ. A respiratory seudostratified epithel with a great deal of submucous glandulae cover the remainder of the cavity.

[Mast cells in the nasal mucosa of patients with nasal polyps. A histological study with lectins]. / Los mastocitos en la mucosa nasal de pacientes con poliposis nasal. Estudio histoquímico con lectinas.

Histochemical studies done with lectins are helpful for differentiate between several carbohydrates and glycoproteins of cell structures. Mast cells predominate in the nasal polyps mucosa of these patients. Cytoplasmic granules of mastocyts reacted to all lectins employed but LTA.