[Radio-adaptive response in repair-defective cells from patients with homocystinuria]. / Radioadaptivnyi otvet v reparatsionno-defektnykh kletkakh bol'nykh gomotsistinuriei.

Two lines of fibroblasts isolated by skin biopsy from patients with homocystinuria were characterized as repair-defective cells. Preirradiation of these cells at low doses (0.1 Gy) and irradiation at high doses demonstrated their decreased ability to form radioadaptive response, in comparison with normal cells. Radioadaptive response did not differ from that of normal cells after chemical treatment with 4NQO and NG used as damaging agents. The method for detection of DNA breaks by means of hydroxyapatite column chromatography of cell lysates and the method of determining sister chromatid exchanges (SCE) were used.

[The adaptive response in the lymphocytes of children from an area with an elevated background of ionizing radiation]. / Adaptivnyi otvet v limfotsitakh detei iz zony s povyshennym fonom ioniziruiushchei radiatsii.

The ability to form the adaptive response in lymphocytes of 23 children, exposed to small radiation doses as the result of Chernobyl accident was studied by hydroxylapatite chromatography of cell lysates. No correlation was found between the ability to form adaptive response and received radiation dose.

[The formation of an adaptive response in children exposed to the effect of low doses of radiation as a result of the accident at the Chernobyl Atomic Electric Power Station]. / Formirovanie adaptivnogo otveta u detei, podvergshikhsia vliianiiu malykh doz radiatsii v rezul'tate avarii na ChAES.

The ability of lymphocytes to form an adaptive response in cells of the children which were exposed to small radiation doses during the Chernobyl accident was studied by hydroxyapatite chromatography of cell lysates. Ten children living in the area with high radiation level (Bryansk region) and seventeen children living in the area with natural radiation level (Bryansk region too) were examined. No difference in cell ability to form adaptive response was found in both children group.

[Absence of adaptive DNA repair in xeroderma pigmentosum cells]. / Otsutstvie adaptivnoi reparatsii DNK v kletkakh pigmentnoi kserodermy.

Adaptive repair is the restoration of chemically induced DNA breaks in human fibroblasts previously gamma-irradiated at low doses. The adaptive repair in xeroderma pigmentosum (XP) cells was compared to that in normal human fibroblasts. The obtained results suggest that the repair is inducible and error-free. Adaptive repair was not found in XP cells in experiments with 4-NQO. This is correlated with the presence of an excision repair defect in XP.