[Isoenzymes of lactate dehydrogenase, alkaline phosphatase, creatine kinase. Possible use as tumor markers]. / Isoenzimi della lattato deidrogenasi, fosfatasi alcalina, creatin-chinasi. Possibilità di impiego come markers tumorali.

The electrophoresis of serum isoenzymes in cancer pathology at different stages has enabled us to recognise for LDH4 and LDH5, characteristics of sensitivity in all stages, with positivity greater than 60% in the advanced and multiply metastasized stages or with interference from other pathologies; to reveal portions pathologically heavy like FAST (46%); to reveal atypical bands (BB and MIT), as well as the values for normal or really low enzymatic activity. Through the elevated sensitivity and the high percentage of positivity, the isoenzymes LDH4 and LDH5 can be considered tumour markers and superior in validity to the conventional markers.

[Preliminary evaluation of the effect of ibopamine on the secretion of prolactin]. / Valutazione preliminare dell'effetto della ibopamina sulla secrezione di prolattina.

Ibopamine, diisobutyric ester of N-methyl dopamine, is an orally active dopaminergic agonist. The prolactin-lowering activity of Ibopamine was studied in 8 subjects with normal prolactine levels given the drug in a single dose of 100 mg. Prolactin levels measured by radioimmuno assay were evaluated before and within 2, 4 and 8 h of administration. Afterwards prolactin levels were evaluated after 4 and 8 days of treatment with Ibopamine administered at a dose of 50 mg three times daily. Ibopamine was shown to decrease prolactin to a statistically significant extent at the 2nd h after administration. At the 4th h prolactin returned to baseline values. After 4 and 8 treatment days prolactin levels did not differ significantly from baseline values. These results provide further evidence for the dopaminergic activity of Ibopamine and suggest a more through investigation in hyperprolactinemic subjects.

[Effects of dopamine, noradrenaline and isoproterenol on pulmonary circulation in anesthetized dogs]. / Effetti della dopamina, della noradrenalina e dell'isoproterenolo sul circolo polmonare di cani anestetizzati.

Experiments were performed on 19 anaesthetized open-chest dog instrumented with polyethylene catheters inserted: into the aorta, in pulmonary artery and in left atrium and with an electromagnetic flow-transducer placed around the ascending aorta in order to record : systemic arterial and pulmonary pressures, mean left auricular pressure and phasic aortic flow. Heart rate, stroke volume, total systemic and pulmonary resistance, cardiac work were moreover calculated. Each dog was given intravenously by slow infusione : Dopamine (micrograms 5--10--20/kg/min/ 5 min), Isoproterenol (microgram 0.125--0.25--0.5/kg/min/5 min) and Norepinephrine (microgram 0.25--0.5--1 /kg/min/5 min). Results obtained on systemic hemodynamics agree with those reported by many other investigators. On pulmonary circulation : Isoproterenol, at the tested doses, elicited vasodilator effects, Norepinephrine increased total pulmonary resistance but not pulmonary vascular resistance, while Dopamine did not modify or slightly reduced vascular pulmonary tone.