ABSTRACT
The authors have repeatedly examined the functional capacity of suprarenal cortex in patients on long-term dialysis by means of ACTH stimulation test. Out of 148 examinations, normal reaction was found in 111 cases, partially insufficient in 16 cases, and fully insufficient in 21 cases. Primary suprarenal insufficiency is considered for the reason of insufficient production of cortisol which develops due to enforced changes of regulatory mechanism in glucocorticoids production as a reaction on repeated long-term losses of cortisol through semipermeable membrane. According to the authors, the mentioned facts are of great significance since they may result in changes which influence the survival of patients on long-term dialysis in a negative way.
Subject(s)
Adrenal Cortex/physiopathology , Kidney Failure, Chronic/therapy , Renal Dialysis , 11-Hydroxycorticosteroids/blood , Adrenal Cortex Function Tests , Adrenocorticotropic Hormone , Female , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/physiopathology , MaleSubject(s)
Angiography , Biopsy, Needle/adverse effects , Kidney/pathology , Liver/pathology , Ultrasonography , Adult , Female , Humans , Male , Middle Aged , Renal Artery/diagnostic imagingSubject(s)
Carbon Tetrachloride Poisoning/diagnosis , Adult , Carbon Tetrachloride Poisoning/therapy , Humans , Male , Middle AgedSubject(s)
Acute Kidney Injury/therapy , Renal Dialysis/methods , Adolescent , Adult , Czechoslovakia , Female , Humans , Male , Middle Aged , Prognosis , Retrospective StudiesSubject(s)
Acute Kidney Injury/diagnostic imaging , Angiography/methods , Kidney Failure, Chronic/diagnostic imaging , Ultrasonography , Acute Kidney Injury/diagnosis , Acute Kidney Injury/pathology , Biopsy/methods , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/pathology , Radiographic Magnification/methodsSubject(s)
Hypertension, Renal/diagnosis , Radioisotope Renography , Adolescent , Adult , Aged , Humans , Hypertension, Renal/diagnostic imaging , Middle Aged , UrographyABSTRACT
Authors studied serotonin (5-hydroxytryptamin) in blood in patients with severe renal failure. Changes of serotonin in platelets and plasma in renal failure possibly play a part in clotting disorders of uremia. The authors found increased levels of serotonin in the patients, who suffered from acute and chronic renal failure. 15 patients were dialysed in regular dialysis treatment. Serotonin increased in blood after each dialysis. Platelets remained unchanged during hemodialysis. The authors discuss these new findings and correlate the above mentioned changes with electrolytes and some other laboratory findings.
