ABSTRACT
The distribution of allele and genotype frequencies of genes of xenobiotic detoxication (CYP2E1--PstI, RsaI, DraI; ADH, ALDH, NAT2, GSTP1, GSTM1, GSTT1) was examined in 147 patients with reflux-esophagitis (RE) and 50 conditionally healthy children 12-18 years. The frequency of AA genotype of GSTP1 gene and A allele was significantly higher in patients with RE as compared with healthy children (χ2 = 4.93; P = 0.03 and χ2 = 5.94; P = 0.01 respectively).
Subject(s)
Esophagitis, Peptic/genetics , Glutathione S-Transferase pi/genetics , Polymorphism, Genetic , Adolescent , Aldehyde Dehydrogenase/genetics , Alleles , Arylamine N-Acetyltransferase/genetics , Case-Control Studies , Child , Cytochrome P-450 CYP2E1/genetics , Esophagitis, Peptic/pathology , Female , Gene Expression , Gene Frequency , Genotype , Glutathione Transferase/genetics , Humans , Male , Neurophysins/genetics , Protein Precursors/genetics , Vasopressins/geneticsABSTRACT
Several parameters of chlorin e6 and its derivative chlorin e6 ethylenediamide have been investigated as these compound are potential sensitizers for photodynamic therapy. A study carried out to compare the cellular uptake of the pigments indicates that chlorin e6 ethylenediamide possesses an enhanced affinity for tumour cells and cellular membranes. Comparison of the uptake in induced sarcoma shows that chlorin e6 ethylenediamide is a much better tumour localizer than chlorin e6. The efficiency of phototherapy with chlorin e6 ethylenediamide is higher than that with chlorin e6. These data show the influence of the substitution of the carboxyl groups in chlorin e6 by ester and amide groups on the photosensitizing properties of the pigments.