ABSTRACT
Viruses are associated with several human diseases that infect a large number of individuals, hence directly affecting global health and economy. Owing to the lack of efficient vaccines, antiviral therapy and emerging resistance strains, many viruses are considered as a potential threat to public health. Therefore, researches have been developed to identify new drug candidates for future treatments. Among them, antiviral research based on natural molecules is a promising approach. Phospholipases A2 (PLA2s) isolated from snake venom have shown significant antiviral activity against some viruses such as Dengue virus, Human Immunodeficiency virus, Hepatitis C virus and Yellow fever virus, and have emerged as an attractive alternative strategy for the development of novel antiviral therapy. Thus, this review provides an overview of remarkable findings involving PLA2s from snake venom that possess antiviral activity, and discusses the mechanisms of action mediated by PLA2s against different stages of virus replication cycle. Additionally, molecular docking simulations were performed by interacting between phospholipids from Dengue virus envelope and PLA2s from Bothrops asper snake venom. Studies on snake venom PLA2s highlight the potential use of these proteins for the development of broad-spectrum antiviral drugs.
Subject(s)
Antiviral Agents/pharmacology , Phospholipases A2/pharmacology , Snake Venoms/enzymology , Snakes/metabolism , Animals , Dengue Virus/drug effects , Drug Resistance, Viral/drug effects , HIV/drug effects , Hepacivirus/drug effects , Molecular Docking Simulation , Reptilian Proteins/pharmacology , Yellow fever virus/drug effectsABSTRACT
This paper presents an analog technique for the demodulation of interferometric fiber optic gyroscopes signals, based on the calculation of the mean value of the negative cycles of the measured photodetector signal from sinusoidally modulated Sagnac gyroscopes. The developed signal processing circuit was implemented and tested in a laboratory, and it was possible to detect signals as low as 5 microrad. Experimental results measured in a 890 m fiber optic coil gyroscope equipped with the developed circuit showed that the proposed circuit, when compared to the widely used and mature lock-in amplifier technique, presented a 5.1 dB higher signal-to-noise ratio. The circuit is also very stable with the temperature, since a very low drift of 0.04 degrees /h degrees C was measured in a complete gyroscope system. The Brazilian research sounding rocket VSB-30 is currently being equipped with the developed demodulator circuit.
