ABSTRACT
Asthma is an inflammatory disease which affects millions of people worldwide. Therefore, it is necessary to search for new sources of therapies for the treatment of these patients in order to improve their quality of life. From content analysis of literature of new therapeutic targets, there are various targets and drugs reported to be promising for the treatment of asthma. Interleukins involved in inflammatory processes are often presented as candidate targets for new drugs. The action of such therapeutics would not only affect interleukins, but also their receptors. Small molecules (e.g. ligustrazine and SP600125) and large molecule antibodies (e.g. lebrikizumab, benralizumab, dupilumab) are being considered as novel agents for the pharmacotherapy of asthma. Therefore, through this research, we can see advances in the search for new targets and promising drugs to treat asthma. It is expected that these new drug candidates will eventually be approved and marketed so that asthma patients can use them to enhance their quality of life.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Asthma/drug therapy , Antibodies, Monoclonal/immunology , Antibodies, Monoclonal, Humanized/therapeutic use , Asthma/pathology , Humans , Immunoglobulin E/immunology , Immunoglobulin E/metabolism , Interleukins/immunology , Interleukins/metabolism , Protein Kinase Inhibitors/chemistry , Protein Kinase Inhibitors/metabolism , Protein Kinase Inhibitors/therapeutic use , p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors , p38 Mitogen-Activated Protein Kinases/metabolismABSTRACT
Objetivo: traçar o perfil de pacientes e os fatores relacionados à enteroparasitoses. Método: estudo casocontrole sobre enteroparasitoses, com modelo de Regressão Logística, promovendo associações entre quadro clínico, parasitoses identificadas, dados laboratoriais e medicamentos em uso, em pacientes atendidos no ambulatório de Gastroenterologia do Hospital Universitário Lauro Wanderley/HULW, João Pessoa/PB. Foram analisados 34 prontuários. Realizou-se análise descritiva e associativa entre as variáveis e a Regressão Logística. Resultados: as mulheres foram mais parasitadas e a faixa etária média foi de 56 anos. Os helmintos foram mais prevalentes, sendo predominantemente Schistosoma mansoni. Os métodos mais utilizados para exames coproparasitológicos foram o Hoffman e Kato-katz. Observaram-se fatores de proteção entre os sintomas gastrointestinais, diabetes, HAS, e diurético e fatores de risco comorbidades gastrointestinais, medicamento antiparasitário e gastroprotetor. Conclusão: parasitas patogênicos são relevantes em pacientes ambulatoriais. Os fatores identificados permitiram caracterizar os pacientes susceptíveis as intervenções de prevenção e controle de enteroparasitas.(AU)
Objective: to analyze the patients' profile and the factors related to intestinal parasites. Method: casecontrol study about intestinal parasites, with a Logistic Regression model, promoting associations between clinical conditions, identified parasites, laboratory data and medications used in patients treated at the Gastroenterology Clinic of the University Hospital Lauro Wanderley/HULW, João Pessoa/PB. 34 medical records were analyzed. A descriptive and associative analysis between the variables was performed, along with the Logistic Regression. Results: the women presented more parasites and the average age was 56 years. Helminthes were the most prevalent, predominantly Schistosoma mansoni. The methods used for parasitological examinations were Hoffman and Kato-katz. Protective factors between gastrointestinal symptoms, diabetes, SAH, diuretic and gastrointestinal comorbidity risk factors, anti-parasitic and gastroprotective drugs were observed. Conclusion: pathogenic parasites are relevant in outpatients. The identified factors allowed characterizing the susceptible patients, interventions for prevention and control of intestinal parasites.(AU)
Objetivo: describir el perfil de los pacientes y los factores relacionados con las enteroparasitosis. Método: estudio de los parásitos intestinales de casos y controles, con el modelo de Regresión Logística, promoviendo asociaciones entre el clínico, parásitos identificados, datos de laboratorio y medicamentos que se usan en los pacientes tratados en la clínica de Gastroenterología del Hospital Universitario Lauro Wanderley/HULW, João Pessoa/PB. Se analizaron 34 registros. Se realizaron el análisis descriptivo y asociativo entre las variables y la Regresión Logística. Resultados: las mujeres presentaron más parásitos y la edad media fue de 56 años. Los helmintos fueron más prevalentes, predominantemente con Schistosoma mansoni. Los métodos utilizados para los análisis parasitológicos eran Hoffman y Kato-Katz. Se observaron los factores de protección entre los síntomas gastrointestinales, la diabetes, la hipertensión, diuréticos y los factores de riesgo de comorbilidad gastrointestinal, medicamentos antiparasitarios y gastroprotectores. Conclusión: los parásitos patógenos son relevantes en pacientes ambulatorios. Los factores identificados permiten caracterizar los pacientes susceptibles, intervenciones para la prevención y el control de los enteropárasitos.(AU)
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Patients , Protozoan Infections , Health Profile , Helminthiasis , Intestinal Diseases, Parasitic , Case-Control Studies , Medical RecordsABSTRACT
The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Citrus/chemistry , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/psychology , Oils, Volatile/therapeutic use , Administration, Inhalation , Adult , Blood Pressure , Diazepam/therapeutic use , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Middle Aged , Odorants , Oils, Volatile/chemistry , Plant Extracts/therapeutic useABSTRACT
Este estudo tem como objetivo realizar uma revisão de literatura sobre a prevalência de enteroparasitoses na população infantil e principais modelos de decisão utilizados na tomada de decisão. Procedeu-se uma revisão sistemática, pela combinação dos descritores "doenças parasitárias", "crianças", "prevalência", "parasitic diseases", "children" e "prevalence", na Biblioteca Virtual de Saúde, nas bases de dados LILACS (Literatura em Ciências da Saúde) e SciELO (Scientific Eletronic Library Online), entre 2010 e 2014. Observou-se que os parasitos mais frequentes foram: Ascaris lumbricoides;Ancylostomidae;Trichuris trichiura;Giardia lamblia;Entamoeba coli;Endolimax nana. Em relação ao tipo de análise estatística utilizada, a regressão é a única considerada um modelo de tomada de decisão; as demais são técnicas capazes de gerar resultados. Conclui-se que Ascaris lumbricóides,Ancylostomidae,Trichuris trichiura,Giardia lamblia,Entamoeba coli eEndolimax nanasão os tipos que mais afetam a população. As análises estatísticas estão sendo feitas de forma pouco detalhada, quanto ao seu delineamento.
A review of the literature on the prevalence of enteroparasitosis in children and main decision models. A systematic review was undertaken by a set of descriptors: "parasite diseases", "children", "prevalence", in the Health Virtual Library at data bases LILACS (Literature in Health Science) and SciELO (Scientific Eletronic Library Online), between 2010 and 2014. The most frequent parasites were: Ascaris lumbricoides; Ancylostomidae; Trichuris trichiura; Giardia lamblia; Entamoeba coli; Endolimax nana. Regression statistical analysis was the single decision-taking model; all the others were capable of producing results. Results showed that Ascaris lumbricoides; Ancylostomidae; Trichuris trichiura; Giardia lamblia; Entamoeba coli; Endolimax nana are parasites that affect the children population. Statistical analysis is undertaken with few details with