[Apolipoprotein B100 as a risk factor of acute coronary syndrome and this risk factor effect on arterial hypertension in patients with ischemic heart disease].

AIM: To clarify correlations between an elevated concentration of apolipoprotein B100 (apoB) in blood plasma and risk of acute coronary syndrome (ACS); to study apoB level in hypertensive patients and its correlation with ischemic heart disease (IHD) risk in these patients. MATERIAL AND METHODS: Lipid serum spectrum (cholesterol, triglycerides (TG), lipoprotein a (Lpa) and apoB was studied in 456 patients with ACS by NYHA criteria, 119 patients with chronic IHD and 86 patients free of cardiovascular diseases (controls). All 575 patients with IHD were divided into those with and without hypertension (426 and 149 patients, respectively). RESULTS: Lpa was significantly higher in patients with ACS; apoB was higher in ACS and chronic IHD patients. ApoB was higher in IHD normotensive patients than in controls and higher in IHD hypertensive patients than in IHD normotensive patients and in the control group. Lpa in IHD hypertensive patients was significantly higher (p < 0.045) than in the controls as well as TG (p < 0.05). By the other parameters the groups did not differ. CONCLUSION: The blood plasma level of apoB higher than 130 mg/dl is an independent and significant risk factor of ACS in IHD patients especially at the age under 60. The level of apoB over 115 mg/dl is a significant risk factor of IHD. The significance of this lipid factor rises in concomitant hypertension.

[Evaluation of antianginal effects of running pulse magnetic field and drug therapy on the physical working capacity and hemodynamics in patients with stable angina pectoris]. / Otsenka antianginal'nogo vliianiia begushchego impul'snogo magnitnogo polia i farmakoterapii na fizicheskuiu rabotosposobnost' i gemodinamiku u bol'nykh so stabil'noi stenokardiei.

The effects of the running pulse magnetic field, antianginal drug therapy and their combinations on the physical capacity were compared in 60 patients with Functional Classes I-III stable angina pectoris. Monotherapy with the running pulse magnetic field was found to produce an antianginal effect in patients with Functional Classes I-II angina pectoris, but the efficacy of drug therapy increased when antianginal drugs were used in combination with running pulse magnetic field in patients with severe angina.

[The action of obzidan and oktadin on muscle blood flow during head-down tilt hypokinesia]. / Deistvie obzidana i oktadina na myshechnyi krovotok v usloviiakh antiortostaticheskoi gipokinezii.

The blood flow in the gastrocnemius muscle of healthy men was studied during 6-hour antiorthostatic hypokinesia at different angles (-7, -15, -22, -30 degrees) and also the possibility of correcting changes in hemodynamics during antiorthostatic hypokinesia was determined. The muscle blood flow was studied by the clearance method. A total of 72 tests were performed. The tested men received obsidan and octadine 30 minutes before taking the antiorthostatic position in doses of 80 and 12.5 mg for one intake respectively. The analysis of the clinical data showed that typical symptomatology develops during antiorthostatic hypokinesia with a significant decrease of the tissue blood flow in the gastrocnemius muscle at an increase of the angle of tilt. The results of the studies suggested that obsidan fails to improve the muscle blood flow and octadine leads to a greater slowing of the muscle blood flow that negatively influences the condition of the gastrocnemius muscle.

[Central hemodynamics of patients during an attack of bronchial asthma]. / Tsentral'naia genodinamika u bol'nykh vo vremia pristupa bronkhial'noi astmy.

The authors presented the results of a combined study of 100 patients with infectious-allergic bronchial asthma. During and after attacks of asphyxia parameters of central hemodynamics and pressure in the lesser circulation system were defined. The patients were divided into 3 groups with relation to cardiac output values. An increase in cardiac output and pressure elevation in the right ventricle were noted in the 1st group, the values of pressure of pulmonary artery obstruction slightly raised. The absence of a marked increase in cardiac output was observed in the 2nd group, however pressure in the arterial system of the lesser circulation increased in the period of asphyxia. A decrease in cardiac output and an increase in pressure in the system of the pulmonary artery were noted in the patients of the 3rd group during asthmatic attacks. Such changes in the hemodynamics of the patients with bronchial asthma during attacks of asphyxia led to an idea of a possible favorable reaction of the cardiovascular system in the 1st group, maximum effort of compensatory capabilities in the 2nd group and depletion of reserve function of the cardiovascular system in the 3rd group. An elevation of pressure of pulmonary artery obstruction in the patients of the 2nd and 3rd groups confirmed a possibility of development not only of right but also left ventricular circulatory insufficiency during an attack of bronchial asthma.

[Comparative study of the effect of trental, menthol and obzidan and their combinations on the function of the cardiorespiratory system in operators under extreme conditions]. / Sravnitel'noe izuchenie vliianiia trentala, mentola i obzidana i ikh kombinatsii na sostoianie kardiorespiratornoi sistemy u operatorov v ékstremal'nykh usloviiakh.

Effects of different drugs on parameters of gas exchange and central hemodynamics were studied during physical load in operators under antiorthostatic hypokinesia at an angle of 15 degrees. More significant tension of the cardiorespiratory system during physical load was found following administration of beta-blockers.

[Effect of Hemoclar on lipid metabolism and the clinical picture of ischemic heart disease]. / Vliianie gemoklara na lipidnyi obmen i kliniku ishemicheskoi bolezni serdtsa.

The article discusses the results of treatment of 38 patients suffering from ischemic heart disease with hemoclar given in a dose of 200 mg for 25-34 days. Ergometry was carried out and the values of lipid metabolism and creatine phosphokinase activity were studied before and after treatment. The drug caused noticeable decrease in the lipid level, mainly in types IIb and IV hyperlipoproteinemia. Medication with hemoclar was attended by a decrease in the frequency and strength of the anginal attacks and by a lesser increase in the activity of creatine phosphokinase during a load. No side-effects were recorded.

[Characteristics of hemodynamics of the lesser circulation in chronic pneumonia according to ergometric data]. / Osobennosti gemodinamiki malogo kruga krovoobrashcheniia u bol'nykh khronicheskoi pnevmoniei pri ergometrii.

Rheopneumographic examinations were conducted in 54 patients with chronic pneumonia (stage I and II pulmonary insufficiency) prior to and following exercise tests. It was demonstrated that in normal individuals physical exercises cause a compensatory increase of the pulmonary blood flow without elevating the pressure in the pulmonary circulation system. The progression of pulmonary insufficiency is accompanied by a reduction of the adaptation capacity of the heart, of the pulmonary vessels, by an increase of pulmonary hypertension, and impairment of the contractile function of the right ventricular myocardium. The severity of changes in the pulmonary system haemodynamics, as shown by rheopneumography, correlates with the disorders in the oxygen regimen (oxygen consumption and oxygen pulse).

[Early diagnosis of cardiac insufficiency with the spiroergometric method]. / Ranniaia diagnostika serdechnoi nedostatochnosti pri pomoshchi spiroérgometricheskogo metoda

Standard and submaximal physical load tests were contrasted in studying the functional state of the cardio-respiratory system in healthy individuals and in patients with coronary atherosclerosis, post-infarction cardiosclerosis, mitral lesions and cardiac-pulmonary insufficiency. The application of physical load tests of different types is shown to be instrumental in obtaining a mutually complementary information about the function of the cardiac-respiratory system and the degree of pulmonary and cardiac decompensation. The authors attach great importance to determining the ratio of an actual oxygen uptake to its proper values and suggest using this indicator, called by them performance capacity index, in quantitative appraisal of physical capacity to perform work. In recognizing early stages of circulatory insufficiency of considerable interest is determining the ratio of the venous blood concentration of lactate, pyruvate and some other biochemical factors to the amount of work done.