Polymorphisms in HIF-1alpha affect presence of lymph node metastasis and can influence tumor size in squamous-cell carcinoma of the glottic larynx.

BACKGROUND: HIF-1alpha plays a key role in the development and progression of cancer. Its polymorphic variants C1772T and G1790A have been associated with greater susceptibility to cancer and increased tumor progression. METHODS: We determined the distribution of these polymorphisms among 121 patients with glottic cancer and 154 healthy volunteers by PCR-RFLP. We also analyzed the relationship between the presence of these polymorphisms and various clinicopathologic variables. RESULTS: Advanced tumors (T3-T4) were associated with the TT variant (p = 0.036), which was present in 75 % of T4 tumors (p = 0.008). Among patients with nodal metastasis (N+), 41.7 and 22 % were carrying the TT and GA variants, respectively, compared with 9.4 and 2 % of the patients with no metastasis (N0), (p = 0.006 and p = 0.032). CONCLUSIONS: The presence of the TT and GA variants were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size.

Experiencia preliminar en un consultorio interdisciplinario de factores de riesgo aterogenico (FRA): Informe de los hallazgos relevantes en 756 pacientes asistidos a lo largo de un año / Preliminary experience in an interdisciplinary clinic about atherogenic risk factors (ARF): report of relevant findings in 756 patients treated along a year

Se presenta la primer experiencia recogida en el primer consultorio interdisciplinario para el estudio integral de los factores de riesgo aterogenico (FRA) en la Argentina. Se analizan los resultados preliminares de esta accion medica en la prevencion primaria y secundaria de la enfermedad aterosclerotica y se realizan recomendaciones basadas en los hallazgos relevantes del estudio

Experiencia preliminar en un consultorio interdisciplinario de factores de riesgo aterogénico (FRA): Informe de los hallazgos relevantes en 756 pacientes asistidos a lo largo de un año / Preliminary experience in an interdisciplinary clinic about atherogenic risk factors (ARF): report of relevant findings in 756 patients treated along a year

Se presenta la primer experiencia recogida en el primer consultorio interdisciplinario para el estudio integral de los factores de riesgo aterogénico (FRA) en la Argentina. Se analizan los resultados preliminares de esta acción médica en la prevención primaria y secundaria de la enfermedad aterosclerótica y se realizan recomendaciones basadas en los hallazgos relevantes del estudio(AU)

Estudio de prevalencia de microalbuminuria y macroproteinuria en diabéticos y su relación con otras complicaciones / A collaborative study on the prevalence of microalbuminuriaand macroproteinuria in diabetic patients and their relation to other complications

Se determinó la prevalencia de microalbuminuria(Mi) y macroproteinuria(Ma) y otras complicaciones en diabéticos en un estudio multicéntrico en la Argentina. Se entrevistaron 214 pacientes sin selección previa, se evaluó historia clínica, se dividió por tipo de diabetes. La Mi se realizó por radioinmunoanálisis o inmunoturbidimétrico la Ma por método sulfosalicílico. Se relacionaron con edad, antigüedad y prevalencia de hipertensión,dislipemia y retinopatía. Se aplicó para análisis el método estadístico DBase con programa EPI INFO 50. Se calcularon estadísticas descriptivas, se aplicó prueba de chi cuadrado con unnivel de significación p=0.05. La población insulinodependiente (DID)n73(34,1), la no insulinodependinte (DNID) n101(47,2), la insulinorrequiriente(DIR)n40(18,7), la edad promedio del DID 34,88+ 16,3; el DNID 64,27 + 9,83; DIR 61,85 + 9,37,lo que mostró una diferencia estadísticamente significativa para el DID con respecto al DNID y al DIR. La antigüedad de la diabetes no mostró diferencias significativas, lo mismo sucedió con la hemoglobina glicosilada para los diferentes grupos.La prevalencia de Mi fue 26,22,23.17,30 y la Ma fue 21,13, 10,9,26,66 respectivamente. El 19,20 careció de datos para la proteinuria. La prevalencia de hipertensión arterial fue para el DID 15.06,DNID 54,45,DIR 57.50, la dislipemia 13,69, 39,60,47,50 y retinopatía 35,10,24.757 y 57,50 respectivamente,la hipertensión y dislipemia mostraron diferencias estadísticamente significativas si se comparaba los DNID y DIR con respecto DID

Estudio de prevalencia de microalbuminuria y macroproteinuria en diabéticos y su relación con otras complicaciones / A collaborative study on the prevalence of microalbuminuriaand macroproteinuria in diabetic patients and their relation to other complications

Se determinó la prevalencia de microalbuminuria(Mi) y macroproteinuria(Ma) y otras complicaciones en diabéticos en un estudio multicéntrico en la Argentina. Se entrevistaron 214 pacientes sin selección previa, se evaluó historia clínica, se dividió por tipo de diabetes. La Mi se realizó por radioinmunoanálisis o inmunoturbidimétrico la Ma por método sulfosalicílico. Se relacionaron con edad, antig³edad y prevalencia de hipertensión,dislipemia y retinopatía. Se aplicó para análisis el método estadístico DBase con programa EPI INFO 50. Se calcularon estadísticas descriptivas, se aplicó prueba de chi cuadrado con unnivel de significación p=0.05. La población insulinodependiente (DID)n73(34,1), la no insulinodependinte (DNID) n101(47,2), la insulinorrequiriente(DIR)n40(18,7), la edad promedio del DID 34,88+ 16,3; el DNID 64,27 + 9,83; DIR 61,85 + 9,37,lo que mostró una diferencia estadísticamente significativa para el DID con respecto al DNID y al DIR. La antig³edad de la diabetes no mostró diferencias significativas, lo mismo sucedió con la hemoglobina glicosilada para los diferentes grupos.La prevalencia de Mi fue 26,22,23.17,30 y la Ma fue 21,13, 10,9,26,66 respectivamente. El 19,20 careció de datos para la proteinuria. La prevalencia de hipertensión arterial fue para el DID 15.06,DNID 54,45,DIR 57.50, la dislipemia 13,69, 39,60,47,50 y retinopatía 35,10,24.757 y 57,50 respectivamente,la hipertensión y dislipemia mostraron diferencias estadísticamente significativas si se comparaba los DNID y DIR con respecto DID (AU)

[Benefits of physical exercise in the elderly]. / Beneficios del ejercicio fisico en la tercera edad.

Certain aspects regarding benefits provided by physical exercise in the elderly are reported. A. group of 100 elderly subjects from the medical office No. 13 of "Dr. Carlos J. Finlay" Teaching Polyclinics were numbered and a survey was applied analysing age, sex, time and frequency of physical exercise. Benefits and satisfaction provided by physical training and results obtained are reported in this work. A remarkable improvement in health status of elderly subjects was found; 52% reported to feel well and 48% to feel not bad. Regarding symptoms, 100% had joint pain; 89% improved with physical exercise. From the total number of patients who received drugs for different conditions, 36% stopped medication and 47% reduced the dosage. Support and care by the family doctor and the nurse represent a very significant aspect for elderly persons.

[The alcoholization process in Latin America. Critical analysis of biomedical and sociological production, 1970-1980 (2)]. / El proceso de alcoholización en América Latina. Análisis crítico de la producción biomédica y sociológica, 1970-1980 (2).

This work analyses the bibliographical production in the sociological and biomedical fields on alcoholization generated within and for Latin America during the seventies. This production is characterized by a unilaterally "pathologizing" outlook, which contrasts with the outlook dominant in the socio-anthropological fields, and which was analysed in a previous work. Empirical and factorial outlook dominate, in both, theory and methodology. They stress again an approach whose serious limitations have already been shown. The dominant technical elements--the sociological and epidemiological inquest--keep on being utilized, in spite of the many criticisms which they have received. Data obtained not only bears little relevance on the problem, but also stresses facts at a level of depth which is not justified, and do not justify, the theoretical framework of analysis. In spite of the fact that unsystematized empirical data and specific research which has been undertaken in other regional areas have made reference to a continual deficit on the part of the health team for the diagnosis and treatment of the alcoholization process; we hardly have any research which can throw light on the scientific and ideological limitations of medical and paramedical actions. Besides, we do not have a systematic analysis of alternative therapeutic strategics. All bibliographical publications refers, in a very biased way, the process of alcoholization to the lower population strata, without any critical reflection on that association. The biomedical dimension, although it utilizes conceptions and viewpoints which have been taken from anthropological and sociological production, this appropiation has meant a modification, which, in fact, has caused a split between the two dominant productions in Latin America: the biomedical and the anthropological one. This split replicates the conflict between models, that operates within other national and international contexts.

El proceso de alcoholizacion en America Latina. Analisis critico de la produccion biomedica y sociologica, 1970-1980 (segunda parte). / The alcoholization process in Latin America. Critical analysis of biomedical and sociological production, 1970-1980 (2nd part)

En este trabajo se analiza la produccion bibliografica sobre el proceso de alcoholizacion desde el punto de vista de la sociologia y la biomedicina, generada en y para America Latina durante la decada de los '70. En esta produccion se observa el dominio de un enfoque unilateralmente "patologizante", que contrasta con el enfoque dominante de la produccion socioantropologica analizada en un trabajo anterior

El proceso de alcoholización en América Latina. Análisis crítico de la producción biomédica y sociológica, 1970-1980 (2). / [The alcoholization process in Latin America. Critical analysis of biomedical and sociological production, 1970-1980 (2)]

This work analyses the bibliographical production in the sociological and biomedical fields on alcoholization generated within and for Latin America during the seventies. This production is characterized by a unilaterally [quot ]pathologizing[quot ] outlook, which contrasts with the outlook dominant in the socio-anthropological fields, and which was analysed in a previous work. Empirical and factorial outlook dominate, in both, theory and methodology. They stress again an approach whose serious limitations have already been shown. The dominant technical elements--the sociological and epidemiological inquest--keep on being utilized, in spite of the many criticisms which they have received. Data obtained not only bears little relevance on the problem, but also stresses facts at a level of depth which is not justified, and do not justify, the theoretical framework of analysis. In spite of the fact that unsystematized empirical data and specific research which has been undertaken in other regional areas have made reference to a continual deficit on the part of the health team for the diagnosis and treatment of the alcoholization process; we hardly have any research which can throw light on the scientific and ideological limitations of medical and paramedical actions. Besides, we do not have a systematic analysis of alternative therapeutic strategics. All bibliographical publications refers, in a very biased way, the process of alcoholization to the lower population strata, without any critical reflection on that association. The biomedical dimension, although it utilizes conceptions and viewpoints which have been taken from anthropological and sociological production, this appropiation has meant a modification, which, in fact, has caused a split between the two dominant productions in Latin America: the biomedical and the anthropological one. This split replicates the conflict between models, that operates within other national and international contexts.

El proceso de alcoholizacion en America Latina. Analisis critico de la produccion biomedica y sociologica, 1970-1980 (segunda parte). / The alcoholization process in Latin America. Critical analysis of biomedical and sociological production, 1970-1980 (2nd part)

En este trabajo se analiza la produccion bibliografica sobre el proceso de alcoholizacion desde el punto de vista de la sociologia y la biomedicina, generada en y para America Latina durante la decada de los 70. En esta produccion se observa el dominio de un enfoque unilateralmente "patologizante", que contrasta con el enfoque dominante de la produccion socioantropologica analizada en un trabajo anterior

[Socio-anthropology of the alcoholization process in Latin America, 1970-1980 (1)]. / Socioantropología del proceso de alcoholización en América Latina, 1970-1980 (primera parte).

A review is made of the bibliographical production on the process of alcoholization that has been generated from History and Anthropology in Latin America during seventies. This revision is undertaken on the basis of a model which attempts a theoretical and methodological systematization of that production. Such a model presupposes a review for each of the areas of knowledge mentioned before: a) the definition of the problem, b) the aetiological conceptions, c) the most usually found indicators and variables, d) the functions, e) the consequences, f) the social groups and strata, g) solutions, h) dominant theoretical outlooks, i) methodologies and techniques, j) areas most commonly under research, k) problem areas not under research. The revision gives to rise them idea that both areas of knowledge consider alcohol as an "instrument" or "tool", as a mediator; that the perception of the process of alcoholization--especially in anthropological works--is not seen negatively, but its functions are emphasized, especially those which are recognized as "integrative" ones. In spite of the fact that anthropological and historical production adds up to about 30% of total production between 1960 and 1980, it has had a very low weight in the strategics that medical practice, psychiatry and psychology have devised towards alcoholism.

Socioantropologia del proceso de alcoholizacion en America Latina, 19701980 (primera parte). / Socio-anthropology of the alcoholization process in Latin America, 1970-1980 (1st part)

Se revee la produccion bibliografica que sobre el proceso de alcoholizacion en America Latina, se ha generado en el campo de la investigacion antropologica e historica en la decada de los anos setenta. La revision se realiza a partir de un modelo que pretende sistematizar teorica y metodologicamente dicha produccion. Dicho modelo supone reveer para cada una de esas disciplinas: a) la definicion del problema; b) las concepciones etiologicas; c) los indicadores y variables de mayor frecuencia; d) las funciones; e) las consecuencias; f) los grupos y estratos sociales; g) las soluciones; h) los enfoques teoricos dominantes; i) las metodologias y tecnicas; j) las areas investigadas preferencialmente; y k) las areas problematicas no investigadas

Socioantropología del proceso de alcoholización en América Latina, 1970-1980 (primera parte). / [Socio-anthropology of the alcoholization process in Latin America, 1970-1980 (1)]

A review is made of the bibliographical production on the process of alcoholization that has been generated from History and Anthropology in Latin America during seventies. This revision is undertaken on the basis of a model which attempts a theoretical and methodological systematization of that production. Such a model presupposes a review for each of the areas of knowledge mentioned before: a) the definition of the problem, b) the aetiological conceptions, c) the most usually found indicators and variables, d) the functions, e) the consequences, f) the social groups and strata, g) solutions, h) dominant theoretical outlooks, i) methodologies and techniques, j) areas most commonly under research, k) problem areas not under research. The revision gives to rise them idea that both areas of knowledge consider alcohol as an [quot ]instrument[quot ] or [quot ]tool[quot ], as a mediator; that the perception of the process of alcoholization--especially in anthropological works--is not seen negatively, but its functions are emphasized, especially those which are recognized as [quot ]integrative[quot ] ones. In spite of the fact that anthropological and historical production adds up to about 30

of total production between 1960 and 1980, it has had a very low weight in the strategics that medical practice, psychiatry and psychology have devised towards alcoholism.

Socioantropologia del proceso de alcoholizacion en America Latina, 19701980 (primera parte). / Socio-anthropology of the alcoholization process in Latin America, 1970-1980 (1st part)

Se revee la produccion bibliografica que sobre el proceso de alcoholizacion en America Latina, se ha generado en el campo de la investigacion antropologica e historica en la decada de los anos setenta. La revision se realiza a partir de un modelo que pretende sistematizar teorica y metodologicamente dicha produccion. Dicho modelo supone reveer para cada una de esas disciplinas: a) la definicion del problema; b) las concepciones etiologicas; c) los indicadores y variables de mayor frecuencia; d) las funciones; e) las consecuencias; f) los grupos y estratos sociales; g) las soluciones; h) los enfoques teoricos dominantes; i) las metodologias y tecnicas; j) las areas investigadas preferencialmente; y k) las areas problematicas no investigadas

Miocardiopatía alcohólica. Informe de un caso / Alcoholic myocardiopathy. Report of a case

Se presentan los resultados clínicopatológicos de un paciente con miocardiopatía alcohólica. Se hace revisión bibliográfica de dicha afección(AU)

Acción simpaticopléjica de la dehidroemetina / Sympathicoplegic action of dehidroemetine

Se demuestra la acción de la dehidroemetina como bloqueador de la liberación de la Noradrenalina por las terminaciones postganglionares simpáticas, sin bloqueo de los receptores alfa-adrenérgicos, ni los receptores nicotínicos de la placa neuromuscular, utilizando para ello distintas técnicas de farmacología experimental. Afirmándose que la modificación de la estructura química de la Dehidroemetina no afecta la acción simpáticoplejica de la emetina, siendo sin embargo la Dehidroemetina de menor toxicidad y de más fácil y seguro manejo en terapéutica(AU)