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1.
Lancet ; 2(8517): 1183-5, 1986 Nov 22.
Article in English | MEDLINE | ID: mdl-2877326

ABSTRACT

In 27 Puerto Rican patients with tropical sprue proven by intestinal biopsy and clinical response to folic acid, HLA type was determined with a microcytotoxicity assay. 25 of these patients had at least one antigen of the Aw-19 series (p = 10(-10)). The strongest association was with Aw-31, for which the relative risk was 10.6 (p = 1.2 X 10(-6)). The absence of a B-locus or haplotype effect suggests a marker association only, rather than an immune association.


Subject(s)
HLA Antigens/genetics , HLA-A Antigens , Sprue, Tropical/genetics , Disease Susceptibility , Gene Frequency , Genetic Markers , Humans , Puerto Rico , Sprue, Tropical/immunology
2.
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