[Osteoarthritis and analgesic-antiphlogistic therapy. Preliminary report on the tolerability and efficacy of nabumetone treatment]. / Osteoartrosi e terapia analgesico-antiflogistica. Rapporto preliminare di tollerabilità ed efficacia di un trattamento a base di nabumetone.

Twenty patients (1 male, 19 females, mean age 62, range 45-86 years) with acute stage articular disorders (gonarthritis, coxarthritis, humero-scapular periarthritis) were treated for 10 days with 1 g nabumetone daily. Marked pain was present in all cases. Therapeutic activity was assessed on the basis of changes of objective clinical signs and symptoms: spontaneous pain, functional limitation, edema or swelling of the joint involved. The obvious analgesic and antiinflammatory action of the drug was accompanied by a fair degree of functional recovery. This latter aspect becomes even more relevant if the type of patient treated is considered; the majority of subjects were in fact suffering from chronic osteoarthritic-degenerative pathology. Systemic tolerability, as assessed by a number of laboratory and clinical tests, was good since no changes of liver, kidney and cardiocirculatory function parameters were observed. Local tolerability (with special reference to gastroenterologic and other side effects) was excellent in 12 cases, good in 7, and fair in one (slight dryness of throat spontaneous regression after 3 days). Nabumetone treatment was considered highly effective in 2, effective in 5, fairly effective in 9 e scarcely effective in 2 cases, ineffective in 2 (due to drop-out).