Subject(s)
Kidney/pathology , Lymph Nodes/pathology , Spleen/pathology , Thymic Factor, Circulating/pharmacology , Thymus Hormones/pharmacology , Animals , Animals, Newborn , Cell Division , Female , Mesentery/pathology , Mice , Mice, Inbred NZB , Plasma Cells/cytology , T-Lymphocytes/pathology , ThymectomySubject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Salicylates/pharmacology , Analgesics , Animals , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/toxicity , Arthritis, Experimental/drug therapy , Dogs , Edema/drug therapy , Female , Fluorobenzenes/pharmacology , Fluorobenzenes/therapeutic use , Fluorobenzenes/toxicity , Gastrointestinal Hemorrhage/chemically induced , Humans , In Vitro Techniques , Lethal Dose 50 , Male , Mice , Peptic Ulcer/chemically induced , Platelet Aggregation/drug effects , Rabbits , Rats , Salicylates/therapeutic use , Salicylates/toxicity , Time FactorsABSTRACT
The present report confirms the findings by Steinberg et al. (9) that repeated intraperitoneal injections of poly I:C (3 mug/g, three times per wk, 40-52 doses) enhanced the incidence and severity of glomerular lesions that occur spontaneously in NZG/NZW mice and also increased the development of circulating antibody against nucleic acids. This effect was minimal when only six intraperitoneal doses were given in 1 mug/g amount at weekly intervals. Intranasal administration of poly I:C (0.2 mug/g, three times per wk, 40 doses) or six doses of the drug (1 mug/g weekly) caused no apparent potentiation of glomerular response. ICR/Ha mice, which do not suffer from the spontaneously occurring disease, were uneffected by poly I:C treatment except for occasional development of antibody against poly I:C or DNA.
Subject(s)
Antibodies/analysis , DNA/immunology , Kidney Glomerulus/drug effects , Mice, Inbred NZB , Poly I-C/adverse effects , RNA/immunology , Administration, Intranasal , Animals , Drug Evaluation, Preclinical , Female , Injections, Intraperitoneal , Male , Mice , Mice, Inbred ICR , Poly I-C/administration & dosageABSTRACT
Ten of 16 rabbits restrained 6 h daily for 35 days developed focal to diffuse degeneration of the sciatic nerves. Very small necrotic areas also were found in the skeletal muscles of seven of 16 rabbits, but the muscle lesions did not correlate with the nerve changes.
