ABSTRACT
[This corrects the article DOI: 10.1155/2016/4078215.].
ABSTRACT
Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 µg/kg/day of granulocyte colony stimulating factor (G-CSF), B: nineteen with CFA + G-CSF, and C: twenty only with G-CSF when the WBC count exceeded 10 × 10(9)/L. The average number of MNC/kg body weight (BW)/aphaeresis was 0.4 × 10(8) (0.1-1.4), 2.25 × 10(8) (0.56-6.28), and 1.02 × 10(8) (0.34-2.5) whereas the average number of CD34+ cells/kg BW/aphaeresis was 0.18 × 10(6)/kg (0.09-0.34), 1.04 × 10(6) (0.19-9.3), and 0.59 × 10(6) (0.17-0.87) and the count of CFU/kg BW/aphaeresis was 1.11 × 10(5) (0.31-2.12), 1.16 × 10(5) (0.64-2.97), and 1.12 × 10(5) (0.3-6.63) in groups A, B, and C, respectively. The collection was better in group B versus group A (p = 0.007 and p = 0.05, resp.) and in group C versus group A (p = 0.08 and p = 0.05, resp.). The collection of PBPCs was more effective in the group mobilized with CFM + G-CSF when the WBC exceeded 10 × 10(3)/µL in terms of MNC and CD34+ cells and there was no toxicity of the chemotherapy.
ABSTRACT
BACKGROUND: In 2009, 17.9 % of hospital morbidity by malignant tumors in México corresponded to hematological malignancies, mainly acute leukemia. Some studies suggest a seasonal pattern, since most of the cases are registered during summer. Our objective was to estimate the relationship between the different subtypes of acute leukemia with the age when the disease arose, and the season of the year. METHODS: Retrospective and observational study, based on records of a hematology department from January 2006 to April 2012. Only the patients diagnosed with de novo acute leukemia, stratified according to the French-American-British classification, were included. Seasonal analysis was performed using Edward's periodic model. RESULTS: The study included 833 acute leukemia cases: 48 % of women (400), and 52 % of men (433). Median age was 36.2 ± 19.8 years. Acute lymphoblastic leukemia predominated over acute myeloblastic leukemia subtype M4 (p < 0.05), and we found differences (p < 0.01) between lymphoblastic and myeloblastic leukemias: 32.3 and 41.8. Despite the existence of pronounced peaks in the time series, they did not repeat periodically. CONCLUSIONS: The most common variety of acute leukemia was lymphoblastic type L2, followed by myeloblastic type M4. People over 40 years of age were the most affected. A seasonal pattern of acute leukemias was not observed.
INTRODUCCIÓN: en 2009, 17.9 % de la morbilidad hospitalaria por tumores malignos en México correspondió a neoplasias hematooncológicas, principalmente a leucemias agudas. Algunos estudios sugieren un patrón estacional al presentarse más casos durante el verano. El objetivo de esta investigación fue estimar la relación entre los diferentes subtipos de leucemia aguda, la edad de presentación y la estación del año. MÉTODOS: estudio retrospectivo, observacional, que se llevó a cabo con los registros de enero de 2006 a abril de 2012 en un servicio de hematología; se incluyeron únicamente los pacientes con diagnósticos de novo de leucemia aguda, estratificada según la clasificación de la Asociación Franco-Américo-Británica. El análisis de temporalidad se realizó con el modelo periódico de Edward. RESULTADOS: de los 833 casos de leucemia aguda, 48 % correspondió al sexo femenino y 52 % al masculino; la edad media fue de 36.2 ± 19.8 años. Predominó la leucemia aguda linfoblástica sobre la mieloblástica subtipo M4 (p < 0.05) y se encontraron diferencias (p < 0.01) entre la linfoblástica y la mieloblástica: 32.3 y 41.8. A pesar de existir picos pronunciados en la serie temporal, no se repitieron periódicamente. CONCLUSIONES: la variedad más frecuente fue la L2, seguida por la M4. El grupo de edad más afectado fue el de los mayores de 40 años. No existió patrón estacional de presentación de las leucemias agudas.
Subject(s)
Leukemia, Myeloid, Acute/classification , Leukemia, Myeloid, Acute/epidemiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/classification , Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Infant , Male , Mexico , Middle Aged , Retrospective Studies , Seasons , Young AdultABSTRACT
Haploidentical hematopoietic cell transplantation using CD34(+) cells depleted of T lymphocytes by the CliniMACS is a treatment for hematological malignancy. We report on four Mexican children, three with acute lymphocytic leukemia and one with chronic myelocytic leukemia, who was transplanted with 12 × 10(6) CD34(+) stem cells/kg body weight (98% of purity) with a follow-up of 9½ years. The engraftment was successful in three of the four children. All showed cytomegalovirus reactivation, and one died because of graft rejection and infectious complication. The risk of infections was a major problem.