1.
J Pharm Biomed Anal
; 39(3-4): 757-63, 2005 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-15927438
ABSTRACT
An impurity present in calcium folinate (N5-formyl-5,6,7,8-tetrahydrofolic calcium salt) active pharmaceutical ingredient (API) was detected by high-performance liquid chromatography (HPLC). Through analysis by HPLC coupled with atmospheric-pressure chemical-ionization mass spectrometry (APCI-MS), a structure for this impurity was postulated and then proved by chemical synthesis.
