ABSTRACT
This work is devoted to the study of 22 dossiers of persons who have presented with clinical signs following taking a drug. The study was confined to patients in whom the symptoms had as origin a hypersensitivity (true or non-specific by histamine release). This study has allowed analysis of the value of several serological tests (measurement of leukotrienes, activation of basophils and T specific lymphocytes) in diagnosis and so to define the path to take that is best adapted to each case. The conclusion presents an agreement between the suspected diagnosis, after allergy enquiry and prick-tests, and the results of serological tests.
Subject(s)
Basophil Degranulation Test , CD8-Positive T-Lymphocytes/immunology , Drug Eruptions/diagnosis , Leukotriene C4/blood , Lymphocyte Activation/drug effects , Adolescent , Adult , Aged , Aged, 80 and over , Drug Eruptions/blood , Evaluation Studies as Topic , Female , Histamine Release/drug effects , Humans , Leukotriene C4/metabolism , Male , Middle AgedABSTRACT
Patients with respiratory pathologies in the forms of tracheitis, rhino-sinusitis, and asthma sometimes have symptoms of gastro-oesophageal reflux, that should be taken into consideration in order to treat the co-factors associated with the etiopathology. However, these patients, because of their respiratory handicaps, are frequently unwilling to submit themselves to traumatic investigations. Oesophageal scintigraphy, because of its perfect tolerance and reliability, seems to be an examination that is adapted to the situation to resolve this dilemma.
Subject(s)
Esophagus/diagnostic imaging , Gastroesophageal Reflux/diagnostic imaging , Adolescent , Adult , Aged , Asthma/complications , Child , Child, Preschool , Female , Gastroesophageal Reflux/complications , Humans , Male , Middle Aged , Radionuclide Imaging , Tracheitis/complicationsABSTRACT
The work is devoted to the study of 82 dossiers of patients who were treated by immunotherapy (IT) to hymenoptera venoms, following various manifestations. The study has permitted analysis of the value of measurement of specific immunoglobulins, both IgE and IgG4 (1), in following IT in patients who were treated for at least three years. It especially emphasized the usefulness of adopting management that is appropriate to the clinical and biological characteristics of each patient.