ABSTRACT
HIV/syphilis co-infection is common because both conditions affect similar risk groups. HIV interferes with the natural history of syphilis, which often has atypical clinical features and nervous system involvement in the early stage of disease. We report the case of an HIV-positive patient with secondary syphilis, scaling palmoplantar keratoderma, scrotal eczema, balanitis and urethritis mimicking Reiter's syndrome. Immunohistochemistry using polyclonal antibodies against Treponema pallidum revealed the presence of spirochetes, associated with the paretic form of parenchymal neurosyphilis. The patient was given crystalline penicillin, with complete resolution of dermatological and neurological symptoms, and no sequelae.
Subject(s)
Arthritis, Reactive/pathology , Coinfection/pathology , HIV Infections/pathology , Neurosyphilis/pathology , Adult , Anti-Bacterial Agents/therapeutic use , Biopsy , Diagnosis, Differential , Humans , Immunohistochemistry , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Male , Neurosyphilis/drug therapy , Penicillin G/therapeutic use , Treatment OutcomeABSTRACT
HIV/syphilis co-infection is common because both conditions affect similar risk groups. HIV interferes with the natural history of syphilis, which often has atypical clinical features and nervous system involvement in the early stage of disease. We report the case of an HIV-positive patient with secondary syphilis, scaling palmoplantar keratoderma, scrotal eczema, balanitis and urethritis mimicking Reiter’s syndrome. Immunohistochemistry using polyclonal antibodies against Treponema pallidum revealed the presence of spirochetes, associated with the paretic form of parenchymal neurosyphilis. The patient was given crystalline penicillin, with complete resolution of dermatological and neurological symptoms, and no sequelae.
.Subject(s)
Adult , Humans , Male , Arthritis, Reactive/pathology , Coinfection/pathology , HIV Infections/pathology , Neurosyphilis/pathology , Anti-Bacterial Agents/therapeutic use , Biopsy , Diagnosis, Differential , Immunohistochemistry , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Neurosyphilis/drug therapy , Penicillin G/therapeutic use , Treatment OutcomeABSTRACT
Synovial sarcomas are rare malignant tumors affecting mainly young adults, presenting as a slow growth mass located in deep soft tissues of extremities, near the joints. In this report a 34-year-old male patient, presented an ulcerovegetative lesion on the right wrist which was completely excised. Histopathology and immunohistochemistry confirmed synovial sarcomas with poorly differentiated cells. This patient presented 11 months later with ipsilateral axillary lymph node metastasis, which emphasizes the unfavorable prognosis of this synovial sarcoma variant. The indolent growth pattern of this sarcoma justifies the well circumscribed initial stages, which progressively infiltrate adjacent structures with lung metastasis (80%) and lymph node involvement (20%) and thus corroborates the importance of early diagnosis and proper treatment.
Subject(s)
Sarcoma, Synovial/pathology , Skin/pathology , Soft Tissue Neoplasms/pathology , Wrist , Adult , Biopsy , Humans , Immunohistochemistry , MaleABSTRACT
Synovial sarcomas are rare malignant tumors affecting mainly young adults, presenting as a slow growth mass located in deep soft tissues of extremities, near the joints. In this report a 34-year-old male patient, presented an ulcerovegetative lesion on the right wrist which was completely excised. Histopathology and immunohistochemistry confirmed synovial sarcomas with poorly differentiated cells. This patient presented 11 months later with ipsilateral axillary lymph node metastasis, which emphasizes the unfavorable prognosis of this synovial sarcoma variant. The indolent growth pattern of this sarcoma justifies the well circumscribed initial stages, which progressively infiltrate adjacent structures with lung metastasis (80%) and lymph node involvement (20%) and thus corroborates the importance of early diagnosis and proper treatment.
Subject(s)
Adult , Humans , Male , Sarcoma, Synovial/pathology , Skin/pathology , Soft Tissue Neoplasms/pathology , Wrist , Biopsy , ImmunohistochemistryABSTRACT
Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Adenocarcinoma, Sebaceous/pathology , Facial Neoplasms/pathology , Sebaceous Gland Neoplasms/pathology , Adenocarcinoma, Sebaceous/etiology , Adult , Biopsy , Facial Neoplasms/etiology , Humans , Immunohistochemistry , Male , Risk Factors , Sebaceous Gland Neoplasms/etiologyABSTRACT
Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.
Adenocarcinoma sebáceo é um tumor anexial raro que pode envolver a pele e é dividido em ocular, mais comum e extraocular, mais raro. Relatamos o caso de um paciente com diagnóstico de Síndrome da Imunodeficiência Adquirida que desenvolveu um adenocarcinoma sebáceo extra-ocular, na face, volumoso, de rápido crescimento. A literatura tem sugerido que pacientes transplantados e portadores do vírus da imunodeficiência humana têm um excesso de risco para o desenvolvimento de tumores anexiais, incluindo o Adenocarcinoma sebáceo.
Subject(s)
Adult , Humans , Male , Acquired Immunodeficiency Syndrome/complications , Adenocarcinoma, Sebaceous/pathology , Facial Neoplasms/pathology , Sebaceous Gland Neoplasms/pathology , Adenocarcinoma, Sebaceous/etiology , Biopsy , Facial Neoplasms/etiology , Immunohistochemistry , Risk Factors , Sebaceous Gland Neoplasms/etiologyABSTRACT
Dermoid cysts or mature cystic teratomas are mesenchymal neoplasms most commonly found in the ovaries, but which may occur in any location along the pathways of ectodermal cell migration. They are rarely seen in the pancreas, where they show a slight preference for the pancreatic head. We report a case of dermoid cyst of the pancreas in a 69-year-old male patient, discussing the epidemiology, clinical presentation, diagnosis and treatment of this neoplasm. Since preoperative diagnosis is difficult, given its rarity in this site, it is usually diagnosed by histopathology of the specimen.
Cistos dermoides ou teratomas císticos maduros são neoplasias mesenquimais comumente encontradas nos ovários, mas que podem ocorrer em qualquer via de migração das células ectodérmicas. No pâncreas, a ocorrência é rara, sendo mais comum na cabeça pancreática. Relata-se caso de cisto dermoide do pâncreas em paciente masculino de 69 anos, discutindo-se epidemiologia, clínica, diagnóstico e tratamento dessa neoplasia, pouco suspeitada no pré-operatório devido à sua raridade nessa topografia; geralmente, é diagnosticada apenas pelo exame histopatológico da peça cirúrgica.
