ABSTRACT
The purpose of this article is show the role of proton magnetic resonance spectroscopy (MRS), associated with magnetic resonance images, in the study of non-neoplastic disorders, helping in diagnosis and better characterization of the nature of the lesion. Herein, we analyzed single voxel proton spectroscopy in eight different non-neoplastic lesions, displayed in six categories (infectious, ischaemic, demyelinating, inflammatory, malformation of development and phacomatosis). The presence or the ratios of signal intensities brain tissue metabolites observed with this technique (N-acetyl aspartate, choline, creatine, lactate and lipids) helped in their differentiation with neoplastic lesions and helped in correct diagnosis. In infectious diseases, signals of acetate, succinate and amino acids were also important. In conclusion, proton MRS is a noninvasive method, very useful as an additional technique to define the nature of non-neoplastic encephalic lesions.
Subject(s)
Brain Diseases/diagnosis , Magnetic Resonance Spectroscopy/methods , Protons , Adolescent , Adult , Child , Child, Preschool , Female , Humans , MaleABSTRACT
O propósito deste artigo é mostrar o valor da espectroscopia de hidrogênio associada a imagens de ressonância magnética (RM), no estudo de lesões encefálicas não neoplásicas, ajudando no diagnostico e na melhor caracterização de grupos etiológicos. Analisamos espectroscopias de hidrogênio com voxel único em oito diferentes doenças não neoplásicas, divididas em seis categorias (infecciosas, isquêmicas, desmielinizates, inflamatórias, malformações do desenvolvimento cortical e facomatoses). A presença e as relações entre a intensidade do sinal dos metabólitos do tecido nervoso observados com esta técnica (N-acetil aspartato, colina, creatina, lactato e lipídios) ajudaram na diferenciação de lesões neoplásicas e permitiram o diagnostico correto. Nas doenças infecciosas, os sinais do acetato, succinato e aminoácidos também foram importantes. Concluímos que a espectroscopia do hidrogênio por RM é um método não invasivo muito útil como técnica adicional para definir a natureza não neoplásica de lesões encefálicas.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Brain Diseases/diagnosis , Magnetic Resonance Spectroscopy/methods , ProtonsABSTRACT
The purpuse of this study was to evaluate MRI findings in a group of patients with Wilson's disease, trying to establish possible correlations between clincial and image data. Sixteen patients (8 males and 98 females), with ages ranging from 11 to 50 years, and duration of illness ranging from 5 months to 32 years, were submitted to MRI in a 1.5T System. Four patients were asymptomatic, 4 had mild neurological findings, 2 were moderatedly affected and the remaining 6 had a severe form of the disease. All patients were receiveing D-penicillamine by the time of the study. The most symptomatic patients presented five or more sites of abnormalities on MRI. the putamen was affected in all symptomatic individuals and one asymptomatic and 11 of them presented dystonia on neurological examination. A striking feature was the peripheral localization of putaminal hyperintense lesions on T2 weighted images. In eight cases, striatum or "substantia nigra lesions explained parkinsonism observed on neurological examination. MRI seems to be an efficient method to study neurological involvement of Wilson's disease allowing some interesting anatomo-clincial correlations
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Cerebrum/pathology , Hepatolenticular Degeneration/diagnosis , Time Factors , Hepatolenticular Degeneration/pathology , Magnetic Resonance ImagingABSTRACT
Resumo: No período de dezembro de 1986 a abril de 1987,a ocorrência de aflatoxicose casou a morte de 560 coelhos na regiäo de Londrina - PR. PAra a diagnose do problema foram analisadoas 6 amostras de raçäo coletadas em diferentes propriedades. A presença de aflatoxina B1, foi detectada em uma amostra de triguilho na concentraçäo de 33 ugKg, duas amostras de raçäo granulada na concentraçäo de 110 e 44 ugKg, e a contagem total de bolores foi de 8,2 x 10(elevado a +6); 2,8 x 10(elevado a +6) e 8,0 x 10(elevado a +3) UFC/G, respectivamente. Na amostra de triguilho predominou Aspergillus flavuis com 6,7 x 10(elevado a +6) UFC/G, enquanto que nas amostras de raçäo granulada, indica que o tratamento térmico pode ter eliminado o fungo, mas näo inativou a toxina (au)