Pathological findings in congenital diaphragmatic hernia on necropsy studies: A single-center case series.

INTRODUCTION: Congenital diaphragmatic hernia (CDH) is associated with high mortality rates and significant pulmonary morbidities. The objective of this study was to delineate the histopathological features observed in necropsies of CDH patients and correlate these with their clinical manifestations. METHODS: We retrospectively reviewed the postmortem findings and corresponding clinical characteristics in eight CDH cases from 2017 to July 2022. RESULTS: The median survival time was 46 (8-624) hours. Autopsy reports showed that diffuse alveolar damage (congestion and hemorrhage) and hyaline membrane formation were the primary pathological lung changes observed. Notably, despite significant reduction in lung volume, the lung development appeared normal in 50% of the cases, while lobulated deformities were present in three (37.5%) cases. All patients displayed a large patent ductus arteriosus (PDA) and a patent foramen ovale, resulting in increased right ventricle (RV) volume, and myocardial fibers appeared slightly congested and swollen. The pulmonary vessels indicated thickening of the arterial media and adventitia. Lung hypoplasia and diffuse lung damage resulted in impaired gas exchange, while PDA and pulmonary hypertension led to RV failure, subsequent organ dysfunction and ultimately death. CONCLUSIONS: Patients with CDH typically succumb to cardiopulmonary failure, a condition driven by a complex interplay of pathophysiological factors. This complexity accounts for the unpredictable response to currently available vasodilators and ventilation therapies.

Childhood trauma is associated with social anhedonia and brain gray matter volume differences in healthy subjects.

The present study tested the effects of childhood trauma (CT) on trait social anhedonia (SA) and on gray matter volume (GMV) and explored the possible relationships among CT, SA and brain GMV. Forty-three healthy individuals with experience of moderate-to-severe CT and sixty-eight individuals with no or low CT participated in the present study. Trait SA was evaluated using the Revised Social Anhedonia Scale. GMV was measured using voxel-based morphometry. Participants with moderate-to-severe CT had elevated trait SA, as well as brain volumetric differences in left inferior parietal lobule (IPL), left precuneus, right insula, left superior temporal gyrus, and left middle occipital gyrus extending into middle temporal gyrus relative to participants with no or low level of CT. CT was also found to be positively correlated with GMV in right dorsolateral prefrontal cortex (DLPFC) and bilateral precuneus. Partial mediation effect of GMV in left IPL and right DLPFC on the relationship between CT and trait SA was significant. These findings suggest that CT may have effects on trait SA and on GMV of widespread brain regions. GMV differences in DLPFC and left IPL may mediate the effect of CT on trait SA, although this needs to be verified by future longitudinal studies.