Study of reactive dyes and their hydrolyzed forms in a real trichromatic dyeing process by capillary electrophoresis with UV detection.

Detecting the concentration of reactive dyes and their hydrolyzed products is essential for controlling the dyeing process and is an important guide for upgrading and improving textile dyeing technology. In this study, capillary electrophoresis (CE) with UV detection was for the first time applied in a real trichromatic dyeing process to provide qualitative and quantitative determination of reactive dyes and their hydrolyzed forms. Here, three original reactive dyes (SES-Cl-red-195, SES-Cl-yellow-145, and SES-Cl-blue-194), their vinyl sulfone forms (VS-Cl-red-195, VS-Cl-yellow-145, and VS-Cl-blue-194), and complete hydrolyzed forms (HES-OH-red-195, HES-OH-yellow-145, and HES-OH-blue-194) could be baseline separated in our developed BGE comprised of 10.0 mol/L Na2B4O7, 15% (V/V) ACN at pH 8.50 that adjusted by 0.50 mol/L H3BO3. The LODs (S/N = 3) of nine analytes ranged from 0.3 to 1.3 mg/L, and high sensitivities were achieved with UV detection. The RSDs of peak area and migration time were in the ranges of 1.4-3.8% and 0.39-1.29%, which indicated the CE methods were reliable for studying different dye forms in complex dye baths, and for evaluating dyeing process quality. Thus, the percentage of dye-uptake in single and trichromatic combination dyes was calculated based on the concentration of the original and their vinyl sulfone and hydrolyzed forms, and the result was consistent with the traditional UV-Vis method.

Hindrance or facilitator? The economic consequences of national demonstration eco-industrial parks in China.

Many countries attach great importance to the green, low-carbon, and circular development of industrial parks. China is one of them and has entered an exploration journey of national demonstration eco-industrial parks (NDEIPs). However, the impact of the transformation of industrial parks into NDEIPs on local economic development still remains a mystery. To address this issue, we develop an empirical study using a combination of the multi-period difference-in-differences method and the propensity score matching method based on the panel data for 266 cities in China from 2001 to 2021. The results show that industrial parks becoming NDEIPs promotes cities' economic development. This conclusion still holds after a series of robustness tests, such as the reverse causality test and the placebo test. Moreover, the park heterogeneity tests show that the economic consequences vary according to differences in levels, industry types, life cycle phases, and the degree of foreign firm agglomeration. The city heterogeneity tests show that the economic consequences differ based on administrative levels, innovation capabilities, technology industrialization, and environmental friendliness. The spatial heterogeneity tests show that the economic consequences differ according to geographical location and whether situated in the Yangtze River Economic Belt. The policy upgrading heterogeneity tests show that the economic consequences differ during the process of policy upgrading and transformation. In addition, the mechanism tests reveal that green innovation, human capital level, and firm attractiveness mediate the relationship between industrial parks becoming NDEIPs and cities' economic development. This study provides a new perspective for understanding the economic effects of the transformation of industrial parks into NDEIPs, and provides a reference for the government on how to maximize these economic effects.

New energy vehicles' technology innovation coordination strategy based on alliance negotiation under dual credit policy.

The development of new energy vehicles (NEVs) is one of the effective ways to alleviate carbon emissions, environmental pollution, and energy scarcity in the transportation sector. The Chinese government has innovatively proposed the "dual credit policy," but it is still a hot topic whether it can promote the NEVs' technological innovation. In this study, we construct game models and obtain the technological innovation strategies for NEVs under the dual credit policy, considering that the NEV supply chain contains one manufacturer and N suppliers. Further, we construct bargaining game models and study how to encourage manufacturers and suppliers to enhance technological innovation, realize supply chain coordination, and give the alliance strategy to maximize suppliers' profit. We found that the dual credit policy can effectively stimulate technological innovation, and the higher the credit price or technological innovation credit factor, the higher the technical level of NEVs. The findings could guide the government to adjust and revise the policy. Second, we found that the bargaining games could coordinate the NEV supply chain so that decentralized enterprises can achieve optimal technological innovation under centralized decision-making. Third, we found that suppliers can improve their profits by choosing a suitable alliance strategy under the manufacturer's different negotiating power.

The allocative efficiency of construction land quota in rural China: a perspective of bidders' behavior and regret psychology.

The construction land quota pricing mechanism with cost plus pricing method is not sufficient to reflect its intrinsic value. This diminishes the willingness of farmers to voluntarily reclaim abandoned residential and other rural construction land, leading to suboptimal efficiency in rural land utilization and an excessive squandering of rural land resources. Thus, a sequential auction model with two stages for complementary goods was constructed, which considered the synergic characteristics between the land and quota. Further, regret psychology of bidder was considered in the case of winning or losing. A rational pricing mechanism has been developed to allocate construction land quotas, aiming to enhance farmers' motivation to the vacant homesteads of reclamation and revitalizing the stock of rural construction land. The results revealed that the regret psychology in the case of winning would decrease the transaction price of the quota, i.e., the greater the perceived regret in the case of winning, the more significant the reduction in the bidding price offered. Moreover, the regret psychology in the event of losing/failure would increase the transaction price of quota. Furthermore, publishing only the winner's price after the auction leads to the highest price of the quota offered by the bidder. In contrast, publishing only the loser's bidding price leads to the lowest transaction price of the quota offered by the bidder. In addition, the fee for delayed construction would increase the bidding price of the construction land quota. Therefore, local governments should consider announcing only the winner of price after the quota auction has ended. In addition, imposing a fee for delayed construction would enhance the transaction price of land quota, increase farmers' revenue from land reclamation, and incentivize farmers to reclaim unused rural land.

A novel single-base deletion of the RUNX Family Transcription Factor 2 gene associated with cleidocranial dysplasia.

Cleidocranial dysplasia (CCD) is a rare, autosomal dominant hereditary disorder characterized by skeletal malformations and dental abnormalities. The purpose of this study was to explore the functional role of a novel mutation in the pathogenesis of CCD. Genomic DNA was extracted from peripheral blood mononuclear cells collected from family members of a Chinese patient with CCD. An analysis of their RUNX Family Transcription Factor 2 (RUNX2) gene sequences was performed by PCR amplification and Sanger sequencing. The function of the mutant RUNX2 was studied by bioinformatics, real-time PCR, western blotting, and subcellular localization analysis. Sanger sequencing identified a novel single-base deletion (NM_001024630.4:c.132delG;NP_001019801.3: Val45Trpfs* 99) in the RUNX2 gene present in the Chinese patient with CCD. In vitro, functional studies showed altered protein localization and increased expression of mutant RUNX2 mRNA and mutant Runt-related transcription factor 2 (RUNX2). Luciferase reporter assay demonstrated that the novel RUNX2 mutations significantly increased the transactivation activity of RUNX2 on the osteocalcin gene promoter. In conclusion, we identified a patient with sporadic CCD carrying a novel deletion/frameshift mutation of the RUNX2 gene and performed screening and functional analyses to determine the cause of the CCD phenotype. This study provides new insights into the pathogenesis of CCD.3.

Artificial porous heterogeneous interface for all-solid-state sodium ion battery.

Solid sodium-ion batteries are regarded as promising candidates for next-generation energy storage systems with high energy density and good safety. However, the large interface resistance and dendrite growth between sodium and solid electrolytes, especially at high current densities, severely limits their development. Herein, an artificial porous heterogeneous interface is constructed between sodium and the NASICON electrolyte Na3Hf2Si2PO12 (NHSP). This indicated that the porous heterogeneous interface with high-efficiency ion-electron transfer properties could effectively reduce the interface resistance, inhibit dendrites, and realize good rate performance. The symmetric cell with porous heterogeneous interface could cycle stably for more than 2000 h at 0.2 mA cm-2 at room temperature, and the critical current density reached 2.7 mA cm-2. Our study provides a promising direction for creating a stable interface that meets both the long-cycle and high-rate requirements for all-solid-state sodium-ion batteries.

Factors Influencing Intergovernmental Cooperation on Emission Reduction in Chengdu-Chongqing Urban Agglomeration: An Evolutionary Game Theory Perspective.

In this study, we introduced the realistic problem of a dynamic carbon tax, built several evolutionary game models for cooperative emission reduction by local governments, and determined the factors that influence governments' willingness to cooperate in emission reduction. The findings revealed that, first, the probability of governments opting for cooperative emission reduction strategies increases at different rates depending on the benefits and costs of cooperation. Second, externalities influence governments' willingness to cooperate in emission reduction during cooperative carbon emission reduction. Furthermore, the emergence of a free-riding situation reduces the effectiveness of intergovernmental cooperation in reducing carbon emissions. Third, carbon tax policy can influence the likelihood that local governments will choose cooperative emission reduction, and different carbon tax sizes have different effects on their willingness to choose cooperative emission reduction.

Blockade of IL-6 inhibits tumor immune evasion and improves anti-PD-1 immunotherapy.

Long-standing inflammatory bowel disease predisposes to the development of colorectal cancer (CRC). Interleukin (IL) -6, a pivotal link between chronic inflammation and tumor progression, has recently been recognized as a potential therapeutic target. The effect of IL-6 on proliferation and metastasis of CRC by activating the STAT3 pathway has been widely demonstrated in recent years, but few on mediating tumor immune evasion. In this study, we found that IL-6 was remarkably overexpressed in CRC and its elevation was associated with a poor prognosis. We studied CRC tumorigenesis in vivo by inoculating MC38 tumors and induced-CRC model via AOM/DSS (azoxymethane/dextransulfate sodium) in IL-6 deficient (IL-6-/-) and wild-type (WT) mice and found that IL-6-/- mice were less susceptible to develop tumors, compared to WT mice. We detected CD8+ T cells via immunofluorescence and found they exhibit high expression in tumor of IL-6-/- mice. High level of IL-6 was found in colitis model, with down-regulation of MHC-I molecules. In in vitro experiments, we found that IL-6 may act as a negative regulator in IFNγ-STAT1-MHC-I signaling. In addition, vivo trials also confirmed that MHC-I mRNA level was negatively related to the existence of IL-6. Furthermore, the blockade of IL-6 also activated CD8+T-cell accumulation and led to the high PD-L1 expression in CRC, which can sensitize animals to anti-PD-1 therapy. Our study provides a research basis for the significant role of IL-6 in tumor evasion and highlights a novel target to improve the efficacy of immunotherapy.

Effective guide for behaviour of farmers in the withdrawal of rural homesteads: An evolutionary game-based study.

In this study, we determined how farmers can be effectively encouraged to withdraw from their idle homesteads, in addition to revitalising the rural construction land stock and realising the market-oriented allocation of land resources. We constructed an evolutionary game model under three scenarios: without penalty mechanism; with a static penalty mechanism; and with a dynamic penalty mechanism. Further, we explicitly describe the strategic behaviours and dynamic evolution processes of local governments and farmers during withdrawal from their rural homesteads. According to the results of the evolutionary stable strategy, under effect of the dynamic penalty mechanism, the strategy systems formed by local governments as well as farmers can gradually converge and stabilise after short-term shocks, compared with that under the no penalty and static penalty mechanisms. Overall, the penalty mechanism mitigates the instability in the game process during participants' incremental changes and strategy choices, while the dynamic mechanism is optimal. Both static and dynamic penalty mechanisms influence the binary equilibrium strategies of local governments as well as farmers, and farmers' strategies evolve towards this state of withdrawal from their homesteads with increasing penalty. When the model is dynamically improved, the probability of farmers' withdrawal of their homesteads increases with increasing penalty. Thus, clearly, the establishment of a penalty mechanism can promote stability of the participants' system; higher penalty implies higher motivation for farmers to withdraw their idle homesteads, enabling revitalisation of the rural stock of construction land and promotion of the optimal allocation of land resource elements.

Export trade structure transformation and countermeasures in the context of reverse globalization.

With the development of economic globalization, the problem of unequal distribution of globalization dividends among and within countries has become increasingly serious, and reverse globalization has a great impact on the national economy and export trade. This paper uses the KOF Globalization Index and the world input-output tables in World Input-Output Database (WIOD), and empirically studies the transformation of a country's export trade and export structure in the context of reverse globalization from the perspectives of world, country, industry, subdivided manufacturing and service industry. The results show that reverse globalization has a significant non-linear negative effect on economic development and export trade. Compared with developed and European Union (EU) countries, the exports of developing and non-EU countries are more affected by reverse globalization shocks. Reverse globalization has the greatest inhibition on the secondary industry exports, followed by the tertiary industry. The suppressive effects on the exports of 12 subdivided manufacturing and 14 subdivided service in China are significantly greater than that of the United States, but most of sub-industry exports in the United States are more sensitive. Besides, China's exports of high-product-complexity industry such as metal products, medicinal chemicals, electrical and optical products and mechanical equipments are greatly affected by reverse globalization, while the exports of water transportation, construction, land transportation are relatively less restrained.

In Situ Construction of a Liquid Film Interface with Fast Ion Transport for Solid Sodium-Ion Batteries.

Solid sodium-ion batteries (SSIBs) are considered as one of the promising energy storage systems because of their high safety and high energy density. However, the sodium metal anode presents poor wettability with a solid electrolyte, resulting in high interface impedance and dendrite growth, which severely limits their application in practice. Herein, a novel liquid film (Na-BP) interface is constructed between sodium and solid electrolyte (Na3Hf2Si2PO12) with an excellent kinetic mass transfer ability and good fluidity, which could guarantee a close contact and fast charge transfer at interface. The symmetric cells with the designed interface show a high-rate and long-cycle performance and could cycle stably more than 1000 and 700 h at 0.2 and 0.5 mA cm-2, respectively. The critical current density of the cells can reach 3.6 mA cm-2 at room temperature, which is the highest value in similar works.

Development of a Personalized Recommendation System for E-Commerce Products for Distributed Storage Systems.

Because the distributed storage system is based on network technology, it can store data in multiple independent low-cost physical storage devices, and it is also suitable for large-capacity storage, so it has become more and more popular. Today, common applications of distributed storage systems include cloud storage services, data center storage services, and P2P storage services. Typical ones are GFS, HDFS, OceanStore, and Dynamo. Due to regional and economic differences, the development level of global e-commerce (b2c) is very inconsistent. b2c contains the following key tags: buying and selling, which is the core of the website platform. E-commerce provides business users with transparent information and high-quality cheap products. Logistics is the basic guarantee for customers to execute transactions, and it is also a strict indicator of the website platform. There will be many visits during the operation of the e-commerce system, and the number of users in the early stage will increase exponentially. A safe and efficient e-commerce system can provide users with one-stop transaction support and convenient transaction processes. The personalized recommendation system has formulated some rules for certain fields, based on these rules, and defined certain types of knowledge for certain items to meet the needs of certain users and use the defined reasoning rules to generate recommendation results.

Designing a Novel Electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 for All-Solid-State Na-O2 Batteries.

Sodium-air battery has great development potential due to its high energy density and high safety. However, most previous works are based on liquid electrolyte or polymer electrolyte, which will inevitably result in safety hazards such as electrolyte leakage and sodium dendrite growth. Herein, an all-solid-state Na-O2 battery based on a well-designed NASICON-type electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 , which has high ionic conductivity (2.39 × 10-3 S cm-1 ) and excellent chemical stability, is developed. Collaborating with the reasonable humidity of the atmosphere, the battery shows good cycle stability. This research demonstrates that NASICON-type electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 has good application potential for all-solid-state Na-O2 batteries and lays a solid foundation on the material preparation and optimization for developing high-energy sodium-air batteries.

Auction mechanism on construction land quota with selection on land location.

Due to unreasonable pricing, farmers have low enthusiasm for reclaiming their homesteads, which can be used to generate construction land quota. This paper studies how to design a feasible pricing mechanism to stimulate the enthusiasm of farmers. First, we analyze the practice that the local government gives the developers with quota the selection, the right to select the location of the land to be auctioned. Then, applying sequential auction theory, we propose first- and second-price sealed-bid sequential auction models and design quota auction pricing mechanisms. Through theoretical and numerical analysis, we obtain the equilibrium strategy and analyze the impact of selection and on developers' bidding pricing on quota. The results show that the selection can enhance the developer's quota bidding price and farmers' income. And the higher the value of selection to the developer, the higher the quota bidding price and farmer's income. Contrarily, the larger the number of developers, the smaller the quota bidding price and farmers' income. Finally, the quota bidding price and farmers' income in the second-price sealed-bid sequential auction are higher than in the first-price sealed-bid sequential auction.

Supply chain coordination strategy for NEVs based on supplier alliance under dual-credit policy.

In this paper, we assume that the supply chain for new energy vehicles (NEVs) consists of a manufacturer and N parts suppliers, considering that the R&D investment of both manufacturer and suppliers will affect the market demand of NEVs and NEVs credit, we construct decentralized and centralized decision-making models under the dual-credit policy to study the R&D investment strategy of supply chain enterprises. Furthermore, considering that suppliers can form alliances, we establish bargaining game models under the conditions of the non-alliance and alliance of suppliers, and discuss the coordination strategy for the NEVs supply chain. It is found that, under the dual-credit policy, the higher the credit coefficient of technology improvement, the higher the transaction price of credits, and the higher the R&D investment of supply chain. Dual-credit policy can effectively encourage NEVs supply chain to increase R&D investment, improve NEV technology level, and improve the profit of supply chain. Under the dual-credit policy, the increment profit distribution strategy based on a bargaining game model can coordinate the NEVs supply chain. When suppliers separately negotiate with the manufacturer, bringing the negotiation sequence forward, the supplier can get more profits. However, as the manufacturer has the right to determine the negotiation sequence, the supplier can only get the profit of the last round of negotiation, and the manufacturer can get excess profit. Forming a suppliers alliance can solve this problem effectively, and increase the profit of all suppliers when the alliance`s negotiating power is improved to a certain threshold.

An improved sequential auction with complementarity for pricing the construction land quota.

The paradox between idle homesteads in rural areas and the shortage of construction land in urban areas is concerning. Hence, local governments encourage farmers to reclaim their idle homesteads and farmlands to generate quota. However, the current quota price, which is based on the land reclamation cost, is often inadequate to motivate farmers. This study proposed that the construction land quota and construction land are complementary items, and hence, their pricing should be studied simultaneously instead of independently. Therefore, the classical sequential auction model with complementarity was improved using the core characteristics of quota transactions and those were applied to design optimal pricing mechanisms. Subsequently, the influence of relevant factors on the bidding price was analysed. The results indicated that the bidding price decreases with an increase in the number of bidders and that a bidder's revenue is at a loss when they acquire the quota but fail to obtain the land; hence, the revenue probability is lost. However, bidding prices increase when the fine of delaying construction increases. To raise the quota price and encourage relatively more farmers to reclaim their idle homesteads, local governments should appropriately increase the delaying construction fines or repurchase the quota at a premium from the bidder who acquires the quota but fails to obtain the land, which is beneficial for easing conflict between construction land demands and farmland protection and for promoting the sustainable development of China's social economy.

Impact of product subsidies on R&D investment for new energy vehicle firms: Considering quality preference of the early adopter group.

Different consumer groups accept new energy vehicles sequentially from the perspective of innovation diffusion theory, and the early adopter group has recently been identified. By assuming that the density of early adopters is increasing at minimum acceptable quality thresholds, this paper proposes a vertical quality differentiation model of product R&D with product subsidies. The impact of product subsidies on the R&D investment of new energy vehicle firms is discussed. We show that the early adopters' characteristics may affect the stagnant marginal R&D investment of new energy vehicle firms by increasing sales, which determines the impact mechanism of product subsidies. For firms with decreasing marginal R&D investments, insufficient R&D investments result from financial constraints. If insufficient R&D resources deter firms from conducting R&D, substantial unit subsidies invariably incentivize firms to spend their entire R&D budget. Firms with increasing marginal R&D investments, insufficient R&D profits, or financial constraints are prevented from increasing R&D investment. Product subsidies generally have a crowding-in effect on firms not subject to financial constraints, and this effect increases with the unit subsidy. However, the existence of a crowding-in effect may require sufficiently large unit subsidies. In both situations, product subsidies cannot modulate financial constraints if the firm has spent its entire R&D budget. In the first situation, we also show that product subsidies should be replaced by a funding support policy. In contrast, the second situation shows that a funding support policy should be coordinated with product subsidies.

Occurrence and risk assessment of heavy metals in an urban river supplied by reclaimed wastewater.

Heavy metals in reclaimed water are a global problem that leads to ecological risks for the replenishment water body. This study investigated concentrations and ecological risks posed by heavy metals in SH River, Beijing, which is supplied by reclaimed water. Results showed that Cr was not detected in the sample, Cd and Pb exceeded threshold values according to regulations by 1.19% and 25.00%, respectively. The characterization of temporal and spatial of heavy metals was studied. The potential ecological risks posed by heavy metals in SH River were found to be low and safe. The risk decreased in the order Pb > Cu > Zn > Ni > Cd > As by comprehensive index assessment; this changed to Pb > Cd > As > Ni > Cu > Zn according to potential ecological risk assessment. Pb posed the greatest ecological risks and was identified as most contaminated metal. According to discussion of sampling sites and water quality, it was proposed that reclaimed water and exogenous discharges were the main sources of the heavy metals identified. This should be considered when developing catchment management strategies for heavy metals elimination and protection of the aquatic environment. If a higher level of ecological risk management is required, Pb, Cd, and Cu should be considered first and should be removed in situ through ecological remediation methods. PRACTITIONER POINTS: Reclaimed water and exogenous discharges were the main sources of the heavy metals identified. The potential ecological risks posed by heavy metals in SH River were found to be low and safe. The risk decreased in the order Pb > Cu > Zn > Ni > Cd > As by comprehensive index assessment. Potential ecological risk assessment showed Pb > Cd > As > Ni > Cu > Zn. Pb posed the greatest ecological risks and was identified as most contaminated metal.

Design of spherical aberration free liquid-filled cylindrical zoom lenses over a wide focal length range based on ZEMAX.

A systematic design idea for liquid-filled cylindrical zoom lenses with ideal imaging quality over a wide focal length range is introduced in detail. The PWC method is used to calculate the initial structure parameters of the zoom lenses, and the optical design software ZEMAX is used to eliminate the spherical aberration at different focal lengths. Lenses named SLCL-Doublet are finally designed, which are formed by a symmetric liquid-core cylindrical lens (SLCL) filled with variable refractive index (RI) liquid and a doublet cylindrical lens capable of significantly weakening the spherical aberration. The focal length of the SLCL-Doublet continuously decreases from 101.406 mm to 54.162 mm as the liquid RI changes from 1.3300 to 1.5000. Calculated over 75% of the full aperture, the root mean square (RMS) spot radius of the SLCL-Doublet is always less than 7 µm over the whole focal length range, and the peak-to-valley wavefront error remains below the λ/4 limit when the focal length ranges from 62.373 mm to 65.814 mm, within which the lenses approach the diffraction limit, demonstrating improvement in the optical performance over that of previously designed liquid-core cylindrical lenses. The sources of potential fabrication and installation errors in the practical implementation of the SLCL-Doublet are also analyzed in detail. The SLCL-Doublet is demonstrated to be characterized by high imaging quality and easy installation, which enriches the types of core optical element for measuring the liquid RI and liquid diffusion coefficient and provides guarantee for improving the measurement accuracy.

CYP2J2/EET reduces vulnerability to atrial fibrillation in chronic pressure overload mice.

Growing evidence has well established the protective effects of CYP2J2/EET on the cardiovascular system. The aim of the present study was to determine whether CYP2J2/EET has a preventive effect on atrial fibrillation (AF) and to investigate the underlying mechanisms. Wild-type mice were injected with or without AAV9-CYP2J2 before abdominal aortic constriction (AAC) operation. After 8 weeks, compared with wild-type mice, AAC mice display higher AF inducibility and longer AF durations, which were remarkably attenuated with AAV9-CYP2J2. Also, AAV9-CYP2J2 reduced atrial fibrosis area and the deposit of collagen-I/III in AAC mice, accompanied by the blockade of TGF-ß/Smad-2/3 signalling pathways, as well as the recovery in Smad-7 expression. In vitro, isolated atrial fibroblasts were administrated with TGF-ß1, EET, EEZE, GW9662, SiRNA Smad-7 and pre-MiR-21, and EET was demonstrated to restrain the differentiation of atrial fibroblasts largely dependent on Smad-7, due to the inhibition of EET on MiR-21. In addition, increased inflammatory cytokines, as well as activated NF-κB pathways induced by AAC surgery, were also significantly blunted by AAV9-CYP2J2 treatment. These effects of CYP2J2/EET were partially blocked by GW9662, the antagonist of PPAR-γ. In conclusion, this study revealed that CYP2J2/EET ameliorates atrial fibrosis through modulating atrial fibroblasts activation by disinhibition of MiR-21 on Smad-7, and attenuates atrial inflammatory response by repressing NF-κB pathways, reducing the vulnerability to AF, and CYP2J2/EET exerts its role at least partially through PPAR-γ activation. Our findings might provide a novel upstream therapeutic strategy for AF.