ABSTRACT
A one-pot route for the preparation of TiO2@carbon nanocomposite from Ti4+/polysaccharide coordination complex has been developed and shown advantages in operation, cost, environment, etc. However, the photodegradation rate of methylene blue (MB) needs to be improved. N-doping has been proven as an efficient means to enhance photodegradation performance. Thus, the present study upgraded the TiO2@carbon nanocomposite to N-doped TiO2@carbon nanocomposite (N-TiO2@C) from Ti4+-dopamine/sodium alginate multicomponent complex. The composites were characterized by FT-IR, XRD, XPS, UV-vis DRS, TG-DTA, and SEM-EDS. The obtained TiO2 was a typical rutile phase, and the carboxyl groups existed on N-TiO2@C. The photocatalyst consequently showed high removal efficiency of MB. The cycling experiment additionally indicated the high stability of N-TiO2@C. The present work provided a novel route for preparing N-TiO2@C. Moreover, it can be extended to prepare N-doped polyvalent metal oxides@carbon composites from all water-soluble polysaccharides such as cellulose derivatives, starch, and guar gum.
Subject(s)
Carbon , Nanocomposites , Methylene Blue , Titanium , Dopamine , Alginates , Spectroscopy, Fourier Transform Infrared , CatalysisABSTRACT
TiO2-based materials have been developing rapidly as eco-friendly photocatalysts, but the inherent defects limited their application, such as rapid recombination of photogenerated electrons and wide bandgap. To obtain high-efficient TiO2/carbonaceous photocatalysts (TiO2/C), we prepared the nanocomposite by carbonizing titanium alginate coordination compound and studied their photocatalytic performance against methylene blue (MB) under simulated sunlight irradiation. The resultant nanocomposites were characterized by FT-IR, XPS, XRD, SEM-EDS, TG-DTG, UV-DRS, and N2 adsorption-desorption analysis. The carbon mainly existed in the outer layer of TiO2/C composites, contributing to the optical sensibilization. As a result, the degradation efficiency of sample TiO2/C-20 to MB could reach 97.47% within 15 min under simulated sunlight. The samples also possessed high stability, proved by the 0.72% reduction in photodegradation ratio after five cyclic tests. The present study proved the feasibility of preparing photocatalyst from titanium-alginate coordination compound and provided an extensible approach for preparing high-efficiency photocatalysts from a polysaccharide-based coordination compound.
Subject(s)
Nanocomposites , Titanium , Alginates , Catalysis , Methylene Blue , Nanocomposites/radiation effects , Spectroscopy, Fourier Transform Infrared , Titanium/radiation effectsABSTRACT
Self-healing hydrogels with pH-responsiveness could protect loaded drugs from being destroyed till it arrives to the target. The pectin-based hydrogel is a candidate due to the health benefit, anti-inflammation, antineoplastic activity, nontoxicity, and biospecific degradation, et al. However, the abundant existence of water-soluble branched heteropolysaccharide chains influenced its performance resulting in limitation of the potential. In the present study, we prepared a series of self-healing pectin/chitosan hydrogels via the Diels-Alder reaction. Moreover, pectin/chitosan composite hydrogel was prepared as a contrast. By comparison, it can be seen that the Diels-Alder reaction greatly improved the cross-linking density of hydrogels. The self-healing experiments showed excellent self-healing performance. In different swelling mediums, significant transformation in the swelling ratio was shown, indicating well-swelling property, pH- and thermo-responsiveness. The drug loading and release studies presented high loading efficiency and sustained release performance. The cytotoxicity assay that showed a high cell proliferation ratio manifested great cytocompatibility.
Subject(s)
Chitosan/chemistry , Drug Carriers/chemistry , Hydrogels/chemistry , Pectins/chemistry , Animals , Cell Line , Chitosan/chemical synthesis , Chitosan/toxicity , Citrus/chemistry , Cycloaddition Reaction , Drug Carriers/toxicity , Drug Liberation , Fluorouracil/chemistry , Furans/chemical synthesis , Furans/chemistry , Furans/toxicity , Hydrogels/chemical synthesis , Hydrogels/toxicity , Hydrogen-Ion Concentration , Kinetics , Maleimides/chemical synthesis , Maleimides/chemistry , Maleimides/toxicity , Mechanical Phenomena , Mice , Pectins/chemical synthesis , Pectins/toxicity , TemperatureABSTRACT
Injectable hydrogels with self-healing ability present great potential for drug delivery. They could be facilely implanted in vivo and maintained structural and functional integrity till the hydrogel arriving at target sites. Herein, a series of injectable and self-healing composite hydrogel were developed as delivery vehicles for anti-cancer drug. The hydrogels were obtained with varying ratios of oxidized pectin/chitosan to nano γ-Fe2O3, which present excellent injectable, self-healing, magnetic, high biocompatible, and anti-cancer properties. The nano γ-Fe2O3 with particle size of about 0.25 µm loaded on the surface of hydrogel. Magnetic hysteresis loops of the hydrogel presented S-shape over the applied magnetics and the MS value was 4.86 emu/g. When pH dropped from 7.4 to 6.5 or temperature increased form 36 °C to 37 °C, the percentage increase in the swelling rate of OP4-400 reached to 35.89% and 25.13%, respectively. The composite hydrogels could continuously release water-soluble 5-FU for more than 12 h. In addition, the drug delivery systems indicated acceptable anti-cancer property though trace amounts of 5-FU were added in the hydrogel systems. The addition of γ-Fe2O3 could not only be beneficial to the targeting but also collectively enhance the anti-cancer property.
Subject(s)
Chitosan/pharmacology , Ferric Compounds/pharmacology , Hydrogels/pharmacology , Pectins/pharmacology , Antimetabolites, Antineoplastic/administration & dosage , Antimetabolites, Antineoplastic/pharmacology , Antineoplastic Agents , Chitosan/administration & dosage , Drug Carriers , Drug Liberation , Drug Screening Assays, Antitumor , Ferric Compounds/administration & dosage , Fluorouracil/administration & dosage , Fluorouracil/pharmacology , Humans , Hydrogels/administration & dosage , Hydrogels/chemical synthesis , Hydrogen-Ion Concentration , Injections , MCF-7 Cells , Materials Testing , Metal Nanoparticles/administration & dosage , Oxidation-Reduction , Pectins/administration & dosage , Solubility , Static Electricity , Temperature , WaterABSTRACT
The 3-aminopropyltriethoxysilane modified nano-carbon sphere (MNCS) was added into pectin-Ca2+ film to improve the controlled release properties of the pectin-based oral colon-specific drug delivery system (OCDDS). The FT-IR measurements indicated the successful modification of nano-carbon sphere via silylation reaction and the electrostatic interaction between the pectin molecules and MNCS in the composite film. The FE-SEM showed the pore structure when the MNCS was mingled with the pectin. The 5-fluorouracil (5-FU) was employed as the drug model and the controlled release properties of the corresponding OCDDSs were determined. The values of the encapsulation efficiency ranged from 30.1% to 52.6%. All composite film based OCDDSs presented higher encapsulation efficiency than single pectin-Ca2+ based OCDDS. The drug release studies emerged that almost all the OCDDSs from composite films presented better release properties than single pectin-Ca2+ based OCDDS. The sample C revealed best release performance with the cumulative release rate of 32.17%, 22.77% and 63.89% in the simulated gastric fluid, small intestinal fluid and colon fluid, respectively. In addition, the kinetics studies were performed to analyze the release data. The cytotoxicity assay indicated good biocompatibility of the composite carriers.
Subject(s)
Carbon/chemistry , Colon/metabolism , Drug Carriers/chemistry , Nanocomposites/chemistry , Nanospheres/chemistry , Pectins/chemistry , Administration, Oral , Fluorouracil/administration & dosage , Fluorouracil/chemistry , Gels , Organ Specificity , Propylamines/chemistry , Silanes/chemistryABSTRACT
Montmorillonite (MMT) presents nonocclusive lamellar structure which restricts the potential use for sustained drug release. To solve the limitation, the quaternized pectin (QP) was synthesized and firstly introduced to form QP-MMT hybrid film containing 5-FU. The Fourier transform infrared spectroscopy (FT-IR) and X-Ray diffraction (XRD) were employed to determine the variation of the functional group and crystallinity between pectin and QP. The resultant composite film was characterized by FT-IR, XRD and Field Emission Scanning Electron Microscope. The results of the characterization indicated that intercalation reaction happened in the blending process. The optimum film showed high value of drug encapsulation efficiency (36.50%) and loading efficiency (80.30%). The in vitro drug release studies revealed that the MMT significantly improved the sustained-release performance in all simulated mediums. The cumulative release rate of sample QP10-MMT0.1 was all around 20% in the first half-hour in all simulated mediums and sustained increased for more than 8 h. The cytotoxicity assay was performed to prove the great biocompatibility of QP-MMT hybrid film. The present study introduced a facile route to prepare the composite film which presented sustained drug release performance.
Subject(s)
Bentonite/chemistry , Drug Carriers/chemistry , Drug Design , Pectins/chemistry , Delayed-Action Preparations , Mechanical PhenomenaABSTRACT
A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (1H NMR, 13C NMR, 1H-1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.
Subject(s)
Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Diterpenes/chemistry , Diterpenes/pharmacology , Streptomyces/chemistry , Bacteria/drug effects , Diterpenes/metabolism , Esters/chemistry , Esters/pharmacology , Magnetic Resonance Spectroscopy , Molecular StructureABSTRACT
A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (H NMR, C NMR, H-H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.
