ABSTRACT
Drug-induced hepatotoxicity: clinical and biochemical features of 26 patients and a review of the literature. Drug-induced hepatotoxicity is a major cause of iatrogenic diseases. More than 1200 compounds are involved and can reproduce the full range of hepatic disorders. Clinical and biochemical features of 26 patients (13 men and 13 women, mean age 62 years) observed during a 6 years period were reported. The potential hepatotoxicity of some herbal remedies are described, emphasizing the relevance of misconception that herbs are devoid of toxic potential because they are natural products. Meticulous taking of patient history, drug history with specific queries about ingestion of herbal and dietary supplements, and the exclusion of other causes of liver disease are important for the early detection of drug-induced hepatotoxicity and rapid discontinuation of suspected drug(s).
Subject(s)
Chemical and Drug Induced Liver Injury/diagnosis , Chemical and Drug Induced Liver Injury/etiology , Dietary Supplements/adverse effects , Iatrogenic Disease , Adult , Aged , Aged, 80 and over , Drugs, Chinese Herbal/adverse effects , Early Diagnosis , Female , Humans , Liver Function Tests , Male , Middle Aged , Phytotherapy , Retrospective Studies , Withholding TreatmentABSTRACT
Focal nodular hyperplasia (FNH) of the liver is a benign disorder that usually occurs in women during their reproductive years. Multiple FNH is very rare. A case of multiple FNH of the liver occurring in a 34-year-old woman is described. FNH diagnosis was confirmed by means of US, CT, MR, scintigraphy and hepatic biopsy. There was no further change in either size or appearance of liver masses in the ensuing 6 years of follow-up.
Subject(s)
Focal Nodular Hyperplasia/diagnosis , Adult , Female , HumansABSTRACT
Multiple chondromatous hamartomas of the lung are extremely rare. We report a case of a 78 year-old man admitted to our service for a neurological syndrome associated with cerebral cancer. Chest-X-ray and computed tomography revealed multiple and bilateral pulmonary nodules. A metastatic carcinoma was initially taken into account but, in the light of natural history of the disease, clinical examination and CT-scan characteristics of the lesions, we formulated the final diagnosis of multiple bilateral chondromatous hamartomas of the lung.
Subject(s)
Hamartoma/diagnosis , Lung Diseases/diagnosis , Lung Neoplasms/diagnosis , Aged , Diagnosis, Differential , Humans , Male , Tomography, X-Ray ComputedABSTRACT
A case of acute cholestatic hepatitis associated with use of antiplatelet agent ticlopidine is reported. Hepatitis developed 3 weeks after the beginning of the drug in a 72 year old man submitted to coronary angioplasty and stent implantation for unstable angina. The close time relationship between the administration of this antiplatelet drug and the acute onset of liver damage, the exclusion of other hepatobiliary disease and the progressive normalisation of biochemical parameters following withdrawal of the drug strongly suggest that ticlopidine was involved in the pathogenesis of this syndrome.
