ABSTRACT
Quality of service is a major determinant of customer commitment to the organization. Therefore, it is important to understand the importance of service quality for the corporate image as well. In this study, the predicting roles of quality of service and customer experience have been unveiled in customer commitment through the mediating effect of corporate image. The population frame used in this study is the customers of logistic services providers in China. Total data from the 366 customers have been used to analyze the hypotheses formulated. The sample has been selected using convenience sampling and the software used for data analysis is Smart-PLS. The analytical technique used is partial least square structural equation modeling. Results of the study show that service quality and customer experience have a significant role in the customer commitment to the suppliers. In addition, it has also been found that service quality and customer experience have a major contribution to building the corporate image of the services suppliers. Further, corporate image played a significant mediating role in the relationship between service quality and customer commitment. The study has theoretically contributed to the body of literature by finding the importance of service quality for predicting customer commitment to the suppliers.
ABSTRACT
OBJECTIVE:To establish a method for the determination of related substances in Vildagliptin tablets. METHODS:HPLC method was adopted. The determination was performed on Xterra MS C18 column with mobile phase consisted of [phosphate buffer-water-acetonitrie-methanol(400 : 600 : 15 : 15,V/V/V/V)]-[phosphate buffer-acetonitrile-methanol(400 : 450 : 150,V/V/V)](gra-dient elution)at the flow rate of 1.2 mL/min. The detection wavelength was set at 210 nm and column temperature was 35 ℃. The sample size was 10 μL. RESULTS:The linear ranges were 18.80-188.0 μg/mL for impurity A(r=0.9995),22.64-226.4 μg/mL for impurity B(r=0.9996),21.74-217.4 μg/mL for impurity C(r=0.9997),19.12-191.2 μg/mL for impurity D(r=0.9998). The limits of detection were 4.18,2.68,1.12,1.34 μg/mL,respectively;RSDs of precision,stability and reproducibility tests were lower than 3%;the recoveries of impurity A,B,C and D were 97.9%-103.1%(RSD=2.01%,n=9),98.8%-104.1%(RSD=1.93%,n=9),98.0%-103.6%(RSD=1.81%,n=9),100.8%-104.1%(RSD=0.98%,n=9),respectively. CONCLU-SIONS:The method is simple and accurate,and can be used for the determination of related substances in Vildagliptin tablets.
ABSTRACT
Angiogenesis is the process of capillary formation from the existing blood vessels, which is regulated by many cytokines.Balance of these cytokines plays an important role in angiogenesis.Unbalance of these cytokines, lead-ing to excessive or insufficient blood vessel, relates to a variety of diseases, such as tumor, ophthalmic diseases and wound healing.Recently, it has been observed that angiogenesis is also involved in Parkinson’s disease and Alzheimer’s disease. This review mainly discusses the molecular mechanism of angiogenesis and related diseases, and emphasizes the value of targeting angiogenesis as a strategy to develop drugs for those diseases.
ABSTRACT
Objective:To establish a method for the determination of the related substances in ticagrelor tablets. Methods:An op-timal HPLC method was set up and a Hypersil BDS C18 column (200 mm × 4. 6 mm, 5μm) was adopted. The mobile phase A was wa-ter (pH was adjusted to 3. 0 by phosphoric acid) and the mobile phase B was acetonitrile with gradient elution at a flow rate of 1. 0 ml ·min-1 , and the detection wavelength was set at 255 nm. The column temperature was 30 ℃, and the volume of injection was 5 μl. Results:The resolutions between ticagrelor and the adjacent impurity ( impurity E) , and between ticagrelor and the known impurities were all greater than 1. 5. Impurity A-H all had a good linear relationship within the range of 2. 0-20. 0 μg·ml-1(r>0. 996 0). The average recovery was 99. 8%, 98. 1%, 96. 5%, 101. 2%, 99. 3%, 100. 7%, 102. 1% and 103. 4% with RSD of 1. 02%, 0. 88%, 1. 13%, 0. 56%, 0. 79%, 1. 11%, 0. 63% and 1. 39%, respectively(n=9). Conclusion:The method is reproducible and accurate in the determination of the related substances in ticagrelor tables.
