ABSTRACT
Metastases to the breast from extramammary neoplasms are very rare. Correct diagnosis of breast malignancy is important for establishing appropriate management and for avoiding unnecessary radical surgery. Metastasized breast malignancies from non-small cell lung carcinoma are extremely rare. Here we report a 55-year old female patient with breast metastasis from lung adenocarcinoma which was diagnosed with fine needle aspiration cytology and confirmed by immunocytochemistry.
Subject(s)
Adenocarcinoma/secondary , Biopsy, Fine-Needle , Breast Neoplasms/secondary , Lung Neoplasms/pathology , Adenocarcinoma/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Diagnosis, Differential , Female , Humans , Lung Neoplasms/diagnostic imaging , Middle Aged , RadiographyABSTRACT
We report a case of synchronous bilateral breast cancer with ductal and medullary carcinoma. A 60-year-old woman presented with lesion in both breasts which were mammographically found two years ago. Ultrasonography proved two suspected masses in breasts. Fine needle cytology was performed and confirmed bilateral carcinoma but with different cytological findings. The cytological feature of the left breast suggested ductal carcinoma and of the right breast raised possibility of a medullary carcinoma. Patient underwent bilateral quadrectomy with evacuation of axillary lymph nodes. Histological examination showed bilateral carcinoma with two different histological features: ductal in the left and medullary carcinoma in the right breast.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal/pathology , Carcinoma, Medullary/pathology , Biopsy, Fine-Needle , Breast Neoplasms/diagnostic imaging , Breast Neoplasms/surgery , Carcinoma, Ductal/surgery , Carcinoma, Medullary/surgery , Cell Nucleus/pathology , Female , Humans , Lymphatic Metastasis , Lymphocytes/pathology , Middle Aged , Plasma Cells/pathology , UltrasonographyABSTRACT
BACKGROUND: In this study, we describe the prognostic value of NSCLC morphologic characteristics obtainable by computed tomography (CT) in the preoperative staging. Starting with the initial hypothesis that CT morphologic characteristics of NSCLC have a prognostic value, we conducted a retrospective study that included 194 patients. PATIENTS AND METHODS: All patients underwent surgery because of stage IA or IB non-small-cell lung carcinoma (NSCLC). Surgical procedures were performed in our clinic over the period of 9 years and 8 months starting in June 1996 and ending in February 2006. Preoperative CT scans and clinical data available for each patient were analyzed retrospectively. RESULTS: Over the study period, 93 patients died. The mean survival time was 78.6 months (95% confidence interval was 72.63-84.57 months). After a 2-year follow-up, 85.57% of patients were alive, but this decreased to 63.9% living patients after 5 years. Morphologic tumor characteristics were obtained by analyzing CT images available for each patient. These CT morphologic characteristics were divided into 5 categories: size, tumor edges, structure, and periphery of the tumor, as well as its relation to visceral pleura. We correlated each of these characteristics to the survival of patients. CONCLUSION: We conclude that, within stage I NSCLC, patient survival and disease prognosis vary significantly depending on such morphologic characteristics. This fact is one of the weakest points of the current tumor-node-metastasis (TNM) classification. Along with already-established tumor prognostic attributes such as size and TNM grade, we identified CT morphologic characteristics as powerful additional prognostic factors for NSCLC.
