ABSTRACT
The authors determined beta 2 microglobulin plasmatic and urinary levels in 35 children aged 1 month-14 years; 25 of them were suffering from reflux nephropathy. The results of this study indicate that B2 microglobulin concentrations in plasma and urine can be useful parameters to the clinical diagnosis and evaluation of severity of reflux nephropathy. In presence of reduced glomerular filtration rate B2 microglobulin plasmatic levels resulted significantly out of the normal range (mean = 3318; s.d. = 1184) and proportional to the residual functionality degree (p 0.005); blood B2 microglobulin values demonstrated a higher specificity (76.2%) than creatine clearance. Moreover Bt (B2 microglobulin urinary level), Bs (B2 microglobulin excretion per minute corrected to surface area) and Bf (B- microglobulin excretory fraction) were shown to vary (p 0.025) in relation to the presence and the degree of tubulo-interstitial damage. In particular, Bf values progressively impairing with the severity of the nephropathy, were shown to have a statistically good distribution and the best sensibility (95.2%) and specificity (77.8%) in detecting tubular damage.
Subject(s)
Kidney Diseases/etiology , Vesico-Ureteral Reflux/diagnosis , beta 2-Microglobulin/analysis , Adolescent , Analysis of Variance , Child , Child, Preschool , Glomerular Filtration Rate , Humans , Infant , Kidney Diseases/blood , Kidney Diseases/urine , Vesico-Ureteral Reflux/blood , Vesico-Ureteral Reflux/complications , Vesico-Ureteral Reflux/urine , beta 2-Microglobulin/urineSubject(s)
Abnormalities, Multiple/epidemiology , Urinary Tract/abnormalities , Birth Weight , Clinical Trials as Topic , Female , Humans , Infant, Newborn , Italy , MaleABSTRACT
The authors evaluated some renal functional parameters of 23 children, the ages ranged 1 to 58 weeks; 8 were affected with cyanotic congenital heart disease and 15 with acyanotic forms. They showed the presence, already in this age, of some affections that are quiet similar to those affecting older children with heart disease. They tried to explain the renal functional deficiency in consideration of the literature data also. The authors formed a functional deficiency greater in the cyanotic forms, proportional to the weight deficiency and the same as that described in dystrophic children. They think that this is due to a first year maturational retardation, because of a low trophism of the body, in particular of the kidney. The authors suggest that these patients have to be fed with appropriate caloric-protein diet.
