1.
J Med Chem
; 27(7): 870-4, 1984 Jul.
Article
in English
| MEDLINE
| ID: mdl-6737430
ABSTRACT
The in vivo antitumor activity and in vitro metabolic dealkylation have been measured for an homologous series of 3-alkyl-1-(4-carbamoylphenyl)-3-methyltriazenes and have been compared with their partition coefficients. This investigation has shown that the extent of oxidative metabolism in vitro and the antitumor activity in vivo of these compounds are dependent upon hydrophobicity. These findings provide confirmation for the relationship between metabolism and antitumor activity for aryldialkyltriazenes.
Subject(s)
Antineoplastic Agents/chemical synthesis , Triazenes/chemical synthesis , Animals , Chromatography, High Pressure Liquid , Female , Lymphoma/drug therapy , Mathematics , Mice , Mice, Inbred CBA , Microsomes, Liver/metabolism , Structure-Activity Relationship , Triazenes/therapeutic use
2.
Biochem Pharmacol
; 25(3): 241-6, 1976 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-1267820
Subject(s)
Antineoplastic Agents/therapeutic use , Triazenes/therapeutic use , Animals , Chemical Phenomena , Chemistry , Dealkylation , Female , Half-Life , Lymphoma/drug therapy , Mice , Mice, Inbred CBA , Neoplasms, Experimental/drug therapy , Structure-Activity Relationship , Triazenes/metabolism
3.
Cancer Res
; 34(2): 275-80, 1974 Feb.
Article
in English
| MEDLINE
| ID: mdl-4855748
Subject(s)
Alkylating Agents/pharmacology , Azirines/pharmacology , Carcinoma 256, Walker , DNA, Neoplasm/biosynthesis , Neoplasm Proteins/biosynthesis , Purines/biosynthesis , RNA, Neoplasm/biosynthesis , Animals , Benzamides/pharmacology , Cell Line , Depression, Chemical , Melphalan/pharmacology , Mice , Nitro Compounds/pharmacology , Purines/metabolism , Rats , Thymidine/metabolism , Time Factors , Tritium , Uridine/metabolism
4.
Biochem Pharmacol
; 22(15): 1855-64, 1973 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-4722457
