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1.
Neurosurgery ; 87(2): 247-255, 2020 08 01.
Article in English | MEDLINE | ID: mdl-31584074

ABSTRACT

BACKGROUND: There are presently no grading scales that specifically address the outcomes of cranial dural arteriovenous fistula (dAVF) after stereotactic radiosurgery (SRS). OBJECTIVE: To design a practical grading system that would predict outcomes after SRS for cranial dAVFs. METHODS: From the International Radiosurgery Research Foundation (University of Pittsburgh [41 patients], University of Pennsylvania [6 patients], University of Sherbrooke [2 patients], University of Manitoba [1 patient], West Virginia University [2 patients], University of Puerto Rico [1 patient], Beaumont Health System 1 [patient], Na Homolce Hospital [13 patients], the University of Virginia [48 patients], and Yale University [6 patients]) centers, 120 patients with dAVF treated with SRS were included in the study. The factors predicting favorable outcome (obliteration without post-SRS hemorrhage) after SRS were assessed using logistic regression analysis. These factors were pooled with the factors that were found to be predictive of obliteration from 7 studies with 736 patients after a systematic review of literature. These were entered into stepwise multiple regression and the best-fit model was identified. RESULTS: Based on the predictive model, 3 factors emerged to develop an SRS scoring system: cortical venous reflux (CVR), prior intracerebral hemorrhage (ICH), and noncavernous sinus location. Class I (score of 0-1 points) predicted the best favorable outcome of 80%. Class II patients (2 points score) had an intermediate favorable outcome of 57%, and class III (score 3 points) had the least favorable outcome at 37%. The ROC analysis showed better predictability to prevailing grading systems (AUC = 0.69; P = .04). Kaplan-Meier analysis showed statistically significant difference between the 3 subclasses of the proposed grading system for post-SRS dAVF obliteration (P = .001). CONCLUSION: The proposed dAVF grading system incorporates angiographic, anatomic, and clinical parameters and improves the prediction of the outcomes following SRS for dAVF as compared to the existing scoring systems.


Subject(s)
Central Nervous System Vascular Malformations/pathology , Central Nervous System Vascular Malformations/surgery , Radiosurgery , Treatment Outcome , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Prognosis , ROC Curve , Retrospective Studies , Risk Factors , Young Adult
2.
World Neurosurg ; 125: e1114-e1124, 2019 05.
Article in English | MEDLINE | ID: mdl-30790731

ABSTRACT

OBJECTIVE: This study aims to evaluate the outcomes of Gamma Knife stereotactic radiosurgery (SRS) for dural arteriovenous fistulas (dAVFs) in older patients (≥65 years) compared with younger patients (age <65 years). METHODS: Two groups with a total of 96 patients were selected from a database of 133 patients with dAVF from 9 international medical centers with a minimum 6 months follow-up. A 1:2 propensity matching was performed by nearest-neighbor matching criteria based on sex, Borden grade, maximum radiation dose given, and location. The older cohort consisted of 32 patients and the younger cohort consisted of 64 patients. The mean overall follow-up in the combined cohort was 42.4 months (range, 6-210 months). RESULTS: In the older cohort, a transverse sinus location was found to significantly predict dAVF obliteration (P = 0.01). The post-SRS actuarial 3-year and 5-year obliteration rates were 47.7% and 78%, respectively. There were no cases of post-SRS hemorrhage. In the younger cohort, the cavernous sinus location was found to significantly predict obliteration (P = 0.005). The 3-year and 5-year actuarial obliteration rates were 56% and 70%, respectively. Five patients (7.8%) hemorrhaged after SRS. Margin dose ≥25 Gy was predictive of unfavorable outcome. The obliteration rate (P = 0.3), post-SRS hemorrhage rate (P = 0.16), and persistent symptoms after SRS (P = 0.83) were not statistically different between the 2 groups. CONCLUSIONS: SRS achieves obliteration in most older patients with dAVF, with an acceptable rate of complication. There was no increased risk of postradiosurgery complications in the older cohort compared with the younger patients.


Subject(s)
Central Nervous System Vascular Malformations/epidemiology , Central Nervous System Vascular Malformations/radiotherapy , Radiosurgery , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Cavernous Sinus/abnormalities , Cavernous Sinus/radiation effects , Child , Cohort Studies , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Propensity Score , Transverse Sinuses/abnormalities , Transverse Sinuses/radiation effects , Treatment Outcome , Young Adult
3.
Am J Otolaryngol ; 35(3): 449-51, 2014.
Article in English | MEDLINE | ID: mdl-24457128

ABSTRACT

Congenital arteriovenous fistulas (AVFs) result from inadequate differentiation of the vascular system during fetal development. This case report describes an AVF of the neck, which possibly manifested as noise interference during a newborn hearing-screening test by otoacoustic emissions (OAEs). This report is in compliance with the institutional review board regulations of the University of Puerto Rico School of Medicine.


Subject(s)
Arteriovenous Fistula/diagnosis , Hearing Tests , Neck/blood supply , Neonatal Screening , Female , Humans , Infant , Infant, Newborn
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