Optimizing the random search of a finite-lived target by a Lévy flight.

In many random search processes of interest in chemistry, biology, or during rescue operations, an entity must find a specific target site before the latter becomes inactive, no longer available for reaction or lost. We present exact results on a minimal model system, a one-dimensional searcher performing a discrete time random walk, or Lévy flight. In contrast with the case of a permanent target, the capture probability and the conditional mean first passage time can be optimized. The optimal Lévy index takes a nontrivial value, even in the long lifetime limit, and exhibits an abrupt transition as the initial distance to the target is varied. Depending on the target lifetime, this transition is discontinuous or continuous, separated by a nonconventional tricritical point. These results pave the way to the optimization of search processes under time constraints.

First hitting times between a run-and-tumble particle and a stochastically gated target.

We study the statistics of the first hitting time between a one-dimensional run-and-tumble particle and a target site that switches intermittently between visible and invisible phases. The two-state dynamics of the target is independent of the motion of the particle, which can be absorbed by the target only in its visible phase. We obtain the mean first hitting time when the motion takes place in a finite domain with reflecting boundaries. Considering the turning rate of the particle as a tuning parameter, we find that ballistic motion represents the best strategy to minimize the mean first hitting time. However, the relative fluctuations of the first hitting time are large and exhibit nonmonotonous behaviors with respect to the turning rate or the target transition rates. Paradoxically, these fluctuations can be the largest for targets that are visible most of the time, and not for those that are mostly invisible or rapidly transiting between the two states. On the infinite line, the classical asymptotic behavior ∝t^{-3/2} of the first hitting time distribution is typically preceded, due to target intermittency, by an intermediate scaling regime varying as t^{-1/2}. The extent of this transient regime becomes very long when the target is most of the time invisible, especially at low turning rates. In both finite and infinite geometries, we draw analogies with partial absorption problems.

First Hitting Times to Intermittent Targets.

In noisy environments such as the cell, many processes involve target sites that are often hidden or inactive, and thus not always available for reaction with diffusing entities. To understand reaction kinetics in these situations, we study the first hitting time statistics of a one-dimensional Brownian particle searching for a target site that switches stochastically between visible and hidden phases. At high crypticity, an unexpected rate limited power-law regime emerges for the first hitting time density, which markedly differs from the classic t^{-3/2} scaling for steady targets. Our problem admits an asymptotic mapping onto a mixed, or Robin, boundary condition. Similar results are obtained with non-Markov targets and particles diffusing anomalously.