1.
J Org Chem
; 66(15): 5058-65, 2001 Jul 27.
Article
in English
| MEDLINE
| ID: mdl-11463257
ABSTRACT
Two novel 5(20)-thia analogues of docetaxel have been synthesized from 10-deacetylbaccatin III or taxine B and isotaxine B. The key step of these syntheses is the concomitant thietane ring formation and acetylation of the tertiary alcohol at C-4. Both compounds are less cytotoxic than docetaxel but have divergent activity on microtubule disassembly.