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J Pharm Sci ; 98(5): 1845-51, 2009 May.
Article in English | MEDLINE | ID: mdl-18781632

ABSTRACT

The influence of the ageing process on the low frequency behavior of some electrical parameters of naphazoline hydrochloride solutions at 0.5% and 1% in concentration and of 2% paracetamol syrup, is studied. The impedance measurements were performed, in the range between 200 Hz and 1 MHz, using an impedance analyzer and a cell for liquids with plane parallel electrodes whose separation can be changed by using a set of spacers, provided by the manufacturer, in order to get better control of the influence of electrodes polarization effect. The ageing state was artificially generated by dilution and/or heating separated procedures. The results show that this dielectric technique can be used as a good quality complementary control technique.


Subject(s)
Acetaminophen/chemistry , Analgesics, Non-Narcotic/chemistry , Naphazoline/chemistry , Nasal Decongestants/chemistry , Acetaminophen/administration & dosage , Administration, Intranasal , Algorithms , Analgesics, Non-Narcotic/administration & dosage , Drug Combinations , Electric Impedance , Electrodes , Naphazoline/administration & dosage , Nasal Decongestants/administration & dosage , Pharmaceutical Solutions , Suspensions
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