ABSTRACT
A case of acute dissecting aneurysm of the aorta in a seriously hypertensive woman was treated for 9 days with continuously infused labetalol hydrochloride, initially at 1 mg/min and later at 125 mg/min. Continuous, invasive monitoring of arterial pressure showed values to be within present safety limits, even though the treatment was first supplemented with furosemide and then with clonidine. The use of labetalol in hypertension emergencies offers and alternative to the employment of dangerous drugs that have a transient effect, or are even unadvisable for treatments lasting longer than two days.
Subject(s)
Ethanolamines/administration & dosage , Hypertension/drug therapy , Labetalol/administration & dosage , Aortic Dissection/drug therapy , Aorta, Thoracic , Aortic Aneurysm/drug therapy , Electrocardiography , Emergencies , Female , Humans , Infusions, Parenteral , Middle AgedABSTRACT
After recalling the specific problems of anaesthesia in ORL and the pharmacological features of Althesin, a personal series is reported. The individual problems arising from the various types of intervention considered are analysed and it is concluded that the advantages deriving from the new steroid are general and specific and are seen not only during operation but in the post-operative period where they influence the course and reduce complications.
Subject(s)
Alfaxalone Alfadolone Mixture , Otorhinolaryngologic Diseases/surgery , Adolescent , Adult , Aged , Anesthesia, Intravenous/methods , Child , Child, Preschool , Drug Evaluation , Humans , Ketamine , Middle AgedABSTRACT
As part of a study on i.v. drugs that have recently entered clinical practice, the association of a hypnotic, althesin and an analgesic, ketamine is reproposed. To boost the respective pharmacological actions, the low doses employed revealed none of the negative effects attributable to the drugs taken singly, while anaesthesiological treatment was quite satisfactory.
Subject(s)
Alfaxalone Alfadolone Mixture , Anesthesia, Intravenous/methods , Ketamine , Surgical Procedures, Operative , Adolescent , Adult , Aged , Child , Drug Evaluation , Drug Tolerance , Humans , Middle Aged , Preanesthetic MedicationABSTRACT
Accidents during anaesthesia may be clinical or technical. To avoid the latter, stress is laid on the by no means new concept that techniques and handling must fit contingent requirements and that they may be dangerous as much for their inadequate as for their excessive use.
Subject(s)
Anesthesia, General/adverse effects , Iatrogenic Disease , Humans , Intubation, Intratracheal/adverse effectsABSTRACT
The activity of a drug is completely defined by experimentation and the results of clinical experiments. Specifically, the use of anaesthetic drugs in cardiopaths must meet certain requirements: no toxicity, no rises in cardiac rhythm. A slight hypotensive action can be tolerated because this is not related to cardiac hypoxia and thus places the myocardium in a more favourable situation.
