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4.
Br Med J ; 2(5916): 409-12, 1974 May 25.
Article in English | MEDLINE | ID: mdl-4135071

ABSTRACT

Clinical, immunological, and histological recovery in a patient with alpha-chain disease is described. The patient, a 27-year-old Greek man, presented with severe steatorrhoea, abdominal pain, oedema, and hypogammaglobulinaemia. Treatment with tetracycline produced only temporary remission. Intermittent therapy with prednisone and cyclophosphamide together with antibiotics was followed by clinical recovery, return of histological appearances of the small intestine to normal, and disappearance of free alpha-chain protein from the serum. The patient remained well one year later without treatment.


Subject(s)
Cyclophosphamide/therapeutic use , Immunoglobulin A/analysis , Prednisone/therapeutic use , Tetracycline/therapeutic use , Adult , Beta-Globulins/analysis , Biopsy , Celiac Disease/immunology , Celiac Disease/pathology , Diet Therapy , Fluorescent Antibody Technique , Glucose Tolerance Test , Glutens , Heavy Chain Disease/drug therapy , Heavy Chain Disease/immunology , Heavy Chain Disease/pathology , Humans , Immunoelectrophoresis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Intestinal Absorption , Intestinal Mucosa/pathology , Jejunum/pathology , Male , T-Lymphocytes/immunology , Xylose
7.
Lancet ; 1(7655): 1057-8, 1970 May 16.
Article in English | MEDLINE | ID: mdl-4191660
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