Search | VHL Regional Portal

Relationship between hepatic levels of glutathione and sulphobromophthalein retention in hyperthyroidism.

Sir, T; Wolff, C; Soto, J R; Perez, G; Merino, R A.

Clin Sci (Lond) ; 73(2): 235-7, 1987 Aug.

Article in English | MEDLINE | ID: mdl-3652628

ABSTRACT

1. Sulphobromophthalein (BSP) retention and liver glutathione levels were studied in uncomplicated hyperthyroid patients. 2. BSP retention was increased in 52.5% of the subjects at admission (n = 40) and in 28% of the cases after 3 months of propylthiouracil treatment (300-400 mg/day) (n = 25). 3. Hepatic levels of glutathione were measured in six patients and significant inversed power correlation with BSP retention was observed (r = 0.968, P less than 0.001). 4. These data support the contention that the alteration of the BSP retention observed in hyperthyroidism could be due to a decreased availability of hepatic glutathione for conjugation.

Subject(s)

Glutathione/metabolism , Hyperthyroidism/metabolism , Liver/metabolism , Sulfobromophthalein/metabolism , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged

Vigilancia de efectos adversos sobre el higado de una combinacion de drogas antituberculosas. / Surveillance of adverse effects of antituberculous therapy upon the liver

Estay, S; Merino, R. A; Busel, I; Baier, E; Wolff, C; Jabsa, Z.

Rev. méd. Chile ; 109(3): 212-20, 1981.

Article in Spanish | LILACS | ID: lil-2732

Subject(s)

Antitubercular Agents , Liver , Tuberculosis, Pulmonary

[Phlebotomy in porphyria cutanea tarda (author's transl)]. / Flebotomía en el tratamiento de las manifestaciones cutáneas de la porfiria variegata.

Merino, R A; Wolff, C.

Rev Med Chil ; 107(9): 838-41, 1979 Sep.

Article in Spanish | MEDLINE | ID: mdl-542750

Subject(s)

Bloodletting , Porphyrias/surgery , Skin Diseases/surgery , Adult , Coproporphyrins/urine , Female , Ferrochelatase/biosynthesis , Follow-Up Studies , Humans , Male , Middle Aged , Porphyrias/enzymology , Porphyrins/urine

[Critical analysis of bilirubinemia and diagnostic value of direct bilirubin determination by the Malloy-Evelyn method]. / Análisis crítico de la determinación de la bilirrubinemia y del valor diagnóstico de la bilirrubina directa por el metodo de Malloy y Evelyn.

Merino, R A; Lalive, J; Parga, G L.

Rev Med Chil ; 96(12): 794-8, 1968 Dec.

Article in Spanish | MEDLINE | ID: mdl-5732520

Subject(s)

Hyperbilirubinemia/diagnosis , Bilirubin/blood , Chromatography, Paper , Humans , Methods , Time Factors

ABSTRACT

Subject(s)

Subject(s)

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL