ABSTRACT
El hierro es un elemento químico esencial para todos los organismos vivos, necesario para un amplio espectro de funciones metabólicas vitales. La exploración del metabolismo del hierro puede ser difícil en algunas situaciones, tales como en el paciente con una enfermedad crónica, por la respuesta de los biomarcadores frente a la inflamación. En los últimos años el laboratorio clínico ha incorporado nuevos biomarcadores a los tradicionalmente empleados, con el fin de mejorar su contribución al diagnóstico y seguimiento de la ferropenia. Se ha realizado una búsqueda sistemática de la evidencia científica publicada en los diez últimos años para los siguientes biomarcadores: el diagnóstico morfológico de la sangre periférica, los índices hematimétricos, y las concentraciones plasmáticas de transferrina (y sus índices), ferritina, receptor soluble de transferrina y hemoglobina, en la ferropenia. Se emiten recomendaciones para estos biomarcadores en relación al diagnóstico y manejo del paciente ferropénico
Iron is an essential chemical element for all living organisms, and is required for a broad spectrum of vital metabolic functions. The study of iron metabolism can be challenging in some situations, such as in patients with chronic diseases, due to the effect of inflammation response. In recent years, clinical laboratory research has introduced new biomarkers to those commonly used, with the aim of improving the diagnosis and management of iron deficiency. In this work, a systematic search of the scientific evidence reported during the last decade has been made for the following biomarkers: morphological diagnosis of peripheral blood, hematimetric indices, and plasma concentrations of transferrin (and its indices), ferritin, transferrin receptor, and haemoglobin, in iron deficiency. Recommendations are made for these biomarkers related to the diagnosis and management of the iron-deficient patient
Subject(s)
Humans , Anemia, Iron-Deficiency/diagnosis , 16595/diagnosis , Iron Metabolism Disorders/diagnosis , Ferritins/blood , Reticulocyte Count/methods , Erythrocyte Indices , Transferrins/blood , Hemoglobinometry/methods , Guidelines as Topic , Clinical Laboratory Techniques/methods , Biomarkers/analysis , Renal Insufficiency, Chronic/complications , Hematologic Tests/methodsABSTRACT
OBJECTIVE: To determine the degree of correlation between the clinical diagnosis prior to the minor surgery process and its concordance with the results of histopathology report, as well as to determine the surgical data of little clinical importance compared to that which is really necessary and cost-effective. MATERIAL AND METHOD: A descriptive, observational, retrospective and transversal study was conducted of the Minor Surgery Activities of a clinic in the Ciudad Real Health Centre I. RESULTS: A total of 124 surgical specimens were sent for clinical diagnostic comparison, of which, the main clinical diagnoses were: intradermal melanocytic nevi (34.67%), seborrheic keratosis (11.30%), and epidermoid or sebaceous cysts (10.48%). A correlation of 68% was obtained. The protocols of the work centre have been followed to carry out this study in relation to the confidentiality of the data. CONCLUSIONS: These results were analysed and compared with other similar works performed in the field of minor surgery in Primary Care, being able to affirm that there is a good correlation between the initial clinical diagnosis and the histopathology results.
