ABSTRACT
No disponible
Subject(s)
Humans , Male , Child, Preschool , Pneumocystis carinii/virology , Respiratory Insufficiency/therapy , Coronavirus Infections/diagnostic imaging , Coronavirus Infections/drug therapy , Betacoronavirus/drug effects , Pneumonia, Viral/diagnostic imaging , Pneumonia, Viral/drug therapy , Leukemia, Biphenotypic, Acute/drug therapy , Pancytopenia/complications , Amphotericin B/administration & dosage , Radiography, Thoracic , Polymerase Chain Reaction , Azithromycin/administration & dosage , Hydroxychloroquine/administration & dosage , Lopinavir/administration & dosage , Respiratory Insufficiency/diagnostic imaging , Oxygen Inhalation TherapyABSTRACT
No disponible
Subject(s)
Humans , Coronavirus Infections/drug therapy , Severe acute respiratory syndrome-related coronavirus/pathogenicity , Lopinavir/pharmacokinetics , Ritonavir/pharmacokinetics , Acute Chest Syndrome/drug therapy , Darunavir/pharmacokinetics , Cobicistat/pharmacokinetics , Decision Making , Policy Making , Pandemics/prevention & controlABSTRACT
The objective of this study was to assess the effectiveness of a catheter-related bloodstream infection (CR BSI) reduction programme and healthcare workers' compliance with recommendations. A 3-year surveillance programme of CR BSIs in all hospital settings was implemented. As part of the programme, there was a direct observation of insertion and maintenance of central venous catheters (CVCs) to determine performance. A total of 38 education courses were held over the study period and feedback reports with the results of surveillance and recommendations were delivered to healthcare workers every 6 months. A total of 6722 short-term CVCs were inserted in 4982 patients for 58 763 catheter-days. Improvements of compliance with hand hygiene was verified at the insertion (87·1-100%, P < 0·001) and maintenance (51·1-72·1%, P = 0·029) of CVCs; and the use of chlorhexidine for skin disinfection was implemented at insertion (35·7-65·4%, P < 0·001) and maintenance (33·3-45·9%, P < 0·197) of CVCs. There were 266 CR BSI incidents recorded with an annual incidence density of 5·75/1000 catheter-days in the first year, 4·38 in the second year [rate ratio (RR) 0·76, 95% confidence interval (CI) 0·57-1·01] and 3·46 in the third year (RR 0·60, 95% CI 0·44-0·81). The education programme clearly improved compliance with recommendations for CVC handling, and was effective in reducing the burden of CR BSIs.
Subject(s)
Catheter-Related Infections/epidemiology , Catheter-Related Infections/prevention & control , Health Services Research , Infection Control/methods , Sepsis/epidemiology , Sepsis/prevention & control , Adult , Aged , Attitude of Health Personnel , Catheterization/adverse effects , Central Venous Catheters/adverse effects , Disinfection/methods , Disinfection/statistics & numerical data , Education, Medical , Female , Guideline Adherence , Humans , Incidence , Male , Middle Aged , Tertiary Care CentersABSTRACT
The aggressive clinical course of pneumococcal endocarditis. A retrospective study was conducted between 2000 and 2005 in five patients with pneumococcal endocarditis were diagnosed at our center. Three female and 2 males, 13 to 76 year-old, were attended. Most of them had left valve endocarditis and were suffering from predisposing conditions. All of them developed distant complications as embolism or septic metastases. Two patients were successfully operated. Surgery was considered in another one but it was discarded due to her poor general condition. This was the only death in the series.
Subject(s)
Endocarditis, Bacterial , Pneumococcal Infections , Adolescent , Adult , Aged , Endocarditis, Bacterial/complications , Endocarditis, Bacterial/diagnosis , Endocarditis, Bacterial/surgery , Fatal Outcome , Female , Humans , Male , Middle Aged , Pneumococcal Infections/complications , Pneumococcal Infections/diagnosis , Pneumococcal Infections/surgery , Retrospective StudiesABSTRACT
Realizamos un estudio retrospectivo de cinco casos diagnosticados de endocarditis neumocócica en nuestro hospital entre 2000 y 2005. Se trata de tres mujeres y dos varones con edades entre 13 y 76 años. La mayoría tuvieron afectadas las válvulas izquierdas y presentaron enfermedades predisponentes. Todos los pacientes presentaron enfermedad neumocócica a distancia en forma de embolismo o metástasis séptica. En dos pacientes se llevó a cabo cirugía cardíaca con éxito y en otro se desestimó por la mala situación clínica, siendo el único caso que falleció (AU)
A retrospective study was conducted between 2000 and 2005 in five patients with pneumococcal endocarditis were diagnosed at our center. Three female and 2 males, 13 to 76 year-old, were attended. Most of them had left valve endocarditis and were suffering from predisposing conditions. All of them developed distant complications as embolism or septic metastases. Two patients were successfully operated. Surgery was considered in another one but it was discarded due to her poor general condition. This was the only death in the series (AU)
