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1.
J Pediatr ; 233: 283-284, 2021 06.
Article in English | MEDLINE | ID: mdl-33631168
2.
Eur J Clin Microbiol Infect Dis ; 36(2): 295-303, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27718071

ABSTRACT

The objective of this study was to evaluate the efficacy and safety of fidaxomicin in the real-life clinical setting. This was a retrospective cohort of patients with Clostridium difficile infection (CDI) treated with fidaxomicin in 20 Spanish hospitals between July 2013 and July 2014. Clinical cure, 30-day recurrence, 30-day mortality, sustained cure, and factors associated with the failure to achieve sustained cure were analyzed. Of the 72 patients in the cohort 41 (56.9 %) had a fatal underlying disease. There were 44 (61.1 %) recurrent episodes and 26 cases (36.1 %) with a history of multiple recurrences. Most episodes were severe (26, 36 %) or severe-complicated (14, 19.4 %). Clinical cure rate was 90.3 %, recurrence rate was 16.7 % and three patients (4.2 %) died during the follow-up period. Sustained cure was achieved in 52 cases (72.2 %). Adverse events were reported in five cases (6.9 %). Factors associated with the lack of sustained cure were cardiovascular comorbidity (OR 11.4; 95 %CI 1.9-67.8), acute kidney failure (OR 7.4; 95 %CI 1.3-43.1), concomitant systemic antibiotic treatment (OR 6.2; 95 %CI 1.1-36.8), and C-reactive protein value at diagnosis (OR 1.2 for each 1 mg/dl increase; 95 %CI 1.03-1.3). Fidaxomicin is an effective and well tolerable treatment for severe CDI and for cases with elevated recurrence risk.


Subject(s)
Aminoglycosides/therapeutic use , Anti-Bacterial Agents/therapeutic use , Clostridioides difficile/isolation & purification , Clostridium Infections/drug therapy , Diarrhea/drug therapy , Adolescent , Adult , Aged , Aged, 80 and over , Aminoglycosides/adverse effects , Anti-Bacterial Agents/adverse effects , Clostridioides difficile/drug effects , Clostridium Infections/microbiology , Diarrhea/microbiology , Drug-Related Side Effects and Adverse Reactions , Fidaxomicin , Hospitals , Humans , Male , Middle Aged , Retrospective Studies , Spain , Survival Analysis , Treatment Outcome , Young Adult
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