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Successful treatment of multidrug-resistant Pseudomonas aeruginosa breakthrough bacteremia with ceftolozane/tazobactam.

Hernández-Tejedor, Alberto; Merino-Vega, Carmen Débora; Martín-Vivas, Alfredo; Ruiz de Luna-González, Rafael; Delgado-Iribarren, Alberto; Gabán-Díez, Ángeles; Temprano-Gómez, Ignacio; de la Calle-Pedrosa, Natalia; González-Jiménez, Ana Isabel; Algora-Weber, Alejandro.

Infection ; 45(1): 115-117, 2017 Feb.

Article in English | MEDLINE | ID: mdl-27670678

ABSTRACT

INTRODUCTION: Ceftolozane/tazobactam is a novel antibiotic approved for the treatment of complicated intra-abdominal and complicated urinary tract infections. CASE DESCRIPTION: We describe the use of off-label ceftolozane/tazobactam in the management of a multidrug-resistant Pseudomonas aeruginosa bacteremia that was already being treated with colistin and amikacin, the only active antibiotics according to the antibiogram.

Subject(s)

Anti-Bacterial Agents/therapeutic use , Bacteremia , Cephalosporins/therapeutic use , Penicillanic Acid/analogs & derivatives , Pseudomonas Infections , Pseudomonas aeruginosa/drug effects , Anti-Bacterial Agents/pharmacology , Bacteremia/drug therapy , Bacteremia/epidemiology , Bacteremia/microbiology , Cephalosporins/pharmacology , Drug Resistance, Multiple, Bacterial , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Off-Label Use , Penicillanic Acid/pharmacology , Penicillanic Acid/therapeutic use , Pseudomonas Infections/drug therapy , Pseudomonas Infections/epidemiology , Pseudomonas Infections/microbiology , Tazobactam

ABSTRACT

Subject(s)

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