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[Bioequivalence of anvifen and phenibut].

Zhezlova, A V; Belolipetskaia, V G; Blagodatskikh, S V; Merkulova, E V.

Eksp Klin Farmakol ; 74(5): 43-4, 2011.

Article in Russian | MEDLINE | ID: mdl-21809698

ABSTRACT

An open randomized crossover test on 18 healthy volunteers was used to study the pharmacokinetics of anvifen (acting substance, aminophenylbutyric acid) manufactured in capsules at the Joint-Stock Company "Antiviral" (Russia). The test was performed after single peroral administration in comparison with phenibut tablets of the same manufacturer. The concentration of unchanged aminophenylbutiric acid in the blood plasma was measured by HPLC with UV detection. It is established that anvifen and phenibut are bioequivalent in terms of pharmacokinetics.

Subject(s)

Capsules/pharmacokinetics , Hypnotics and Sedatives/pharmacokinetics , Nootropic Agents/pharmacokinetics , Tablets/pharmacokinetics , gamma-Aminobutyric Acid/analogs & derivatives , Area Under Curve , Chromatography, High Pressure Liquid , Female , Humans , Male , Reference Standards , Russia , Sleep Wake Disorders/drug therapy , Therapeutic Equivalency , Young Adult , gamma-Aminobutyric Acid/pharmacokinetics

[Complications of prolonged peridural anesthesia in obstetric and gynecologic practice]. / Oslozhneniia dlitel'noi peridural'noi anestezii v akushersko-ginekologicheskoi klinike.

Manevich, L E; Kokhnover, S G; Merkulova, E V; Durova, A A.

Anesteziol Reanimatol ; (3): 59-61, 1986.

Article in Russian | MEDLINE | ID: mdl-3752615

Subject(s)

Anesthesia, Epidural/adverse effects , Anesthesia, Obstetrical/adverse effects , Female , Humans , Pregnancy

[Anesthesia during cesarean section]. / Anesteziia pri kesarevom sechenii.

Merkulova, E V; Durova, A A; Kokhnover, S G; Shchepatov, V V; Kolometskaia, A A.

Anesteziol Reanimatol ; (2): 65-7, 1985.

Article in Russian | MEDLINE | ID: mdl-4003843

Subject(s)

Anesthesia, Obstetrical/methods , Cesarean Section , Anesthesia, Epidural , Anesthesia, Local , Female , Hemodynamics/drug effects , Humans , Obstetric Labor Complications/physiopathology , Obstetric Labor Complications/surgery , Pregnancy

[Use of prolonged peridural anesthesia on parturients with heart defects]. / Primenenie dlitel'noi peridural'noi anestezii u rozhenits s porokami serdtsa

Merkulova, E V; Levashova, I I; Lisitsyna, N T; Manevich, L E; Durova, A A.

Vopr Okhr Materin Det ; 22(3): 75-9, 1977.

Article in Russian | MEDLINE | ID: mdl-867961

Subject(s)

Anesthesia, Epidural , Anesthesia, Obstetrical , Heart Diseases/therapy , Obstetric Labor Complications/therapy , Adult , Female , Hemodynamics/drug effects , Humans , Obstetric Labor Complications/physiopathology , Pregnancy , Rheumatic Heart Disease/therapy , Time Factors , Trimecaine

[Change of the renal function under the effect of anesthesia and surgery in gynecological patients]. / Izmeneniia funktsii pochek pod deistviem narkoza i operatsii u ginekologicheskikh bol'nykh

Merkulova, E V; Chistova, L K; Vlasova, L I; Krasnopol'skii, V I.

Akush Ginekol (Mosk) ; (8): 34-9, 1975 Aug.

Article in Russian | MEDLINE | ID: mdl-1200302

Subject(s)

Anesthesia, Inhalation , Genital Diseases, Female/surgery , Kidney/physiopathology , Female , Genital Diseases, Female/physiopathology , Genital Neoplasms, Female/physiopathology , Genital Neoplasms, Female/surgery , Humans , Kidney Function Tests

[Changes of kidney function in gynecological patients depending on the main and concomitant diseases]. / Izmeneniia funktsii pochek u ginekologicheskikh bol'nykh v zavisimosti ot osnovnogo i soputstvuiushchikh zabolevanii

Chistova, L K; Vlasova, L I; Merkulova, E V; Durova, A A.

Akush Ginekol (Mosk) ; 0(8): 40-3, 1974 Aug.

Article in Russian | MEDLINE | ID: mdl-4408836

Subject(s)

Endometriosis/physiopathology , Kidney/physiopathology , Leiomyoma/physiopathology , Ovarian Neoplasms/physiopathology , Uterine Neoplasms/physiopathology , Adult , Cardiovascular Diseases/complications , Female , Humans , Middle Aged , Ovarian Neoplasms/complications , Radioisotope Renography , Uterine Neoplasms/complications

[Hemodynamic changes during use of various types of combined anesthesia in gynecologic patients]. / Izmeneniia gemodinamika pri primenenii razlichnykh vidov kombinirovannoi anestezii u ginekologicheskikh bol'nykh.

Merkulova, E V; El'tsov-Strelkov, V I; Galkina, Z E; Titov, A A.

Akush Ginekol (Mosk) ; 49(1): 72-3, 1973 Jan.

Article in Russian | MEDLINE | ID: mdl-4696002

Subject(s)

Anesthesia, Endotracheal/adverse effects , Genital Diseases, Female/surgery , Adult , Female , Genital Diseases, Female/blood , Hemodynamics , Humans , Middle Aged , Neuroleptanalgesia/adverse effects

[Immediate and remote effects of Cesarean section on the infant under different methods of anesthesia]. / Blizhaishie i otdalennye rezul'taty kesareva secheniia dlia detei pri razlichnykh metodakh anestezii.

Zakharova, E S; Klimova, A A; Mastiukova, E M; Merkulova, E V.

Vopr Okhr Materin Det ; 17(4): 93-4, 1972 Apr.

Article in Russian | MEDLINE | ID: mdl-5081449

Subject(s)

Anesthesia, Obstetrical/adverse effects , Cesarean Section/adverse effects , Female , Humans , Infant, Newborn , Pregnancy

[Use of "controlled hypotension" for reducing hemorrhage in gynecologic surgery]. / Primenenie "upravliaemoi giptonii" slia umen'sheniia krovopoteri pri ginekologicheskikh operatsiiakh.

El'tsov-Strelkov, V I; Merkulova, E V.

Akush Ginekol (Mosk) ; 44(12): 27-32, 1968 Dec.

Article in Russian | MEDLINE | ID: mdl-4393570

Subject(s)

Genital Diseases, Female/surgery , Hemorrhage/prevention & control , Hypotension, Controlled , Female , Ganglionic Blockers , Humans , Methods

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