ABSTRACT
Perivascular epithelioïd cell tumor (PEComa) is a mesenchymal neoplasm with epithelioïd or spindled morphology with numerous thin-walled capillaries between tumor cells. They co-express markers of both melanocytic and smooth muscle differentiation. PEComas are rare, presenting in numerous anatomic sites including lung, kidney, liver, genitourinary tract, soft tissue, and skin. Primary cutaneous PEComas are very rare entity, and malignant ones are even more uncommon. Herein, we report the case of a 92-year-old female which was presenting with 7 cm exophytic, ulcerated, hemorrhagic nodular tumor, and rapidly growing for 8 months over the right thigh. On histologic examination, we found a dermal neoplasm formed by an atypical clear cell tumor with numerous branching capillaries between tumor cells. The mitotic count was found 6 mitotic figures/10 HPF. On immunohistochemistry, tumor cells co-expressed smooth muscle and melanocytic markers, CD10, and CD68. Based on these findings, the diagnosis of primary cutaneous malignant perivascular epithelioïd cell tumor (PEComa) was made. The large size (7 cm), the count of mitoses (6 mitotic figures/10 HPF), and the nuclear pleomorphism argued for malignancy. The absence of soft tissue or visceral localization argued for the cutaneous primitive origin. Adjuvant radiotherapy and targeted therapy with mTOR inhibitor (nab-sirolimus) was indicated. To the best of our knowledge, this is only the eighth case of a primary cutaneous malignant PEComa reported in the literature to date.
ABSTRACT
INTRODUCTION: Dermatoscopy is an innovative non-invasive technique for clinical morphology of pigmented lesions and skin tumor. The purpose of our study was to highlight the morphological and dermoscopic features of basal cell carcinoma (CBC) in our study population. METHODS: We conducted a prospective unicentric study over a period of 2 years. We used dermoscopy in all patients with BCC. Statistical analysis was performed using SPSS software version 17. RESULTS: The study included 100 patients with BCC, the average age of patients was 51.87 years, with a sex ratio F/M = 0.6. BCC most commonly occurred in the face and most patients were prototype III and IV. We established conventional and non-conventional dermatoscopic criteria. Our study showed that there is a significant relationship between prototype and the degree of BCC pigmentation. CONCLUSION: This study highlighted the key role of dermoscopy in detecting small-sized BCC and in facilitating the diagnosis of pigmented BCC.
Subject(s)
Carcinoma, Basal Cell/diagnosis , Dermoscopy/methods , Skin Neoplasms/diagnosis , Adult , Aged , Aged, 80 and over , Carcinoma, Basal Cell/pathology , Female , Humans , Male , Middle Aged , Morocco , Pigmentation , Prospective Studies , Skin Neoplasms/pathology , Young AdultABSTRACT
Introduction: la dermatoscopie est une technique d'examen non invasive, permettant de donner un nouveau regard de la morphologie clinique des lésions pigmentées et des tumeurs cutanées. Nous montrons à travers notre série les caractéristiques morphologiques dermotoscopiques du carcinome basocellulaire (CBC) chez notre population.Méthodes: notre étude est une étude prospective unicentrique étalée sur une période de 2 ans. Nous avons utilisé le dermoscope chez tous les patients ayant un CBC. L'analyse statistique était réalisée à 'aide du logiciel SPSS version 17.Résultats: on avait recensé 100 CBC, L'âge moyen des patients était de 51,87 ans, avec un sex ratio F/H = 0,6. Le visage était la localisation la plus fréquente et la plupart des patients étaient de phototype III et IV. On a distingué des critères dermatoscopiques classiques et non classiques. On a montré qu'il existe une relation significative entre le phototype et le degré de la pigmentation des CBC. Conclusion: dans ce présent travail, le dermoscope était bénéfique d'une part pour détecter les CBC de petite taille, d'autre part pour faciliter le diagnostic des CBC pigmentés
Subject(s)
Carcinoma, Basal Cell , Carcinoma, Basal Cell/diagnosis , Dermoscopy , Morocco , Pigmentation DisordersSubject(s)
Skin Diseases/blood , Skin Diseases/pathology , Vitamin D Deficiency/blood , Vitamin D/analogs & derivatives , Adolescent , Adult , Age Factors , Aged , Analysis of Variance , Biomarkers/blood , Female , Humans , Incidence , Male , Middle Aged , Morocco/epidemiology , Retrospective Studies , Risk Assessment , Sensitivity and Specificity , Skin Diseases/epidemiology , Vitamin D/blood , Young AdultSubject(s)
Pain Insensitivity, Congenital/diagnosis , Adolescent , Consanguinity , Diagnosis, Differential , Foot Deformities, Acquired/etiology , Hand Deformities, Acquired/etiology , Hereditary Sensory and Autonomic Neuropathies/diagnosis , Humans , Intellectual Disability/genetics , Male , NAV1.7 Voltage-Gated Sodium Channel/genetics , Pain Insensitivity, Congenital/genetics , Self MutilationSubject(s)
Gout Suppressants/therapeutic use , Gout/pathology , Uric Acid/metabolism , Aged , Diagnosis, Differential , Gout/diagnosis , Gout/drug therapy , Humans , MaleSubject(s)
Pancreatitis/diagnosis , Skin Diseases, Vesiculobullous/diagnosis , Xanthomatosis/diagnosis , Acute Disease , Adult , Diagnosis, Differential , Female , Humans , Pancreatitis/complications , Pancreatitis/pathology , Severity of Illness Index , Skin Diseases, Vesiculobullous/etiology , Skin Diseases, Vesiculobullous/pathology , Xanthomatosis/etiology , Xanthomatosis/pathologySubject(s)
Basal Cell Nevus Syndrome/diagnosis , Adult , Basal Cell Nevus Syndrome/complications , Calcinosis/diagnosis , Calcinosis/etiology , Dental Fistula/diagnosis , Dental Fistula/etiology , Female , Humans , Mandibular Diseases/diagnosis , Mandibular Diseases/etiology , Scoliosis/diagnosis , Scoliosis/etiology , Spinal CordSubject(s)
Bowen's Disease/pathology , Skin Neoplasms/pathology , Skin Pigmentation , Humans , Male , Middle AgedSubject(s)
Pemphigus/diagnosis , Umbilicus/pathology , Adult , Female , Humans , Pelvis/pathology , Pemphigus/pathologyABSTRACT
Cutaneous leukocytoclastic vasculitis (CLV) is an inflammatory vascular disorder rarely reported to be associated with tuberculosis. The following report describes the case of a young man with multifocal tuberculosis revealed by CLV. Diagnosis was confirmed by the presence of tuberculoid granuloma with caseous necrosis on pleural and perianal biopsy, and a rapid improvement in anti-tuberculous quadritherapy. Although rarely seen, Mycobacterium tuberculosis should be considered as a potential cause of CLV.
ABSTRACT
Cutaneous tuberculosis is rare. Its occurrence in multifocal tuberculosis (MT) is uncommon and happens frequently in the context of immunosuppression. We report the case of MT with multiple cutaneous gummas and bone and lung involvement that occurred in an apparently immunocompetent patient.
