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J Surg Oncol ; 104(7): 792-7, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21547915

ABSTRACT

BACKGROUND AND OBJECTIVES: The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC. METHODS: Clinical data from all colon cancer patients admitted in 1993-2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series. RESULTS: In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05). CONCLUSIONS: The incidence of PC was higher in right-sided colon cancer and among women. PC patients were younger than non-PC patients, and PC was independently associated with TP53 mutation in the primary tumor.


Subject(s)
Carcinoma/epidemiology , Carcinoma/genetics , Colonic Neoplasms/pathology , Genes, p53/genetics , Mutation , Peritoneal Neoplasms/epidemiology , Peritoneal Neoplasms/genetics , Adult , Aged , Aged, 80 and over , Carcinoma/secondary , Case-Control Studies , Colonic Neoplasms/epidemiology , DNA Mutational Analysis , DNA, Neoplasm/analysis , Female , Humans , Incidence , Male , Middle Aged , Multivariate Analysis , Norway/epidemiology , Peritoneal Neoplasms/secondary , Prospective Studies , Sex Distribution
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