1.
Chem Biodivers
; 20(8): e202201158, 2023 Aug.
Article
in English
| MEDLINE
| ID: mdl-37400965
ABSTRACT
An efficient 1,4-dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4-dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT-29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in-silico docking studies were conducted to understand the structure-based features of the anticancer mechanism with the cancer medication target of Adenosineâ A2A receptor as well as the molecular level interactions of the compounds.