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1.
Saudi Med J ; 45(1): 93-97, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38220240

ABSTRACT

OBJECTIVES: To examine the contraceptive preferences of women based on their age and to track changes in these preferences over time. METHODS: This was an observational, retrospective cross-sectional study. Data from 2742 patients were evaluated for this study. The patient group of the first 4 years was classified as Group I (n=1371) and the last 4 years was classified as Group II (n=1371). The preferred contraception methods between the groups and their changes across the years were examined. RESULTS: Coitus interruptus was found to be the prevailing contraceptive method across all age groups, with 304 (70.9%) in 18-24 age group; 1314 (65.4%) in 25-40 age group; and 148 (48.8%) in 41-53 age group using this method. Breastfeeding rates were also analyzed across age groups, revealing that 11% of patients aged 18-24 years, 5% of patients aged 25-40 years, and 1.7% of patients aged 41-53 years were breastfeeding. Among these patients, 114 (74.5%) were not using any contraception method, while coitus interruptus remained the most popular choice. CONCLUSION: It was determined that there are many couples who do not have sufficient knowledge regarding family planning and birth control in our country. At the same time, the use of birth control methods has increased due to the increase in the education level of women and easier access to sexual health services.


Subject(s)
Contraception , Female , Humans , Middle Aged , Contraception/methods , Cross-Sectional Studies , Retrospective Studies , Tertiary Care Centers , Adolescent , Young Adult , Adult
2.
J Obstet Gynaecol Res ; 48(11): 2935-2945, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35908182

ABSTRACT

AIM: To develop a treatment and management algorithm for vulvar abscess. METHODS: We evaluated the clinical findings and treatment modalities of patients hospitalized with vulvar abscess via a comprehensive literature review and a clinical study. Patients with a diagnosis of vulvar abscess (n = 28) between 2015 and 2019 in the gynecology clinic of our hospital were included in the clinical study. Each patient's age, obstetric history, body mass index, presence of concomitant diseases, abscess culture and size, mean length of hospital stay, treatment modalities, and recurrence rate were recorded. RESULTS: The mean age and body mass index of the patients were 47.7 ± 11.5 years and 30.3 ± 2.7 kg/m2 , respectively. Diabetes mellitus was the most common concomitant disease (60.7%, n = 17). The abscesses of 22 (78.5%) patients drained spontaneously. The abscess cavities of the remaining six (21.4%) patients were treated via incisional drainage. Gentamicin + clindamycin or levofloxacin + metronidazole were used as the primary antibiotic treatment. Hemovac drains were placed in four (14.2%) patients with abscess sites greater than 5 cm. By applying our treatment methods, 26 (92.8%) of our patients were discharged with full recovery, and two patients (7.2%) were referred due to uncontrolled diabetes mellitus. The recurrence rate of vulvar abscess was 0%. CONCLUSIONS: This is the first study in the literature to present a successful algorithm for the treatment and management of vulvar abscess. Our treatment methods shed light on the treatment and management of vulvar abscess.


Subject(s)
Abscess , Vulvovaginitis , Female , Humans , Abscess/drug therapy , Tertiary Care Centers , Retrospective Studies , Drainage , Anti-Bacterial Agents/therapeutic use , Algorithms
3.
Clin Respir J ; 16(7): 497-503, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35750636

ABSTRACT

BACKGROUND: The COVID-19 pandemic, which first appeared in Wuhan, China, in December 2019 and spread rapidly around the globe, continues to be a serious threat today. Rapid and accurate diagnostic methods are needed to identify, isolate and treat patients as soon as possible because of the rapid contagion of COVID-19. In the present study, the relation of the semi-quantitative scoring method with computed tomography in the diagnosis of COVID-19 in determining the severity of the disease with clinical and laboratory parameters and survival of the patients were investigated along with its value in prognostic prediction. MATERIAL AND METHOD: A total of 277 adult patients who were followed up in the chest diseases clinic because of COVID-19 pneumonia between 11.03.2020 and 31.05.2020 were evaluated retrospectively in the present study. Both lungs were divided into five regions in line with their anatomical structures, and semiquantitative radiological scoring was made between 0 and 25 points according to the distribution of lesions in each region. The relations between semiquantitative radiological score and age, gender, comorbidity, and clinical and laboratory parameters were examined. RESULTS: A significant correlation was detected between advanced age, lymphopenia, low oxygen saturation, high ferritin, D-dimer, and radiological score in the univariate analysis performed in the present study. The cut-off value of the semiquantitative radiology score was found to be 15 (AUC: 0.615, 95% CI: 0.554-0.617, p = 0.106) in ROC analysis. The survival was found to be better in cases with a radiology score below 15, in Kaplan-Meier analysis (HR: 4.71, 95% CI: 1.43-15.46, p < 0.01). In the radiological score and nonparametric correlation analyses, positive correlations were detected between CRP, D-dimer, AST, LDH, ferritin, and pro-BNP, and a negative correlation was found between partial oxygen pressure and oxygen saturation (p = 0.01, r = 0.321/0.313/0.362/0.343/0.313/0.333/-0.235/-0.231, respectively) CONCLUSION: It was found that the scoring system that was calculated quantitatively in thorax HRCTs in Covid-19 patients is a predictive actor in determining the severity and prognosis of the disease in correlation with clinical and laboratory parameters. Considering patients who have a score of 15 and above with semiquantitative scoring risky in terms of poor prognosis and short survival and close follow-up and early treatment may be effective to reduce mortality rates.


Subject(s)
COVID-19 , Adult , COVID-19/diagnostic imaging , COVID-19/pathology , Ferritins , Humans , Pandemics , Prognosis , Retrospective Studies , Severity of Illness Index , Thorax , Tomography, X-Ray Computed
4.
Perspect Psychiatr Care ; 58(4): 2154-2160, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35124812

ABSTRACT

PURPOSE: This study aims to evaluate the relationship between Type D personality, depression, perceived social support, and disease activity in women with fibromyalgia (FM). DESIGN AND METHODS: One hundred and forty women applied to the physical medicine rehabilitation outpatient clinic between October 2019 and February 2020 who also had been diagnosed with FM were recruited. Age, occupation, marital status, chronic diseases, body mass index, duration of FM, smoking and alcohol use, sleep patterns, difficulty with daily work and self-care, physical therapy, and rehabilitation status were all recorded as demographic data of subjects. All patients participating in the study were evaluated with a Type D Personality Scale, Beck Depression Inventory, Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and Multidimensional Scale of Perceived Social Support (MSPSS). FINDINGS: It has been determined that more than half of the women diagnosed with FM had the disease for more than 2 years, the average age was 46, 70% of patients were 40 years or older, more than half were overweight or obese and 63.6% had Type D personality. Eighty-nine women diagnosed with FM had a Type D personality and a significant correlation was found between Type D personality and depression, VAS, FIQ, and the subparameters of MSPSS. PRACTICAL IMPLICATIONS: The determination of a relationship between the Type D personality and depression, VAS, FIQ, and MSPSS in women with FM plays a very important role in the care of FM in terms of treatment and prognosis and it can be said that determining the personality traits of such patients may be beneficial for clinicians.


Subject(s)
Fibromyalgia , Type D Personality , Humans , Female , Middle Aged , Fibromyalgia/diagnosis , Depression , Pain Measurement , Surveys and Questionnaires , Social Support
5.
An Acad Bras Cienc ; 94(1): e20191476, 2022.
Article in English | MEDLINE | ID: mdl-35018996

ABSTRACT

The aim of present study, to evaluate the genotoxic potential of 1-(4-(3,3-dimethyl-1,6-dioxo-2,3,4,6,11,13-hexahydro-1H-indazolo[1,2b] phthalazine-13yl)phenyl)-2-phenylazetidine-3-yl-acetate which was synthesised assuming that it may be a pharmaceutical raw material and found to inhibit human carbonic anhydrase I, II isozymes. To determine the genotoxic potential of this phthalazine substituted ß-lactam compound, chromosomal aberration (CA) and micronucleus (MN) tests were implemented in human peripheral blood lymphocytes. In these tests, lymphocyte cultures were treated with four concentrations (30, 15, 7.5, 3.75 µg/mL) of test compound and simultaneously with negative control (sterile distilled water), solvent control (DMSO) positive control (MMC). According to our results, CA frequencies were significantly increased in two high applied concentrations (30, 15 µg/mL) compared with negative and solvent control. MN frequencies were significantly increased in three applied concentrations (30, 15, 7.5 µg/mL) except lowest concentration (3.75 µg/mL) compared with solvent control. Mitotic indices were also affected by treatment with test compound. The obtained results provide evidence to demonstrate that new phthalazine substituted ß-lactam derivative can exert genotoxic and cytotoxic effects in peripheral human lymphocytes especially at high concentrations.


Subject(s)
Micronuclei, Chromosome-Defective , beta-Lactams , Cells, Cultured , Chromosome Aberrations/chemically induced , DNA Damage , Dose-Response Relationship, Drug , Humans , Lymphocytes , Micronucleus Tests , Phthalazines/toxicity , beta-Lactams/toxicity
6.
AJNR Am J Neuroradiol ; 42(11): 2077-2085, 2021 11.
Article in English | MEDLINE | ID: mdl-34620587

ABSTRACT

BACKGROUND AND PURPOSE: Neuroimaging has an important role in detecting CNS involvement in children with systemic or CNS isolated hemophagocytic lymphohistiocytosis. We characterized a cohort of pediatric patients with CNS hemophagocytic lymphohistiocytosis focusing on neuroradiologic features and assessed whether distinct MR imaging patterns and genotype correlations can be recognized. MATERIALS AND METHODS: We retrospectively enrolled consecutive pediatric patients diagnosed with hemophagocytic lymphohistiocytosis with CNS involvement treated at 2 pediatric neurology centers between 2010 and 2018. Clinical and MR imaging data were analyzed. RESULTS: Fifty-seven children (40 primary, 70%) with a median age of 36 months (interquartile range, 5.5-80.8 months) were included. One hundred twenty-three MR imaging studies were assessed, and 2 broad imaging patterns were identified. Pattern 1 (significant parenchymal disease, 32/57, 56%) was seen in older children (P = .004) with worse clinical profiles. It had 3 onset subpatterns: multifocal white matter lesions (21/32, 66%), brainstem predominant disease (5, 15%), and cerebellitis (6, 19%). All patients with the brainstem pattern failed to meet the radiologic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. An attenuated imaging phenotype (pattern 2) was seen in 25 patients (44%, 30 studies) and was associated with younger age. CONCLUSIONS: Distinct MR imaging patterns correlating with clinical phenotypes and possible genetic underpinnings were recognized in this cohort of pediatric CNS hemophagocytic lymphohistiocytosis. Disruptive mutations and missense mutations with absent protein expression correlate with a younger onset age. Children with brainstem and cerebellitis patterns and a negative etiologic work-up require directed assessment for CNS hemophagocytic lymphohistiocytosis.


Subject(s)
Brain Diseases , Lymphohistiocytosis, Hemophagocytic , Child , Child, Preschool , Humans , Infant , Lymphohistiocytosis, Hemophagocytic/diagnostic imaging , Lymphohistiocytosis, Hemophagocytic/genetics , Magnetic Resonance Imaging , Neuroimaging , Retrospective Studies
7.
Clin Oncol (R Coll Radiol) ; 25(1): 59-65, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22841149

ABSTRACT

AIMS: To evaluate the prognostic significance of potential tumour markers of hypoxia and apoptosis in early squamous cell carcinoma of the glottic larynx managed with radiotherapy. MATERIALS AND METHODS: In total, 382 patients with T1 and T2 squamous cell carcinoma of the glottic larynx (vocal cords) received radical radiotherapy (50-55 Gy, in 16 fractions in 98% of cases). Pre-treatment haemoglobin was available for 328 patients; biopsy samples were available for 286. Immunohistochemistry was carried out for carbonic anhydrase-9 (CA-9), hypoxia inducible factor-1α (HIF-1α) and Bcl-2. RESULTS: At 5 years, locoregional control was achieved in 88.2%, cancer-specific survival in 95.0% and overall survival in 78.7%. Adverse prognostic factors for locoregional tumour recurrence were pre-treatment haemoglobin <13.0 g/dl (P = 0.035, Log rank test; sensitivity 0.28, specificity 0.84) and stage T2 rather than T1 (P = 0.002). The effect of haemoglobin level on locoregional control was not significant when stratified by the median of 14.2 g/dl (P = 0.43) or as a continuous variable (P = 0.59). High CA-9 (P = 0.11), HIF-1α (P = 0.67) and Bcl-2 (P = 0.77) expression had no prognostic significance. CONCLUSIONS: High CA-9, HIF-1α and Bcl-2 do not add to the prognostic significance of tumour stage and lower haemoglobin in predicting failure of local control in early glottic larynx squamous cell carcinoma managed with radiotherapy. The effect of haemoglobin was not strong enough to be useful as a prognostic biomarker.


Subject(s)
Carbonic Anhydrases/metabolism , Carcinoma, Squamous Cell/radiotherapy , Hypoxia-Inducible Factor 1, alpha Subunit/metabolism , Laryngeal Neoplasms/radiotherapy , Proto-Oncogene Proteins c-bcl-2/metabolism , Vocal Cords/pathology , Biomarkers, Tumor/metabolism , Carcinoma, Squamous Cell/metabolism , Carcinoma, Squamous Cell/pathology , Cell Hypoxia , Disease-Free Survival , Female , Humans , Laryngeal Neoplasms/metabolism , Laryngeal Neoplasms/pathology , Male , Neoplasm Recurrence, Local/radiotherapy , Prognosis , Treatment Outcome
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