[Blood oxygen saturation in various regions of the circulatory system in healthy persons]. / Nasyshchenie krovi kislorodom v razlichnykh otdelakh krovenosnoi sistemy u zdorovogo cheloveka.

The gaseous composition of the blood has been determined in cardiac cavities and major vessels in 180 practically healthy individuals aged from 1 to 30 years, during diagnostic catheterization of the heart. Physiological norms of gaseous composition of the blood in cardiac cavities and in the major blood vessels have been determined. Blood saturation with oxygen in the identical cardiac cavities and the major blood vessels are the same in men and women. The arterial blood having oxygenation below 93% is considered hypoxaemic. Normal figures of oxygenation for venous blood are from 75-84%. Exponential decrease of blood oxygenation with age (arterial and mixed venous) is roughly the same, due to this the arteriovenous difference of oxygenation at rest remains constant and is roughly equal to 20%. Minimum arterio-venous difference in oxygenation is 10%, maximum 40%.

[T- and B-lymphocyte systems in heart surgery patients in the early postoperative period]. / T- i B-limfotsitarnye sistemy u kardiokhirurgicheskikh bol'nykh v rannem posleoperatsionnom periode.

The number of T- and B-lymphocytes, O cells, the IgA, IgG, IgM content, the lymphocyte transformation in vitro and also the haematological parameters of the white blood were studied in 33 patients with rheumatic heart diseases during the inactive phase of the illness and in 25 operated on patients on the 1st-10th post-operative days. On the 1st-3rd day after the operation marked (3-4-fold) decrease of the absolute number of T- and B-lymphocytes was recorded. The immunological parameters recovered by the 5th-7th days after surgery. On the 10th day they exceed their initial levels. The authors believe it possible to use these data in elaborating the program of immunological control in cardiosurgical patients.

[ABO and Rh blood groups in cardiovascular pathology]. / Gruppy krovi sistem ABO i Rh u bol'nykh s serdechno-sosudistoi patologiei.

A relationship between erythrocytic antigens of the ABO and Rh blood systems and cardiovascular pathology was revealed by comparing the distribution of blood groups in 13,175 patients and 7,800 donors. Prevalence of A gene and Rh+ phenotype in congenital and acquired heart diseases and ischemic heart disease was found. The frequency of B gene is increased in patients with acquired heart diseases.

[Work capacity of mitral stenosis patients before and after mitral commissurotomy]. / Trudosposobnost' bol'nykh mitral'nym stenozom do i posle mitral'npi komissurotomii.

Analysis of the working capacity of 1,000 patients who underwent mitral commissurotomy showed that 67.0% of individuals who were operated on for grade III stenosis and 27.99% of those operated on for grade IV stenosis resumed work. Frequent exacerbations of rheumatism and changes in the myocardium and valvular apparatus are among the causes of the decrease in the number of persons who resume work after the operation. Another reason is overestimation of the group of invalidity or its unjustified qualification

[Lactae dehydrogenase activity and its isoenzymatic spectrum in the myocardium in rheumatic heart defects]. / Aktivnost' laktatdegidrogenay i ee izofermentnyi spektr v miokarde bol'nykh revmaticheskimi porokami serdtsa.

The activity of lactate dehydrogenase (LDH) and its isoenzymatic spectrum were studied in biopsy specimen of the myocardium of 35 patients with mitral valvular disease who underwent operation. Starch gel electrophoresis was used. Four fractions of LDH isoenzymes were detected: LDH1, LDH2, LDH3, and LDH4. A definite metabolic trend of their changes in different stages of the disease was determined. LDH1 activity was considerably increased in patients with stage III mitral stenosis who had complications in the postoperative period. This is evidence of unstable compensation in patients of this group and may indicate the possible development of complications in the early postoperative period.

[Choice of heart surgery patients by the medical census method]. / Otbor kardiokhirurgicheskikh bol'nykh metodom meditsinskoi perepisi.

Cardiosurgical patients were selected in Novosibirsk during medical census of persons suffering from valvular disease; 2244 (81.2%) patients with congenital valvular diseases and 3979 (51.5%) those with acquired valvular diseases were chosen for operative treatment. Among patients with congenital valvular diseases, 12.1% underwent operation, surgery was indicated in 32.5%, and a follow-up of the pathological process was recommended in 36.6% of patients. In the group of acquired valvular diseases, 7.0% of patients were operated on, operation was indicated in 27.6%, and a follow-up recommended in 51.5% of patients.

[Classification of acquired aortic stenosis (based on electrocardiographic study data)]. / O klassifikatsii priobretennogo aortal'nogo stenoza (po dannym élektrokardiograficheskogo issledovaniia).

The article is based on the case records of 192 patients with acquired aortic stenosis and interpretation of the ECG of 187 patients. In this group, 143 patients underwent operation and 8 died in the period of their examination. The purpose of the examination consisted in determining whether or not the ECG could characterize the stage of the cardiac disease. Four types of electrocardiographic changes of the ventricular complex characteristic of left-ventricular hypertrophy were distinguished. On comparing clinical and electrocardiographic findings, no clear dependence was revealed between the clinical manifestations of the stenosis and the severity of the hypertrophic process in the muscle of the left ventricle according to the ECG data. The information gained by means of ECG is confirmed by the results of pathomorphological examination. The authors suggest a clinical classification of acquired aortic stenosis based on the function changes in the left-ventricular myocardium as determined from the ECG.

[Course of the rheumatic process in mitral heart defects after primary and repeated courses of treatment with titrated gamma-globulin]. / Techenie revmaticheskogo protsessa u bol'nykh mitral'nymi porokami serdtsa posle pervichnykh i povtornykh kursov lecheniia titrovannym gamma-globulinom.

Titrated gamma-globulin, which the authors used in the preoperative management of patients with acquired valvular disease and minimum rheumatism activity, contained high titers of antibodies against the antigens of streptococcus (streptokinase, streptohyaluronidase, streptolysin 0) and Coxsackie A13, A18, and B3 viruses. Its use in combination with antirheumatic agents did not cause any complications and made it possible to reduce the activity of the process in most cases with grade I and after repeated courses also in grade II activity of rheumatism. Treatment with titrated gamma-globulin stimulates the organism's defence forces (factors of nonspecific immunity: complement, lysozyme, interferon) and leads to diminution of the isolation of cardiotropic viruses from blood and bioptic material of the atria of patients.

[Evolution of lesser circulation hypertension in patients with congenital heart defects based on the example of an interventricular septal defect]. / Evoliutsiia gipertonii malogo kruga u bol'nykh vrozhdennymi porokami serdtsa na primere bol'nykh s defektom mezhzheludochkovoi peregorodki.

The results of direct pressure measurement in pulmonary circulation in 452 patients with ventricular septal defect (216 males and 236 females), whose age ranged from 12 months to 37 years, were analysed. The findings of diagnostic catheterization of the heart in 150 practically healthy persons 12 months to 40 years of age were used to elaborate the normal values of pressure in pulmonary circulation. The results of pressure measurement in pulmonary circulation repeated at intervals of 1 to 6 years in 46 patients with ventricular septal defect, 18 months to 23 years of age, were analysed. Reverse evolution of pressure in pulmonary circulation after surgical rehabilitation was followed up in 85 patients in 1, 2, 3, 5, and 7 years after the operation. At the age of 12 months to 7 years, systolic pressure in the right ventricle and pulmonary artery comes down to a possible minimum due to expenditure of the adaptational reserve. In large ventricular septal defects, however, the organism proves incapable of reducing the pressure in the early and first periods of childhood as a rule, and so the pressure increases throughout life.