[Synthesis, isomery, and hypotensive activity of thiethane-containing ylidenehydrazides of uracilylacetic acid].

Using reaction of hydrazide 2-[6-methyl-1-(thiethane3-yl)uracil-3-yl]acetic acid with arylaldehydes and acetophenone derivatives were obtained acylhydrazones, which exist in DMSO solution as a mixture of two stereoisomers of a E(C=N)-isomer for due to hindered internal rotation around the hydrazide bond. It was revealed that the synthesized compounds exhibit antihypertensive activity.

[Role of certain neurohumoral factors in development of pulmonary hypertonia in patients with interstitial lung diseases]. / Rol' nekotorykh neirogumoral'nykh faktorov v razvitii legochnoi gipertonii u bol'nykh interstitsial'nymi bolezniami legkikh.

AIM: To ascertain the role of some neurohumoral factors--nitric oxide (NO), ACE, histamine--in development of pulmonary hypertension (PH) in patients with interstitial lung diseases (ILD). MATERIAL AND METHODS: A total of 32 ILD patients were examined. Of them 14 had idiopathic fibrosing alveolitis (IFA), 6 had exogenous allergic alveolitis (EAA) and 12 patients had ILD in diffuse disease of the connective tissue (ILD-DDCT). In addition to routine tests, those for NO, ACE, histamine, serotonin in plasma were performed; Doppler echocardiography and high-resolution computed tomography were conducted. In 9 patients the diagnosis was verified at thoracoscopic biopsy of the lung. The control group consisted of 16 healthy subjects. RESULTS: The highest mean pressure in the pulmonary artery (PmPA) was registered in IFA vs EAA and ILD-DDCT patients (p < 0.001). NO concentration in plasma was higher in ILD-DDCT than in control patients. In IFA and EAA the level of NO was like in controls. Concentration of NO in plasma of IDL patients correlated with high activity of the process. No correlation was found between ACE in plasma and PmPA, ACE levels were much higher in controls than in the ILD patients (p < 0.05). Histamine levels were higher in ILD patients than in controls being the highest in ILD-DDCT. Serotonin was insignificantly higher in ILD patients than in controls. CONCLUSION: Damage to the endothelium of the pulmonary arteries and imbalance of neurohumoral factors may be considered as a mechanism of development and stabilization of PH in ILD patients.

[Magnetic storms as a stress factor]. / Magnitnye buri kak stressovyi faktor.

The functional characteristics variations during the magnetic storms were observed in both the healthy humans and in patients with cardio-vascular diseases as well as in cosmonauts at SOYUZ spacecraft and MIR station. These characteristics revealed a nonspecific adaptive stress reaction, which should be accompanied by the variations in the stress-hormone production rate. The neurohumoral regulation of the organism functions during the geomagnetic storms in a group of patients with cardio-vascular pathology and in a control group of healthy individuals were studied. The magnetic storm effect characterised of both the sick and healthy examines was the violated ratio of glucocorticoids and mineralocorticoids, namely increase of cortisone secretion (adrenal cortex hormone), as well as some tendency to the activation of sympathoadrenal system. Our investigations revealed also a suppressed production of melatonin (the pineal gland hormone) during the geomagnetic storm. These results are not in contradictions with the functional characteristics violation by the magnetic storms and correspond to the existence of adaptive stress reaction of the human organism to the geomagnetic field disturbances.

[The role of hemosorption in preventing and treating pulmonary disorders in patients with peritonitis and acute intestinal obstruction]. / Rol' gemosorbtsii v profilaktike i lechenii legochnykh rasstroistv u bol'nykh peritonitom i ostroi neprokhodimost'iu kishechnika.

An analysis of treatment and examination of 80 patients with peritonitis and acute intestinal obstruction of different etiology has been made when hemosorption was used for struggle against intoxication. It has been shown that hemosorption possessing a potent detoxicating effect considerably facilitates activation of the non-gas-exchange functions of the lungs. However, losses of the surfactant synthesis components during hemocarboperfusion as well as absorption of oxygen by certain sorts of charcoal (SKN-4M, SKN-1K) results in arterial hypoxemia. For prophylactics and treatment of pulmonary disorders in patients with peritonitis and acute intestinal obstruction hemosorption must be supplemented with repeated sessions of spontaneous respiration with positive pressure at the end of breathing out.

[Functional state of the lungs in toxemia in peritonitis and acute intestinal obstruction]. / Funktsii legkikh v usloviiakh intoksikatsii pri peritonite i ostroi neprokhodimosti kishechnika.

On the basis of examination of 214 patients, it was established that the pronounced intoxication syndrome developing in peritonitis and acute ileus led to disorders in the non-respiratory pulmonary functions. This contributes to the development of arterial hypoxemia, hypocapnia and acute respiratory failure. In the complex of treatment of the patients, it is expedient to use extracorporeal desintoxication.

[The interrelationship between serotonin and lipid peroxidation products during experimental wound healing]. / Vzaimosviaz' serotonina i produktov lipoperoksidatsii v protsesse zazhivleniia ran v éksperimente.

On 220 male Wistar rats with models of aseptic and contaminated skin wounds the authors studied interrelationship between serotonin and hydroperoxide in the wound tissues and the blood. A comparative analysis of the changes of these indices in the blood and tissues showed that the degree of these disorders on the 1st day after the operation was determined by operational trauma and with the development of purulent inflammation intensive initiation of lipoperoxidation products takes place.

[Effect of myocardial ischemia on prostacyclin and thromboxane levels in arterial and coronary venous blood]. / Vliianie ishemii miokarda na soderzhanie prostatsiklina i tromboksana v arterial'noi i koronarnoi venoznoi krovi.

Variations in arterial and venous blood prostacyclin and thromboxane were examined in 32 patients with coronary heart disease, neurocirculatory dystonia and the cardialgic syndrome, exposed to cardioselective stress as a result of the atrial stimulation test. Prostacyclin and thromboxane measurement in blood specimens obtained from the left ventricle and the coronary venous network may provide additional markers of myocardial ischemia in cases where diagnosis is otherwise difficult to make.

[Characteristics of the functioning of the human hypophyseal-gonadal system during 1-time sleep deprivation]. / Osobennosti funktsionirovaniia gipofizarno-gonadnoi sistemy cheloveka v usloviiakh odnokratnoi deprivatsii sna.

The authors studied indices of the activity of the hypophyseogonadal system under the conditions of single sleep deprivation of 24-36 h duration and in the period of recovery. Eleven healthy men aged 21 to 26 were recruited in the study. Two series of investigations were performed: I--the examinees were studied before, after 24 h sleep deprivation and after the first recovery night; II--the scheme of investigation was identical but it included electroauriculopuncture 5-6 h after the start of sleep deprivation. The 24 h sleep deprivation was accompanied by an increase in ACTH and LH secretion, a decrease in the levels of STH, prolactin, total androgens and progesterone in the examinees' blood. On the whole, electroauriculopuncture optimized the activity of the hypophyseogonadal system expressed in lesser changes in the secretion of the above hormones in response to sleep deprivation.

[Prostaglandins A1, E1 and F2 alpha concentrations in the arterial and coronary venous blood of patients with ischemic heart disease during induced myocardial ischemia]. / Soderzhanie prostaglandinov A1, E1, F2 alpha v arterial'noi i koronarnoi venoznoi krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa pri indutsirovannoi ishemii miokarda.

Prostaglandins (PGA1, PGE1 and PGF2 alpha) were assayed in 15 patients with chronic coronary disease during an anginal attack induced through frequent atrial stimulation. Measurements from eleven patients with intact coronary arteries served as control. Lactate extraction coefficient was used as a biochemical indicator of myocardial ischemia; the latter was associated with increased production of coronary sinus PGF2 alpha and arterial PGA1. No correlation could be established between PG levels in the studied series, the extent of ST depression on electrocardiograms, lactate extraction level and hemodynamic manifestations.

[State of tissue-vascular permeability in diabetic patients with parodontosis]. / Sostoianie sosudisto-tkanevoi pronitsaemosti u bol'nykh parodontozom pri sakharnom diabete.

The state of the parodontium was studied clinically and morphologically in 70 patients suffering from diabetes mellitus. Blood histamine and serotonin level was determined fluorometrically. Gingivitis was revealed in diabetic patients; the severity of inflammatory changes in the gingiva proved to depend on the duration and the severity of diabetes mellitus. Changes pointing to increase of the vaso-tissue permeability were revealed histologically. At the same time there was an increase in the blood histamine level and a tendency to reduction of serotonin level. This can serve as one of the factors causing an increase of the vascular permeability and a disturbance of microcirculation in the gingiva.