Subject(s)
Hand/pathology , Nevus, Blue/pathology , Skin Neoplasms/pathology , Adult , Humans , MaleABSTRACT
Erythromelalgia is a rare disorder characterized by 3 major symptoms: warmth, redness, and burning pain. It involves the feet and, to a lesser extent, the hands, head, and ears. We report the case of a 27-year-old man presenting with a 15-year history of episodes with edema, local hyperthermia, and burning pain of both ears.
Subject(s)
Ear Auricle/pathology , Erythromelalgia/diagnosis , Adult , Chronic Pain/etiology , Erythromelalgia/complications , Humans , MaleABSTRACT
Clustered or agminated juvenile xanthogranuloma (JXG) is an unusual form of JXG characterized by multiple reddish-brown or yellowish papules and nodules in a coalescent pattern. We report a case of clustered JXG involving the left lower back of a 5-month-old boy.
Subject(s)
Skin/pathology , Xanthogranuloma, Juvenile/diagnosis , Xanthogranuloma, Juvenile/pathology , Back , Biopsy , Diagnosis, Differential , Humans , Infant , Male , Xanthogranuloma, Juvenile/congenitalABSTRACT
No disponible
Subject(s)
Humans , Skin Ulcer/microbiology , Herpes Simplex/diagnosis , Immunocompromised Host/immunology , Simplexvirus/isolation & purificationSubject(s)
Adenocarcinoma/secondary , Penile Neoplasms/secondary , Prostatic Neoplasms/pathology , Skin Neoplasms/secondary , Adenocarcinoma/therapy , Diagnosis, Differential , Humans , Lymphatic Metastasis , Male , Middle Aged , Pelvis , Penile Neoplasms/diagnosis , Penile Neoplasms/drug therapy , Prostatic Neoplasms/therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/drug therapyABSTRACT
No disponible
Subject(s)
Humans , Male , Young Adult , Hair Removal/adverse effects , Folliculitis/microbiology , Pseudomonas aeruginosa/pathogenicity , Pseudomonas Infections/transmissionABSTRACT
No disponible
Subject(s)
Humans , Female , Young Adult , Cocaine-Related Disorders/complications , Maxillary Sinusitis/chemically induced , Diagnosis, DifferentialABSTRACT
BACKGROUND: Management of facial extensive recurrent basal cell carcinoma can be a challenge for dermatologists. Although the preferred technique is usually Mohs surgery, sometimes the patient's condition or predicted aggressive surgery make other options advisable. METHODS: We describe a case of a giant recurrent basal cell carcinoma in the face of an old woman successfully treated by combined therapy with MAL-photodynamic therapy and topical 5%. RESULTS: The patient remains well and with no sign of the tumor, with very good cosmetic result two years after treatment. CONCLUSIONS: Management of extensive facial basal cell carcinoma with combined therapies, as photodynamic therapy followed by topical imiquimod, can be an option for selected cases such as ours.
Subject(s)
Aminoquinolines/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Facial Neoplasms/drug therapy , Neoplasm Recurrence, Local/drug therapy , Photochemotherapy , Skin Neoplasms/drug therapy , Aged, 80 and over , Aminolevulinic Acid/analogs & derivatives , Aminolevulinic Acid/therapeutic use , Carcinoma, Basal Cell/surgery , Facial Neoplasms/surgery , Female , Humans , Imiquimod , Photosensitizing Agents/therapeutic use , Skin Neoplasms/surgeryABSTRACT
BACKGROUND: Photodynamic therapy (PDT) and imiquimod are the treatments of choice for actinic keratosis (AK). As they have different mechanisms of action, it seems reasonable to assume that applying both treatments sequentially would be efficacious. OBJECTIVES: We sought to determine which of these therapeutic modalities provides a better clinical and histologic response in patients with AK and whether sequential use of both was more efficacious than each separately. METHODS: Patients were randomly assigned to one treatment group: group 1, PDT only; group 2, imiquimod only; or group 3, sequential use of PDT and imiquimod. The primary outcome measure was complete clinical response. Partial clinical response was defined as a reduction of more than 75% in the initial number of lesions. A complete clinicopathologic response was defined as lack of evidence of AK in the biopsy specimen. RESULTS: In all, 105 patients completed the study (group 1, 40 patients; group 2, 33 patients; group 3, 32 patients). Sequential application of PDT and imiquimod was more efficacious in all the outcome measures. More patients were satisfied with PDT than with the other two modalities (P = .003). No significant differences were observed among the 3 modalities and tolerance to treatment. LIMITATIONS: Only one cycle of imiquimod was administered. The follow-up period was brief. CONCLUSIONS: Sequential application of PDT and imiquimod provides a significantly better clinical and histologic response in the treatment of AK than PDT or imiquimod monotherapy. It also produces less intense local reactions and better tolerance and satisfaction than imiquimod monotherapy.
