ABSTRACT
7 beta-[2-(2-Aminooxazol-4-yl)-2-Z-methoximinoacetamido]-3-cep hem -4-carboxylic acids 12 and 13 were synthesized. The microbiological activity of 12 and 13 as well as the beta-lactamase stability of 12 were discussed. Both 12 and 13 were quite active against a wide variety of microorganisms although usually less active than cefotaxime.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Cephalosporins/chemical synthesis , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Cefotaxime/pharmacology , Cephalosporins/pharmacology , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , beta-Lactamases/metabolismABSTRACT
Several fenoprofen salts were prepared to obtain the most acceptable form for an oral dosage formulation. Thermal analysis techniques were used to compare stabilities of the water of hydration in different salt forms and to assess the effects of the water of hydration on compatibility with propoxyphene and codeine salts. Photodegradation products of fenoprofen were isolated and identified, and their relevance to product formulation was evaluated.
