Subject(s)
Cyanosis/etiology , Ovarian Neoplasms/diagnosis , Teratoma/diagnosis , Adult , Agglutinins/blood , Cryoglobulins , Cyanosis/blood , Diagnosis, Differential , Female , Hemagglutinins/blood , Humans , Ovarian Neoplasms/blood , Ovarian Neoplasms/complications , Ovarian Neoplasms/surgery , Teratoma/blood , Teratoma/complications , Teratoma/surgeryABSTRACT
Platelet alpha-granule release in 22 patients affected by chronic myeloproliferative disorders with thrombocytosis and seven subjects with thrombocytosis secondary to splenectomy were studied. We found elevated beta-thromboglobulin (BTG) and platelet factor 4 (PF4) plasma levels in all patients. Intraplatelet content of BTG and PF4 was decreased in patients with idiopathic thrombocythaemia (IT) and idiopathic myelofibrosis (IMF). The BTG and PF4 results were also expressed as the ratio plasma BTG and PF4: whole blood platelet count. In patients with IT, BTG: whole blood platelet count ratio was low, conversely, the same ratio was high in patients with IMF. In conclusion, our results suggest the presence of an abnormal, BTG-deficient clone in IT and a peripheral platelet activation in IMF.
Subject(s)
Beta-Globulins/metabolism , Blood Platelets/metabolism , Myeloproliferative Disorders/blood , Platelet Factor 4/metabolism , Thrombocytosis/blood , beta-Thromboglobulin/metabolism , Chronic Disease , Humans , Platelet CountABSTRACT
We studied beta-thromboglobulin (BTG) and platelet factor 4 (PF4) plasma levels in 90 diabetic subjects; we found high plasma values of these proteins only in patients with complications. To provide further indications regarding the role of platelet activation in the pathogenesis of diabetic microangiopathy, we also tested mobilizable platelet content of BTG and PF4; we found these similar to those of normal subjects.
Subject(s)
Beta-Globulins/analysis , Blood Platelets/analysis , Diabetic Angiopathies/blood , Platelet Factor 4/analysis , beta-Thromboglobulin/analysis , Adolescent , Adult , Aged , Child , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Female , Humans , Male , Middle AgedABSTRACT
A case of pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy) is presented. This chronic and usually self-limited condition must be differentiated from other diseases, such as acromegaly, the osteoarthropaties complicating disorders of the connective tissue and osteoarthropaties in paraneoplastic syndromes.
