Scedosporium apiospermum atrial mycetomas after lung transplantation for cystic fibrosis.

A 37-year-old patient with cystic fibrosis underwent double lung transplantation. She developed disseminated Scedosporium apiospermum infection 2 months after surgery. Along with multiple brain abscesses, lung infection, and chorioretinitis, a cardiac echo revealed 2 large intra-atrial mycetomas floating close to the right upper pulmonary vein orifice. The mycetomas were removed through a trans-atrial approach under cardiopulmonary by pass; histology and cultures confirmed the diagnosis. Despite intensive treatment, the patient succumbed from massive brain hemorrhage on the 10th postoperative day.

Fenoldopam and gastric tonometry during orthotopic liver transplantation.

UNLABELLED: The aim of this study was to evaluate the effects of continuous infusion of fenoldopam on splanchnic perfusion in orthotopic liver transplant (OLT) recipients. PATIENTS AND METHODS: We enrolled 40 patients of mean age 57+/-16 years who underwent (OLT). They were randomly divided into two double blinded groups; continuous fenoldopam (0.06 mcg/kg per minute) or placebo infusion. Hemodynamics, gastric tonometry, urine output, renal function parameters, and diuretics use were collected during selected phases of the surgery and postoperatively every 12 hours for 72 hours in the intensive care unit. RESULTS: No significant differences were observed between the two groups concerning hemodynamics, though in the fenoldopam group we observed increased splanchnic perfusion during the whole study period but particularly after arterial unclamping (pHi 7,31+/-0.04 vs 7.28+/-0.05; P < .05) and at 48 hours after surgery (pHi 7.49+/-0.15 vs 7.39+/-0.15; P < .05). Creatinine and blood urea nitrogen values were slightly higher in the placebo group, but this data did not reach statistical significance, while higher doses of furosemide were administered to the placebo group to maintain a urinary output over 200 mL/hour during the whole study. DISCUSSION: In this study we observed that continuous fenoldopam infusion (0.06 mg/kg per minute) improved splanchnic perfusion without affecting systemic pressure. CONCLUSION: Patients undergoing OLT have altered splanchnic perfusion related to cirrhosis, surgical manipulation, and fluid shifts during and after surgery. The use of a splanchnic vasodilator drug improved outcomes in these patients.

Interhemispheric transfer of visual information in schizophrenics.

Groups of 12 male schizophrenic inpatients and 12 normal controls of the same age, sex, and schooling underwent a tachistoscopic test. Each subject was shown an alphabetical letter which he subsequently had to recognize among various other alphabetical letters also shown tachistoscopically. The visual hemifields of the two displays were ipsilateral and crossed. Relative to the normal group the schizophrenics showed higher perceptual thresholds, lower over-all mean performance, and greater lateralization. The results are discussed in terms of rigidly and poorly integrated systems of analysis of information between one hemisphere and the other for schizophrenic patients.

Perceptual experience in learning to read.

A group of 24 children (12 boys and 12 girls) aged 10 yr. was given the Children's Embedded Figures Test and a Reading Ability Test on Comprehension, Accuracy, and Speed. Only the correlation of CEFT and Accuracy scores was statistically significant, while that for CEFT and Comprehension scores fell just short of significance, and that for CEFT and Speed was nonsignificant. Data are discussed in terms of more holistic and more articulated processes in learning to read, respectively, as adopted by more field-dependent and more field-independent subjects.

Hemispheric functionality patterns between dextrals and sinistrals in tactile-visual tasks at lower or higher level of mental processes.

Two different patterns of unilateral tactile-visual recognition tasks with random shapes were administered to 64 subjects, 32 right-handed (16 males, 16 females) and 32 left-handed (16 males, 16 females). The main effects were found in the over-all performance: dextral subjects performed better than sinistral subjects; males performed better than females. On the task at a lower level of mental process dextral subjects performed better over-all than the sinistral subjects; however, neither group showed superiority of one hand over the other. On the task at a higher level of mental process performance of sinistral subjects improved to a level equivalent to that of the dextral subjects. Dextral subjects tended to perform better with their left hands, whereas the sinistral subjects scored equally with both hands. The findings are discussed in terms of quantitative and qualitative differences in patterns of hemispheric functionality between dextral and sinistral subjects, and the more specific cerebral activation for tasks at a higher level of mental process is hypothesized.

Children's reaction times to verbal and nonverbal tachistoscopic stimuli exposed to the left and right visual hemifields.

Tachistoscopic tests of the left and right visual hemifields to identify three-letter words and simple geometric figures were administered to 64 children (32 boys, 32 girls) in the age group 7 to 8 yr. and in their second year of school. The results show no significant differences in visual perceptual threshold between the two hemifields for either of the two tests (three-letter words and simple geometric figures). The authors interpret the results as confirming a lesser and not definitely determined lateralization in children.