ABSTRACT
AIM: To assess the possible association between three-year global mortality and atrial fibrillation (AF) in 328 community-dwelling participants aged 85 at baseline. METHODS: Sociodemographic data, comorbidity and geriatric assessment tools, thromboembolic risk, and AF therapy were assessed. We compared the patients who survived with those who died. RESULTS: At baseline, 41 (12.5%) of participants had permanent AF, and 13 of them died (31.7%) after the three-year follow-up period compared with 44 (15.3%) of the rest of cohort (P = 0.01). Cox regression analysis identified two significant clinical variables as independent predictors of three-year risk of global mortality: Lawton Index (hazard ratio 0.82, 95% confidence interval 0.75-0.91) and AF (hazard ratio 1.90, 95% confidence interval 1.01-3.56). None of the other of variables evaluated showed predictive value of global mortality in the AF patients. CONCLUSION: In oldest old community-dwelling participants, AF is an independent risk factor for global mortality after a three-year follow-up period.
Subject(s)
Atrial Fibrillation/mortality , Independent Living , Age Factors , Aged, 80 and over , Aging , Atrial Fibrillation/diagnosis , Chi-Square Distribution , Female , Follow-Up Studies , Geriatric Assessment , Humans , Kaplan-Meier Estimate , Linear Models , Male , Prognosis , Proportional Hazards Models , Prospective Studies , Risk Assessment , Risk Factors , Spain/epidemiology , Time FactorsABSTRACT
Objetivos. Analizar la prescripción según criterios de idoneidad de STOPP (Screening Tool of Older Person's Prescriptions) y de Beer's y los factores asociados en personas de 85 años. Pacientes y métodos. Estudio transversal de prescripción inadecuada a los 85 años. Se registraron: variables sociodemográficas, factores de riesgo cardiovascular, enfermedades crónicas, polifarmacia (4 o más) y valoración geriátrica. La prescripción inadecuada (PI) se valoró según prescripción total y cardiovascular. Resultados. La media de fármacos en el total de 78 sujetos fue 6,1 (3,3). El 34,6% de pacientes tenían un fármaco de PI; el 19,2% tenían dos; el 15,4% tenían tres o más, y en total, el 69,2% de pacientes presentaban algún fármaco de PI; el 37,2% tenía uno o más fármacos de PI cardiovascular. Los grupos terapéuticos responsables del total de PI fueron benzodiazepinas (BZP) 23,1%, diuréticos del asa 17,9%, inhibidores de recaptación de la serotonina (ISRR) 16,7% y los antiinflamatorios no esteroideos (AINE) representaron un 10,3% del total de criterios. El análisis bivariado halló asociación de número de fármacos y polifarmacia (p=0,030 en ambos) con PI total; no se halló significación en PI cardiovascular. El análisis multivariante mostró asociación de polifarmacia (OR: 1,22; IC 95% 1,02-1,47; p=0,031) para la PI total y de dislipemia (OR: 0,30; IC 95% 0,10-0,87; p=0,026) y de HTA (OR: 0,15; IC 95% 0,03-0,78; p=0,024) para la PI cardiovascular. Conclusiones. Más de la mitad de los pacientes de 85 años recibió una prescripción inapropiada. Dislipemia e HTA se asociaron a prescripción inapropiada cardiovascular y los grupos más frecuentes fueron BZP, diuréticos, ISRR y AINE(AU)
Objectives. To analyse the prescription according to the STOPP (Screening Tool of Older Person's Prescriptions) and Beer's suitability criteria, and associated factors in patients over 85 years-old. Patients and methods. Cross-sectional study of inappropriate prescribing to over 85 year-olds. The data recorded were: sociodemographic variables, cardiovascular risk factors, chronic illnesses, multiple medication (or polypharmacy) (4 or more) and geriatric assessment. The inappropriate prescription (IP) was evaluated according to total and cardiovascular prescription. Results. The mean number of drugs in the total of 78 subjects was 6.1 (3.3). Of the total number, 34.6% patients had 1 IP drug; 19.2% had 2; 15.4% had 3 or more, and in total 69.2% of patients had at least one IP drug, and 37.2% had 1 or more IP cardiovascular drugs. The therapeutic groups involved in the overall IP were benzodiazepines (BZP) 23.1%, loop diuretics 17.9%, selective serotonin reuptake inhibitors (SSRIs) 16.7%, and non-steroidal anti-inflammatory drugs (NSAIDs) made up 10.3% of the total criteria. The bivariate analyse found a relationship between the number of drugs and multiple medication (P=.030 in both) and total IP, with no significance found in cardiovascular IP. The multivariate analysis showed an association between multiple medication (OR: 1.22; 95% CI: 1.02-1.47; P=.031) and total IP, and dyslipaemia (OR: 0.30; 95% CI: 0.10-0.87; P=.026) and AHT (OR: 0.15; 95% CI: 0.03-0.78; P=.024) for cardiovascular IP. Conclusions. More than half the over 85 year-old patients received an inappropriate prescription. Dyslipaemia and AHT are associated with an inappropriate cardiovascular prescription, and the most frequent drug groups were, BZP, diuretics, SSRIs, and NSAIDs(AU)
Subject(s)
Humans , Male , Female , Aged, 80 and over , Medication Errors/prevention & control , Medication Systems/trends , Risk Factors , Cardiovascular Diseases/complications , Chronic Disease/epidemiology , Chronic Disease/prevention & control , Drug Prescriptions/standards , Prescription Drugs , Medication Therapy Management/trends , Hyperlipidemias/drug therapy , Cross-Sectional Studies , Polypharmacy , Drug Antagonism , Multivariate AnalysisABSTRACT
OBJECTIVES: To analyse the prescription according to the STOPP (Screening Tool of Older Person's Prescriptions) and Beer's suitability criteria, and associated factors in patients over 85 years-old. PATIENTS AND METHODS: Cross-sectional study of inappropriate prescribing to over 85 year-olds. The data recorded were: sociodemographic variables, cardiovascular risk factors, chronic illnesses, multiple medication (or polypharmacy) (4 or more) and geriatric assessment. The inappropriate prescription (IP) was evaluated according to total and cardiovascular prescription. RESULTS: The mean number of drugs in the total of 78 subjects was 6.1 (3.3). Of the total number, 34.6% patients had 1 IP drug; 19.2% had 2; 15.4% had 3 or more, and in total 69.2% of patients had at least one IP drug, and 37.2% had 1 or more IP cardiovascular drugs. The therapeutic groups involved in the overall IP were benzodiazepines (BZP) 23.1%, loop diuretics 17.9%, selective serotonin reuptake inhibitors (SSRIs) 16.7%, and non-steroidal anti-inflammatory drugs (NSAIDs) made up 10.3% of the total criteria. The bivariate analyse found a relationship between the number of drugs and multiple medication (P=.030 in both) and total IP, with no significance found in cardiovascular IP. The multivariate analysis showed an association between multiple medication (OR: 1.22; 95% CI: 1.02-1.47; P=.031) and total IP, and dyslipaemia (OR: 0.30; 95% CI: 0.10-0.87; P=.026) and AHT (OR: 0.15; 95% CI: 0.03-0.78; P=.024) for cardiovascular IP. CONCLUSIONS: More than half the over 85 year-old patients received an inappropriate prescription. Dyslipaemia and AHT are associated with an inappropriate cardiovascular prescription, and the most frequent drug groups were, BZP, diuretics, SSRIs, and NSAIDs.
