ABSTRACT
BACKGROUND: A ruptured abdominal aortic aneurysm (rAAA) is a life-threatening condition, with high mortality rates. The Shock Index (SI) is an easy tool and a useful predictor of hemodynamic instability in trauma patients. We aimed to assess the predictive and prognostic value of the SI for patients with a suspected rAAA in the prehospital and hospital setting. METHODS: This was a retrospective, observational, single-center study. Patients >18 years old who visited the emergency department with a suspected rAAA between January 2009 and December 2018 were included. Prehospital and hospital SI were calculated and analyzed for its predictive value on the presence of a rAAA, need for packed cells (PCs) and mortality. RESULTS: A total of 313 patients met the inclusion criteria, of which 71 patients (22.6%) presented with a rAAA. Prehospital and hospital SI were significantly increased in the rAAA group. A SI ≥ 1.0 was estimated as an optimal cutoff point for the presence of a rAAA (AUROC 0.74, 95% CI 0.67-0.82; p < 0.001) with an adjusted Odds Ratio (OR) of 5.3 (95% CI 2.13-13.39) for the prehospital SI and an adjusted OR of 18.2 (95% CI 5.83-56.73) for the hospital SI. Both prehospital and hospital SI ≥ 1.0 were associated with a higher need for PCs and amount of PCs (p < 0.05). A hospital SI ≥ 1.0 was associated with higher in-hospital mortality rates (39.0% vs 68.0%, p = 0.022). CONCLUSIONS: The prehospital and hospital SI were significantly elevated in the rAAA group. As such, the SI showed promising results as a predictive and prognostic tool, with SI ≥ 1.0 as cutoff point.
Subject(s)
Aortic Aneurysm, Abdominal , Aortic Rupture , Emergency Medical Services , Adolescent , Aortic Aneurysm, Abdominal/diagnosis , Hospital Mortality , Humans , Retrospective Studies , Risk Factors , Treatment OutcomeABSTRACT
BACKGROUND: Ischemia-reperfusion injury of donor kidneys may worsen transplant outcome. Kidneys with severe injury, such as kidneys of donors after circulatory death, develop edema, which may lead to renal compartment syndrome with reduced tissue perfusion. OBJECTIVE: We studied the effect of capsulotomy during hypothermic machine perfusion (HMP) of ischemically damaged porcine kidneys. METHODS: Eight pairs of kidneys from slaughterhouse pigs were assigned to two groups (20 and 45 min of warm ischemia). After 21 h of HMP, capsulotomy was performed, and perfusion was continued for 2 h. During perfusion, machine flow (Q), renal resistance (RR), renovascular circulating volume (RCV), intraparenchymal pressure (IPP) and weight were recorded. Parenchymal injury was examined with methylene blue infusion. RESULTS: Mean Q and RCV increased directly after capsulotomy [percentage increase (95% confidence interval): x0394;Q = 32% (17, 47), p = 0.001, and x0394;RCV = 19% (3, 35), p = 0.023]. Mean RR decreased [x0394;RR = -23% (-31, -15), p < 0.001]. Subanalysis comparing both warm ischemia groups showed no significantly different effect of capsulotomy between groups. There was no methylene blue leakage after capsulotomy in any kidney. CONCLUSIONS: Renovascular perfusion can be improved with capsulotomy during HMP, without damaging the renal parenchyma. Follow-up studies need to determine which donor kidneys may benefit from capsulotomy.
